ELOC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELOC_MOUSE
• UniProt AC: P83940
• Protein Name: Elongin-C
• Gene Name: Eloc {ECO:0000312|MGI:MGI:1915173}
• Organism: Mus musculus (Mouse).
• Sequence Length: 112
• Subcellular Localization: Nucleus .
• Protein Description: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells. [PubMed: 27863225]
• Protein Sequence: MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	S-nitrosocysteine	EEKTYGGCEGPDAMY CCCCCCCCCCCCEEE	4.79	-
11	Glutathionylation	EEKTYGGCEGPDAMY CCCCCCCCCCCCEEE	4.79	24333276
11	S-nitrosylation	EEKTYGGCEGPDAMY CCCCCCCCCCCCEEE	4.79	20925432
32	Acetylation	DGHEFIVKREHALTS CCCEEEEECCEEECC	47.45	22826441
43	Ubiquitination	ALTSGTIKAMLSGPG EECCCCHHHHHCCCC	27.81	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELOC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELOC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELOC_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOCS1_MOUSE	Socs1	physical	15304214
ELOB_MOUSE	Tceb2	physical	23897481
CUL5_HUMAN	CUL5	physical	23897481
SOCS2_HUMAN	SOCS2	physical	23897481
ELOB_HUMAN	TCEB2	physical	26496610
SF3B2_HUMAN	SF3B2	physical	26496610
CHM2B_HUMAN	CHMP2B	physical	26496610
CC174_HUMAN	CCDC174	physical	26496610
RBM26_HUMAN	RBM26	physical	26496610
TM189_HUMAN	TMEM189	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.