| UniProt ID | SOCS1_MOUSE | |
|---|---|---|
| UniProt AC | O35716 | |
| Protein Name | Suppressor of cytokine signaling 1 | |
| Gene Name | Socs1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 212 | |
| Subcellular Localization | Nucleus . Cytoplasmic vesicle . Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. | |
| Protein Description | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).. | |
| Protein Sequence | MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of SOCS1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SOCS1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SOCS1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SOCS1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TRIM8_MOUSE | Trim8 | physical | 12163497 | |
| ELOB_MOUSE | Tceb2 | physical | 9869640 | |
| ELOC_MOUSE | Tceb1 | physical | 9869640 | |
| PCNT_MOUSE | Pcnt | physical | 20622265 | |
| SHC1_MOUSE | Shc1 | physical | 20622265 | |
| TIF1B_MOUSE | Trim28 | physical | 20622265 | |
| 5NTC_MOUSE | Nt5c2 | physical | 20622265 | |
| BCLF1_MOUSE | Bclaf1 | physical | 20622265 | |
| PCSK4_MOUSE | Pcsk4 | physical | 20622265 | |
| PHAG1_MOUSE | Pag1 | physical | 16920712 | |
| TIRAP_MOUSE | Tirap | physical | 19296467 | |
| ELOC_HUMAN | TCEB1 | physical | 19385048 | |
| ELOB_HUMAN | TCEB2 | physical | 19385048 | |
| TBG1_MOUSE | Tubg1 | physical | 15456882 | |
| PRS10_MOUSE | Psmc6 | physical | 15456882 | |
| HS71B_MOUSE | Hspa1b | physical | 15456882 | |
| CUL2_MOUSE | Cul2 | physical | 15456882 | |
| VAV_MOUSE | Vav1 | physical | 15456882 | |
| INSR_MOUSE | Insr | physical | 15169905 | |
| INGR1_MOUSE | Ifngr1 | physical | 19734231 | |
| KIT_MOUSE | Kit | physical | 10679268 | |
| CSF1R_MOUSE | Csf1r | physical | 10679268 | |
| FAK2_MOUSE | Ptk2b | physical | 10679268 | |
| JAK2_MOUSE | Jak2 | physical | 10679268 | |
| CUL5_HUMAN | CUL5 | physical | 15601820 | |
| RBX2_HUMAN | RNF7 | physical | 15601820 | |
| ELOB_HUMAN | TCEB2 | physical | 15601820 | |
| ELOC_HUMAN | TCEB1 | physical | 15601820 | |
| PIM2_MOUSE | Pim2 | physical | 11854514 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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