5NTC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5NTC_MOUSE
• UniProt AC: Q3V1L4
• Protein Name: Cytosolic purine 5'-nucleotidase
• Gene Name: Nt5c2
• Organism: Mus musculus (Mouse).
• Sequence Length: 560
• Subcellular Localization: Cytoplasm.
• Protein Description: May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity)..
• Protein Sequence: MTTSWSDRLQNAADVPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCDTGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTTSWSDRL ------CCCCHHHHH	29.54	26643407
3	Phosphorylation	-----MTTSWSDRLQ -----CCCCHHHHHH	27.22	26643407
4	Phosphorylation	----MTTSWSDRLQN ----CCCCHHHHHHH	18.54	26643407
6	Phosphorylation	--MTTSWSDRLQNAA --CCCCHHHHHHHHH	16.78	26643407
211	Acetylation	AVDWVHYKGSLKEKT HHHHHHHCCCCCCHH	27.44	22826441
254	Acetylation	LATNSDYKYTDKIMT EECCCCCCCCCCHHH	46.82	23954790
292	Acetylation	LILVDARKPLFFGEG EEEEECCCCCEECCC	48.03	22826441
417	Phosphorylation	SNERPDISSIQRRIK CCCCCCHHHHHHHHH	28.86	28973931
418	Phosphorylation	NERPDISSIQRRIKK CCCCCHHHHHHHHHH	24.07	29514104
457	Phosphorylation	FASQVMRYADLYAAS HHHHHHHHHHHHHHH	6.08	25293948
461	Phosphorylation	VMRYADLYAASFINL HHHHHHHHHHHHHHH	10.73	25293948
464	Phosphorylation	YADLYAASFINLLYY HHHHHHHHHHHHHHH	20.63	25293948
470	Phosphorylation	ASFINLLYYPFSYLF HHHHHHHHHHHHHHH	16.56	25293948
471	Phosphorylation	SFINLLYYPFSYLFR HHHHHHHHHHHHHHH	9.58	25293948
474	Phosphorylation	NLLYYPFSYLFRAAH HHHHHHHHHHHHHHH	19.20	25293948
475	Phosphorylation	LLYYPFSYLFRAAHV HHHHHHHHHHHHHHH	15.39	25293948
502	Phosphorylation	VDINEMESPLATRNR ECHHHCCCCCCCCCC	24.73	26060331
510	Phosphorylation	PLATRNRTSVDFKDT CCCCCCCCCCCCCCC	36.33	26824392
511	Phosphorylation	LATRNRTSVDFKDTD CCCCCCCCCCCCCCH	19.22	26824392
527	Phosphorylation	KRHQLTRSISEIKPP HHHCCHHCHHHCCCC	25.82	26239621
529	Phosphorylation	HQLTRSISEIKPPNL HCCHHCHHHCCCCCC	34.22	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5NTC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5NTC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5NTC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of 5NTC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-527, AND MASSSPECTROMETRY.
PubMed: 17242355