dbPTM

TBG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBG1_MOUSE
UniProt AC	P83887
Protein Name	Tubulin gamma-1 chain
Gene Name	Tubg1
Organism	Mus musculus (Mouse).
Sequence Length	451
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Mainly localizes to the centrosome, but a fraction is found outside of the centrosome in the cytoplasm.
Protein Description	Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity)..
Protein Sequence	MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSSYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNLIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQFDKLRKREAFMEQFRKEDIFKDNFDEMDTSREIVQQLIDEYHAATRPDYISWGTQEQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	LCAEHGISPEGIVEE HHHHCCCCCCHHHHH	22.84	22067460
131	Phosphorylation	READGSDSLEGFVLC CCCCCCCCCCEEEEE	29.98	19648910
277	Phosphorylation	MTGYTPLTTDQSVAS CCCCCCCCCCCHHHH	29.54	29899451
284	Phosphorylation	TTDQSVASVRKTTVL CCCCHHHHCCHHHHH	21.94	26824392
364	Phosphorylation	QVALSRKSPYLPSAH HHHHHCCCCCCCCHH	20.05	22067460
410	Ubiquitination	AFMEQFRKEDIFKDN HHHHHHHHHHHHHCC	62.11	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
131	S	Phosphorylation	Kinase	BRSK1	Q5RJI5	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
131	S	Phosphorylation		19648910
Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBG1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AIFM1_HUMAN	AIFM1	physical	20360068
GCP6_HUMAN	TUBGCP6	physical	20360068
GCP2_HUMAN	TUBGCP2	physical	20360068
DYHC1_HUMAN	DYNC1H1	physical	20360068
GCP3_HUMAN	TUBGCP3	physical	20360068
GCP5_HUMAN	TUBGCP5	physical	20360068
MZT2B_HUMAN	MZT2B	physical	20360068
LG3BP_HUMAN	LGALS3BP	physical	20360068
MZT2A_HUMAN	MZT2A	physical	20360068
MZT1_HUMAN	MZT1	physical	20360068
DNJA1_HUMAN	DNAJA1	physical	20360068
GCP4_HUMAN	TUBGCP4	physical	20360068
NSUN2_HUMAN	NSUN2	physical	20360068
PRIC3_HUMAN	PRICKLE3	physical	20360068
TBG1_HUMAN	TUBG1	physical	20360068
ROCK2_MOUSE	Rock2	physical	17015463
AL1B1_HUMAN	ALDH1B1	physical	26496610
AL3A2_HUMAN	ALDH3A2	physical	26496610
ADT2_HUMAN	SLC25A5	physical	26496610
COPD_HUMAN	ARCN1	physical	26496610
AT1A1_HUMAN	ATP1A1	physical	26496610
C1QBP_HUMAN	C1QBP	physical	26496610
C4BPA_HUMAN	C4BPA	physical	26496610
FMNL1_HUMAN	FMNL1	physical	26496610
TCPZ_HUMAN	CCT6A	physical	26496610
COPA_HUMAN	COPA	physical	26496610
COPB_HUMAN	COPB1	physical	26496610
CPSM_HUMAN	CPS1	physical	26496610
FAS_HUMAN	FASN	physical	26496610
FOXM1_HUMAN	FOXM1	physical	26496610
FMR1_HUMAN	FMR1	physical	26496610
VKGC_HUMAN	GGCX	physical	26496610
DHE3_HUMAN	GLUD1	physical	26496610
LG3BP_HUMAN	LGALS3BP	physical	26496610
NCBP1_HUMAN	NCBP1	physical	26496610
NDUA4_HUMAN	NDUFA4	physical	26496610
NHS_HUMAN	NHS	physical	26496610
OXA1L_HUMAN	OXA1L	physical	26496610
PYC_HUMAN	PC	physical	26496610
PFKAM_HUMAN	PFKM	physical	26496610
PON2_HUMAN	PON2	physical	26496610
RANG_HUMAN	RANBP1	physical	26496610
RBBP6_HUMAN	RBBP6	physical	26496610
TXTP_HUMAN	SLC25A1	physical	26496610
SSRG_HUMAN	SSR3	physical	26496610
STXB2_HUMAN	STXBP2	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
VAV2_HUMAN	VAV2	physical	26496610
SF01_HUMAN	SF1	physical	26496610
FXR1_HUMAN	FXR1	physical	26496610
GEMI2_HUMAN	GEMIN2	physical	26496610
B4GT4_HUMAN	B4GALT4	physical	26496610
SUCA_HUMAN	SUCLG1	physical	26496610
RTL8C_HUMAN	FAM127A	physical	26496610
PMYT1_HUMAN	PKMYT1	physical	26496610
FXR2_HUMAN	FXR2	physical	26496610
BAG2_HUMAN	BAG2	physical	26496610
NPA1P_HUMAN	URB1	physical	26496610
UBP15_HUMAN	USP15	physical	26496610
PDCD6_HUMAN	PDCD6	physical	26496610
CMC2_HUMAN	SLC25A13	physical	26496610
DNJA2_HUMAN	DNAJA2	physical	26496610
TBB4B_HUMAN	TUBB4B	physical	26496610
GCP3_HUMAN	TUBGCP3	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
HOIL1_HUMAN	RBCK1	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
SRS10_HUMAN	SRSF10	physical	26496610
GCP2_HUMAN	TUBGCP2	physical	26496610
SRSF8_HUMAN	SRSF8	physical	26496610
AFG32_HUMAN	AFG3L2	physical	26496610
TEST_HUMAN	PRSS21	physical	26496610
GCN1_HUMAN	GCN1L1	physical	26496610
NCBP2_HUMAN	NCBP2	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
KIF1B_HUMAN	KIF1B	physical	26496610
ATX10_HUMAN	ATXN10	physical	26496610
PNKD_HUMAN	PNKD	physical	26496610
GCP4_HUMAN	TUBGCP4	physical	26496610
RBMX_HUMAN	RBMX	physical	26496610
NDK7_HUMAN	NME7	physical	26496610
CAB45_HUMAN	SDF4	physical	26496610
SRRT_HUMAN	SRRT	physical	26496610
ATD3A_HUMAN	ATAD3A	physical	26496610
NNRD_HUMAN	CARKD	physical	26496610
BDP1_HUMAN	BDP1	physical	26496610
TM165_HUMAN	TMEM165	physical	26496610
BBX_HUMAN	BBX	physical	26496610
ATG3_HUMAN	ATG3	physical	26496610
CSN7B_HUMAN	COPS7B	physical	26496610
ELOV1_HUMAN	ELOVL1	physical	26496610
SPA5L_HUMAN	SPATA5L1	physical	26496610
DYHC2_HUMAN	DYNC2H1	physical	26496610
IPO4_HUMAN	IPO4	physical	26496610
GHC1_HUMAN	SLC25A22	physical	26496610
MZT2B_HUMAN	MZT2B	physical	26496610
M3K21_HUMAN	KIAA1804	physical	26496610
TBB6_HUMAN	TUBB6	physical	26496610
GCP6_HUMAN	TUBGCP6	physical	26496610
JUPI2_HUMAN	HN1L	physical	26496610
TIM50_HUMAN	TIMM50	physical	26496610
GCP5_HUMAN	TUBGCP5	physical	26496610
PTPM1_HUMAN	PTPMT1	physical	26496610
NEDD1_HUMAN	NEDD1	physical	26496610
ZCH18_HUMAN	ZC3H18	physical	26496610
LAMA1_HUMAN	LAMA1	physical	26496610
MZT1_HUMAN	MZT1	physical	26496610
MZT2A_HUMAN	MZT2A	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TBG1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"SADB phosphorylation of gamma-tubulin regulates centrosomeduplication."; Alvarado-Kristensson M., Rodriguez M.J., Silio V., Valpuesta J.M.,Carrera A.C.; Nat. Cell Biol. 11:1081-1092(2009). Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-131, AND MUTAGENESIS OFSER-131.	19648910 [Abstract]

show