dbPTM

FRY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FRY_HUMAN
UniProt AC	Q5TBA9
Protein Name	Protein furry homolog
Gene Name	FRY
Organism	Homo sapiens (Human).
Sequence Length	3013
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle
Protein Description	Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation..
Protein Sequence	MASQQDSGFFEISIKYLLKSWSNTSPVGNGYIKPPVPPASGTHREKGPPTMLPINVDPDSKPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKELRHKEQNPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHIFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSKTLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNSELIANGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFIALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHNVDLQWLVEWNAVLVNSHYDVKSPSHVWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAKKTSTAGSGDNYVTLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQCVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPLDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLNLVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSSPEDEVKDREGDVTASHGLRGNGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWNALANNEKWSNNLRITLQFLISLCGVSSDTVLLPYIKKVAIYLCRNNTIQTMEELLFELQQTEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQENFPDAEENKILKESDERFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCWAPLVDYLPETITPRGPLHRCNIAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHSIASVLLQTREMGEAKTLTVQPAYQPEYLYTGGFDFLREDQSSPVPDSGLSSSSTSSSISLGGSSGNLPQMTQEVEDVDTAAETDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFKDSKSGFHLEHQLSEVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNSDLLTVLSRSSSPDLSSSSKLTASRKSTGQLNMNPGTTSGNTATAERSRHQRSFSVPKKFGVIDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNLLATIFWVTVALMESDFEFEYLMALRLLSRLLAHMPLDKAENREKLEKLQAQLKWADFSGLQQLLLKGFTSLTTTDLTLQLFSLLTPVSKISMVDASHAIGFPLNVLCLLPQLIQHFENPNQFCKDIAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADITLNMVTYLAELLEKGLPSVQQPLLQVIYSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSVHWREALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSTSSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDNFNWGVRRRSLDSLDKCDMQILEERQLSGSTPSLNKMHHEDSDESSEEEDLTASQILEHSDLIMTLSPSEETNPMELLTTACDSTPAEPHSFNTRMSSFDASLPDMNNLQISEGSKAEAVREEEDTTVHEDDLSSSINELPAAFECSDSFSLDMTEGEEKGNRALDQFTLASFGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSMPELLNMSRELSDLKKHLKEASAVIAADPLYSDGAWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTTFLPDSSVSGTSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	FFEISIKYLLKSWSN CCHHHHHHHHHHCCC	18.65	28270605
20	Phosphorylation	SIKYLLKSWSNTSPV HHHHHHHHCCCCCCC	35.39	28270605
22	Phosphorylation	KYLLKSWSNTSPVGN HHHHHHCCCCCCCCC	37.00	28270605
24	Phosphorylation	LLKSWSNTSPVGNGY HHHHCCCCCCCCCCC	28.97	28270605
25	Phosphorylation	LKSWSNTSPVGNGYI HHHCCCCCCCCCCCC	23.10	28270605
31	Phosphorylation	TSPVGNGYIKPPVPP CCCCCCCCCCCCCCC	15.12	28270605
50	Phosphorylation	HREKGPPTMLPINVD CCCCCCCCEEECCCC	34.18	20860994
92	Ubiquitination	IMAEPLEKPLTKSLQ EEECCCCCCCCHHHH	53.67	21906983
209	Phosphorylation	LAFKHFKYKEGYLGP HHHHHCCCCCCCCCC	17.21	21082442
213	Phosphorylation	HFKYKEGYLGPNTGN HCCCCCCCCCCCCCC	15.02	19690332
343	Phosphorylation	CLRNFVESLYDTTLE HHHHHHHHHHHHHHH	27.25	25072903
345	Phosphorylation	RNFVESLYDTTLELS HHHHHHHHHHHHHHH	22.11	25072903
347	Phosphorylation	FVESLYDTTLELSSR HHHHHHHHHHHHHCC	21.52	25072903
348	Phosphorylation	VESLYDTTLELSSRK HHHHHHHHHHHHCCC	18.48	25072903
352	Phosphorylation	YDTTLELSSRKKHSL HHHHHHHHCCCCHHH	20.79	25072903
353	Phosphorylation	DTTLELSSRKKHSLA HHHHHHHCCCCHHHH	61.82	25072903
406	Phosphorylation	MARVALESLYRLLWV HHHHHHHHHHHHHHH	31.39	24719451
442	Phosphorylation	TTLFPKGSRGVVPRD HHHCCCCCCCCCCCC	31.80	-
508	Phosphorylation	AFLVIADSLQQKDGE HHHHHHHHHHCCCCC	21.03	-
536	Phosphorylation	NTLRVKKTYLSKTLT CEEEEECEEECCCCC	24.79	25954137
539	Phosphorylation	RVKKTYLSKTLTEEE EEECEEECCCCCHHH	17.12	25954137
541	Phosphorylation	KKTYLSKTLTEEEAK ECEEECCCCCHHHHH	35.22	25954137
543	Phosphorylation	TYLSKTLTEEEAKMI EEECCCCCHHHHHHH	46.73	27174698
553	Phosphorylation	EAKMIGMSLYYSQVR HHHHHCHHHHHHHHH	14.17	27174698
555	Phosphorylation	KMIGMSLYYSQVRKA HHHCHHHHHHHHHHH	8.18	27174698
556	Phosphorylation	MIGMSLYYSQVRKAV HHCHHHHHHHHHHHH	9.64	27174698
557	Phosphorylation	IGMSLYYSQVRKAVD HCHHHHHHHHHHHHH	14.51	27174698
581	Phosphorylation	VGRCMMLTNVQMLNK HHHHHHHHCHHHHCC	18.56	-
595	Phosphorylation	KEPEDMITGERKPKI CCCHHHCCCCCCCCH	26.76	-
607	Phosphorylation	PKIDLFRTCVAAIPR CCHHHHHHHHHHHHH	12.19	30257219
723	Phosphorylation	SELIANGSSHRIQSE CHHHHCCCCCCCCCC	23.84	28450419
724	Phosphorylation	ELIANGSSHRIQSER HHHHCCCCCCCCCCC	20.41	28450419
902	Phosphorylation	SPINAKKTSTAGSGD CCCCCCCCCCCCCCC	30.51	-
903	Phosphorylation	PINAKKTSTAGSGDN CCCCCCCCCCCCCCC	25.74	-
904	Phosphorylation	INAKKTSTAGSGDNY CCCCCCCCCCCCCCH	40.02	-
929	Phosphorylation	CFGVAKPSIMSPGHL HHCCCCCCCCCCCCC	30.16	23312004
932	Phosphorylation	VAKPSIMSPGHLRAS CCCCCCCCCCCCCCC	26.51	23312004
939	Phosphorylation	SPGHLRASTPEIMAT CCCCCCCCCCCCEEE	37.75	28450419
940	Phosphorylation	PGHLRASTPEIMATT CCCCCCCCCCCEEEC	24.77	27732954
946	Phosphorylation	STPEIMATTPDGTVS CCCCCEEECCCCCEE	22.83	28450419
947	Phosphorylation	TPEIMATTPDGTVSY CCCCEEECCCCCEEC	15.16	28450419
951	Phosphorylation	MATTPDGTVSYDNKA EEECCCCCEECCCCC	17.41	17924679
954	Phosphorylation	TPDGTVSYDNKAIGT CCCCCEECCCCCCCC	21.14	17924679
961	Phosphorylation	YDNKAIGTPSVGVLL CCCCCCCCCCHHHHH	13.28	25159151
963	Phosphorylation	NKAIGTPSVGVLLKQ CCCCCCCCHHHHHHH	31.20	25159151
995	Phosphorylation	LGFGRTNSLVFRELV HCCCCCCHHHHHHHH	25.87	-
1058	Phosphorylation	NGALERDTLALGALF CCHHHHHHHHHHHHH	21.83	22210691
1068	Phosphorylation	LGALFLEYVDLTRML HHHHHHHHHHHHHHH	11.04	22210691
1229	Phosphorylation	WAIDRCYTGSYQLAS HHHHCCCCCCHHHCC	24.23	28985074
1232	Phosphorylation	DRCYTGSYQLASGCF HCCCCCCHHHCCCCH	14.64	28985074
1251	Phosphorylation	TVCGSRNYPFDIVTL HHHCCCCCCHHHHHH	12.26	-
1302	Phosphorylation	VAEQRPGSILYGTHG HHHHCCCCEEEECCC	16.47	-
1307	Phosphorylation	PGSILYGTHGPLPPL CCCEEEECCCCCCCH	15.31	-
1347	Phosphorylation	EVSQRFPTTHPNGRQ HHHHHCCCCCCCCCE	34.72	-
1379	Phosphorylation	SRLLLPGSSPSSPED CCEECCCCCCCCCCH	36.82	28450419
1380	Phosphorylation	RLLLPGSSPSSPEDE CEECCCCCCCCCCHH	34.41	28450419
1382	Phosphorylation	LLPGSSPSSPEDEVK ECCCCCCCCCCHHCC	61.55	28450419
1383	Phosphorylation	LPGSSPSSPEDEVKD CCCCCCCCCCHHCCC	35.38	28450419
1574	Phosphorylation	RAHTRLESRYSNSSG HHHHHHHHHCCCCCC	40.90	29449344
1576	Phosphorylation	HTRLESRYSNSSGGS HHHHHHHCCCCCCCC	22.83	28450419
1577	Phosphorylation	TRLESRYSNSSGGSY HHHHHHCCCCCCCCC	29.17	28450419
1579	Phosphorylation	LESRYSNSSGGSYDE HHHHCCCCCCCCCCC	25.15	28450419
1580	Phosphorylation	ESRYSNSSGGSYDED HHHCCCCCCCCCCCC	51.96	28450419
1583	Phosphorylation	YSNSSGGSYDEDKND CCCCCCCCCCCCCCC	32.70	28450419
1584	Phosphorylation	SNSSGGSYDEDKNDP CCCCCCCCCCCCCCC	26.99	27251275
1593	Phosphorylation	EDKNDPISPYTGWLL CCCCCCCCCCCCEEE	19.76	28450419
1595	Phosphorylation	KNDPISPYTGWLLTI CCCCCCCCCCEEEEE	15.87	28450419
1596	Phosphorylation	NDPISPYTGWLLTIT CCCCCCCCCEEEEEE	25.84	28450419
1678	Phosphorylation	VFLGLDHYRPEVFEH HHHCCCCCCHHHHHH	27.77	-
1746	Phosphorylation	DFLREDQSSPVPDSG CCCCCCCCCCCCCCC	49.26	24275569
1761	Phosphorylation	LSSSSTSSSISLGGS CCCCCCCCCEECCCC	31.60	24275569
1827	Phosphorylation	SKSAEQLTNFLRHVV CCCHHHHHHHHHHHH	24.50	28985074
1891	Phosphorylation	HALSDLLSRLVEVIG HHHHHHHHHHHHHHH	30.76	-
1929	Phosphorylation	LSDCLKNSDLLTVLS HHHHHHCCCHHHHHC	28.22	24117733
1933	Phosphorylation	LKNSDLLTVLSRSSS HHCCCHHHHHCCCCC	27.05	30108239
1936	Phosphorylation	SDLLTVLSRSSSPDL CCHHHHHCCCCCCCC	26.27	19664994
1938	Phosphorylation	LLTVLSRSSSPDLSS HHHHHCCCCCCCCCC	31.62	28450419
1939	Phosphorylation	LTVLSRSSSPDLSSS HHHHCCCCCCCCCCC	44.79	28450419
1940	Phosphorylation	TVLSRSSSPDLSSSS HHHCCCCCCCCCCCC	24.55	28450419
1944	Phosphorylation	RSSSPDLSSSSKLTA CCCCCCCCCCCCCCC	35.24	28450419
1945	Phosphorylation	SSSPDLSSSSKLTAS CCCCCCCCCCCCCCC	46.02	28450419
1946	Phosphorylation	SSPDLSSSSKLTASR CCCCCCCCCCCCCCC	28.28	28450419
1947	Phosphorylation	SPDLSSSSKLTASRK CCCCCCCCCCCCCCC	33.36	28450419
1952	Phosphorylation	SSSKLTASRKSTGQL CCCCCCCCCCCCCCC	34.70	26437602
1955	Phosphorylation	KLTASRKSTGQLNMN CCCCCCCCCCCCCCC	36.34	28450419
1956	Phosphorylation	LTASRKSTGQLNMNP CCCCCCCCCCCCCCC	31.79	26657352
1965	Phosphorylation	QLNMNPGTTSGNTAT CCCCCCCCCCCCCCC	21.03	27080861
1966	Phosphorylation	LNMNPGTTSGNTATA CCCCCCCCCCCCCCC	40.32	27080861
1967	Phosphorylation	NMNPGTTSGNTATAE CCCCCCCCCCCCCCH	29.86	27080861
1970	Phosphorylation	PGTTSGNTATAERSR CCCCCCCCCCCHHHC	28.98	27080861
1981	Phosphorylation	ERSRHQRSFSVPKKF HHHCHHCCCCCCCCC	18.46	28060719
1983	Phosphorylation	SRHQRSFSVPKKFGV HCHHCCCCCCCCCCC	38.46	23401153
2000	Phosphorylation	RSSDPPRSATLDRIQ CCCCCCCCCHHHHHH	31.23	28450419
2002	Phosphorylation	SDPPRSATLDRIQAC CCCCCCCHHHHHHHH	30.36	28450419
2225	Phosphorylation	DITLNMVTYLAELLE HCHHHHHHHHHHHHH	11.31	28302921
2226	Phosphorylation	ITLNMVTYLAELLEK CHHHHHHHHHHHHHC	7.78	28302921
2292	Phosphorylation	NILKLVVSRSASLVL HHHHHHHHCCCCCCC	17.03	24719451
2350	Phosphorylation	RYDELQNSSGRDGKP CHHHHHCCCCCCCCC	22.62	28450419
2351	Phosphorylation	YDELQNSSGRDGKPR HHHHHCCCCCCCCCC	45.45	28270605
2365	Phosphorylation	RAMAVTRSTSSTSSG CEEEEEECCCCCCCC	24.23	28450419
2366	Phosphorylation	AMAVTRSTSSTSSGS EEEEEECCCCCCCCC	24.33	28450419
2367	Phosphorylation	MAVTRSTSSTSSGSN EEEEECCCCCCCCCC	32.63	28450419
2368	Phosphorylation	AVTRSTSSTSSGSNS EEEECCCCCCCCCCC	32.18	28450419
2369	Phosphorylation	VTRSTSSTSSGSNSN EEECCCCCCCCCCCE	27.03	28450419
2370	Phosphorylation	TRSTSSTSSGSNSNV EECCCCCCCCCCCEE	34.35	28450419
2371	Phosphorylation	RSTSSTSSGSNSNVL ECCCCCCCCCCCEEE	46.45	28450419
2373	Phosphorylation	TSSTSSGSNSNVLVP CCCCCCCCCCEEEEE	38.75	28450419
2375	Phosphorylation	STSSGSNSNVLVPVS CCCCCCCCEEEEECC	29.97	28450419
2411	Phosphorylation	CGQEVGLSKNPSVIF HCCHHCCCCCCCCEE	25.18	28450419
2419	Phosphorylation	KNPSVIFSSCGDLDL CCCCCEEECCCCHHH	17.37	28060719
2420	Phosphorylation	NPSVIFSSCGDLDLL CCCCEEECCCCHHHH	16.03	28060719
2451	Phosphorylation	ENMDDTNSEQQFRVF HCCCCCCHHHHHHHE	38.58	27251275
2487	Phosphorylation	NWGVRRRSLDSLDKC CHHHHHCCHHHHCCC	34.42	25159151
2490	Phosphorylation	VRRRSLDSLDKCDMQ HHHCCHHHHCCCCHH	43.70	25159151
2505	Phosphorylation	ILEERQLSGSTPSLN HHHHHHCCCCCCCHH	23.51	26657352
2507	Phosphorylation	EERQLSGSTPSLNKM HHHHCCCCCCCHHHC	33.49	26657352
2508	Phosphorylation	ERQLSGSTPSLNKMH HHHCCCCCCCHHHCC	22.03	23403867
2510	Phosphorylation	QLSGSTPSLNKMHHE HCCCCCCCHHHCCCC	44.66	23403867
2574	Phosphorylation	HSFNTRMSSFDASLP CCCCCCCHHCCCCCC	25.27	24719451
2575	Phosphorylation	SFNTRMSSFDASLPD CCCCCCHHCCCCCCC	20.15	26657352
2579	Phosphorylation	RMSSFDASLPDMNNL CCHHCCCCCCCCCCC	42.13	28348404
2649	Phosphorylation	LDQFTLASFGEGDRG CHHHHHCCCCCCCCC	36.58	28857561
2658	Phosphorylation	GEGDRGVSPPPSPFF CCCCCCCCCCCCHHH	34.22	27732954
2662	Phosphorylation	RGVSPPPSPFFSAIL CCCCCCCCHHHHHHH	39.86	27732954
2666	Phosphorylation	PPPSPFFSAILAAFQ CCCCHHHHHHHHHHC	18.12	27732954
2709	Phosphorylation	YTFHVFSSLFKNIQK HHHHHHHHHHHHHHH	26.76	24719451
2793	Phosphorylation	YNNRKEATLSWLANC CCCCHHHHHHHHHHC	23.55	-
2795	Phosphorylation	NRKEATLSWLANCKA CCHHHHHHHHHHCCC	18.71	-
2803	Phosphorylation	WLANCKATFAGGSRD HHHHCCCEECCCCCC	10.26	23403867
2808	Phosphorylation	KATFAGGSRDGVITC CCEECCCCCCCEEEE	26.70	23403867
2929	Phosphorylation	RQIRECRSLWPNDIF HHHHHHHHHCCCCCC	46.58	-
3006	Phosphorylation	LTTFLPDSSVSGTSL EEEECCCCCCCCCCC	30.60	30108239
3007	Phosphorylation	TTFLPDSSVSGTSL- EEECCCCCCCCCCC-	27.90	30108239
3009	Phosphorylation	FLPDSSVSGTSL--- ECCCCCCCCCCC---	38.00	30108239
3011	Phosphorylation	PDSSVSGTSL----- CCCCCCCCCC-----	21.25	30108239
3012	Phosphorylation	DSSVSGTSL------ CCCCCCCCC------	35.29	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2508	T	Phosphorylation	Kinase	CDK1	P06493	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FRY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FRY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of FRY_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FRY_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1936, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-951 AND TYR-954, ANDMASS SPECTROMETRY.	17924679 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-213, AND MASSSPECTROMETRY.	19690332 [Abstract]