PIM2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIM2_MOUSE
• UniProt AC: Q62070
• Protein Name: Serine/threonine-protein kinase pim-2
• Gene Name: Pim2
• Organism: Mus musculus (Mouse).
• Sequence Length: 370
• Protein Description: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate..
• Protein Sequence: MARATNLNAAPSAGASGPPDSLPSTLAPPSPGSPAALPRASTPCGLSGFSGLNIRSTSSMLTKPLQGHPSPPVTPTQPPGGKDRAAFEAEYRLGPLLGKGGFGTVFAGHRVTDRRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLWKVGEGNGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKGPLGESCSRSFFTQVVAAVQHCHARGVVHRDIKDENILIDLCRGSIKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPCSRPSLEEILLDPWMQSPAEEKPINSSKGSPTPLPWSLLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 2)	Phosphorylation	-	34.38	27566939
8 (in isoform 2)	Phosphorylation	-	35.81	27566939
16 (in isoform 2)	Phosphorylation	-	51.41	27566939
33	Phosphorylation	LAPPSPGSPAALPRA CCCCCCCCCCCCCCC	18.10	25266776
41	Phosphorylation	PAALPRASTPCGLSG CCCCCCCCCCCCCCC	33.87	25266776
42	Phosphorylation	AALPRASTPCGLSGF CCCCCCCCCCCCCCC	22.93	27566939
47	Phosphorylation	ASTPCGLSGFSGLNI CCCCCCCCCCCCCCC	24.07	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIM2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIM2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIM2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOCS1_MOUSE	Socs1	physical	11854514

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.