dbPTM

NHS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NHS_HUMAN
UniProt AC	Q6T4R5
Protein Name	Nance-Horan syndrome protein
Gene Name	NHS
Organism	Homo sapiens (Human).
Sequence Length	1651
Subcellular Localization	Isoform 1: Apical cell membrane Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, tight junction. Cell junction, focal adhesion. Colocalizes with the tight junction protein TJP1 in epithelial cells. Localizes to the leading
Protein Description	May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development..
Protein Sequence	MPFAKRIVEPQWLCRQRRPAPGPAVDASGGSAEPPPPLQPPGRRDLDEVEAPGPEEPARAVPAPSGLPPPPPPLPAPADQTQPPHGEASVAGEESTAGIPEAAPAAGEASSAAAAAAVLLMLDLCAVSNAALARVLRQLSDVARHACSLFQELESDIQLTHRRVWALQGKLGGVQRVLSTLDPKQEAVPVSNLDIESKLSVYYRAPWHQQRNIFLPATRPPCVEELHRHARQSLQALRREHRSRSDRREQRAAAPLSIAAPPLPAYPPAHSQRRREFKDRHFLTFNSTRSPSPTECCHMTPWSRKSHPPEDEDTDVMLGQRPKNPIHNIPSTLDKQTNWSKALPLPTPEEKMKQDAQVISSCIIPINVTGVGFDREASIRCSLVHSQSVLQRRRKLRRRKTISGIPRRVQQEIDSDESPVARERNVIVHTNPDPSNTVNRISGTRDSECQTEDILIAAPSRRRIRAQRGQSIAASLSHSAGNISALADKGDTMFTPAVSSRTRSRSLPREGNRGGDAEPKVGAKPSAYEEGESFVGDHERTPNDFSEAPSSPSAQDHQPTLGLACSQHLHSPQHKLSERGRSRLSRMAADSGSCDISSNSDTFGSPIHCISTAGVLLSSHMDQKDDHQSSSGNWSGSSSTCPSQTSETIPPAASPPLTGSSHCDSELSLNTAPHANEDASVFVTEQYNDHLDKVRGHRANSFTSTVADLLDDPNNSNTSDSEWNYLHHHHDASCRQDFSPERPKADSLGCPSFTSMATYDSFLEKSPSDKADTSSHFSVDTEGYYTSMHFDCGLKGNKSYVCHYAALGPENGQGVGASPGLPDCAWQDYLDHKRQGRPSISFRKPKAKPTPPKRSSSLRKSDGNADISEKKEPKISSGQHLPHSSREMKLPLDFANTPSRMENANLPTKQEPSWINQSEQGIKEPQLDASDIPPFKDEVAESTHYADLWLLNDLKTNDPYRSLSNSSTATGTTVIECIKSPESSESQTSQSESRATTPSLPSVDNEFKLASPEKLAGLASPSSGYSSQSETPTSSFPTAFFSGPLSPGGSKRKPKVPERKSSLQQPSLKDGTISLSKDLELPIIPPTHLDLSALHNVLNKPFHHRHPLHVFTHNKQNTVGETLRSNPPPSLAITPTILKSVNLRSINKSEEVKQKEENNTDLPYLEESTLTTAALSPSKIRPHTANKSVSRQYSTEDTILSFLDSSAVEMGPDKLHLEKNSTFDVKNRCDPETITSAGSSLLDSNVTKDQVRTETEPIPENTPTKNCAFPTEGFQRVSAARPNDLDGKIIQYGPGPDETLEQVQKAPSAGLEEVAQPESVDVITSQSDSPTRATDVSNQFKHQFVMSRHHDKVPGTISYESEITSVNSFPEKCSKQENIASGISAKSASDNSKAEETQGNVDEASLKESSPSDDSIISPLSEDSQAEAEGVFVSPNKPRTTEDLFAVIHRSKRKVLGRKDSGDMSVRSKSRAPLSSSSSSASSITSPSSNVTTPNSQRSPGLIYRNAKKSNTSNEEFKLLLLKKGSRSDSSYRMSATEILKSPILPKPPGELTAESPQSTDDAHQGSQGAEALSPLSPCSPRVNAEGFSSKSFATSASARVGRSRAPPAASSSRYSVRCRLYNTPMQAISEGETENSDGSPHDDRSSQSST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
115	Phosphorylation	EASSAAAAAAVLLML HHHHHHHHHHHHHHH	7.39	24719451
134	Phosphorylation	VSNAALARVLRQLSD HCHHHHHHHHHHHHH	28.93	32645325
140	Phosphorylation	ARVLRQLSDVARHAC HHHHHHHHHHHHHHH	23.00	-
154	Phosphorylation	CSLFQELESDIQLTH HHHHHHHHHHHHHHH	45.68	24719451
155	Phosphorylation	SLFQELESDIQLTHR HHHHHHHHHHHHHHH	53.27	32645325
202	Phosphorylation	IESKLSVYYRAPWHQ HHHCEEEEEECCHHH	5.48	-
203	Phosphorylation	ESKLSVYYRAPWHQQ HHCEEEEEECCHHHC	9.72	-
238	Phosphorylation	RQSLQALRREHRSRS HHHHHHHHHHHHHHH	44.98	24719451
241	Phosphorylation	LQALRREHRSRSDRR HHHHHHHHHHHHHHH	31.07	24719451
243	Phosphorylation	ALRREHRSRSDRREQ HHHHHHHHHHHHHHH	37.74	22817900
257	Phosphorylation	QRAAAPLSIAAPPLP HHHHCCCCCCCCCCC	14.77	-
271	Phosphorylation	PAYPPAHSQRRREFK CCCCCCCCHHHHHHC	27.73	28857561
281	Phosphorylation	RREFKDRHFLTFNST HHHHCCCCEEEECCC	32.00	32142685
290	Phosphorylation	LTFNSTRSPSPTECC EEECCCCCCCCCCCC	65.92	28857561
292	Phosphorylation	FNSTRSPSPTECCHM ECCCCCCCCCCCCCC	61.60	30576142
294	Phosphorylation	STRSPSPTECCHMTP CCCCCCCCCCCCCCC	35.83	30576142
302	Phosphorylation	ECCHMTPWSRKSHPP CCCCCCCCCCCCCCC	77.02	24719451
310	Phosphorylation	SRKSHPPEDEDTDVM CCCCCCCCCCCCCCC	37.49	-
311	Phosphorylation	RKSHPPEDEDTDVML CCCCCCCCCCCCCCC	33.35	32645325
329	Phosphorylation	PKNPIHNIPSTLDKQ CCCCCCCCCCCCCCC	60.70	24719451
331	Phosphorylation	NPIHNIPSTLDKQTN CCCCCCCCCCCCCCC	5.50	30266825
332	Phosphorylation	PIHNIPSTLDKQTNW CCCCCCCCCCCCCCH	56.97	30266825
337	Phosphorylation	PSTLDKQTNWSKALP CCCCCCCCCHHHCCC	4.99	29083192
340	Phosphorylation	LDKQTNWSKALPLPT CCCCCCHHHCCCCCC	9.75	29083192
347	Phosphorylation	SKALPLPTPEEKMKQ HHCCCCCCHHHHHHH	5.22	28674419
355	Phosphorylation	PEEKMKQDAQVISSC HHHHHHHHHHHHHHC	48.92	32142685
361	Phosphorylation	QDAQVISSCIIPINV HHHHHHHHCEEEEEE	24.47	27251275
367	Phosphorylation	SSCIIPINVTGVGFD HHCEEEEEEECCCCC	28.01	27251275
376	Phosphorylation	TGVGFDREASIRCSL ECCCCCHHHHHHHHH	39.12	32142685
380	Phosphorylation	FDREASIRCSLVHSQ CCHHHHHHHHHHCCH	20.68	18669648
382	Phosphorylation	REASIRCSLVHSQSV HHHHHHHHHHCCHHH	35.58	27251275
386	Phosphorylation	IRCSLVHSQSVLQRR HHHHHHCCHHHHHHH	49.86	28857561
388	Phosphorylation	CSLVHSQSVLQRRRK HHHHCCHHHHHHHHH	7.91	28387310
394	Phosphorylation	QSVLQRRRKLRRRKT HHHHHHHHHHHHCCC	49.27	18669648
397	Phosphorylation	LQRRRKLRRRKTISG HHHHHHHHHCCCCCC	29.66	18669648
401	Phosphorylation	RKLRRRKTISGIPRR HHHHHCCCCCCCCHH	43.57	23911959
403	Phosphorylation	LRRRKTISGIPRRVQ HHHCCCCCCCCHHHH	36.84	28060719
415	Phosphorylation	RVQQEIDSDESPVAR HHHHHHCCCCCCCCH	54.13	29255136
418	Phosphorylation	QEIDSDESPVARERN HHHCCCCCCCCHHCC	33.26	30266825
430	Phosphorylation	ERNVIVHTNPDPSNT HCCEEEECCCCCCCC	47.48	28555341
435	Phosphorylation	VHTNPDPSNTVNRIS EECCCCCCCCCCCCC	2.91	28555341
437	Phosphorylation	TNPDPSNTVNRISGT CCCCCCCCCCCCCCC	8.80	27050516
442	Phosphorylation	SNTVNRISGTRDSEC CCCCCCCCCCCCCCC	22.95	28555341
444	Phosphorylation	TVNRISGTRDSECQT CCCCCCCCCCCCCCC	23.90	28555341
451	Phosphorylation	TRDSECQTEDILIAA CCCCCCCCCCEEEEC	2.59	29449344
458	Phosphorylation	TEDILIAAPSRRRIR CCCEEEECCCHHHHH	34.20	32142685
460	Phosphorylation	DILIAAPSRRRIRAQ CEEEECCCHHHHHHH	34.71	29449344
471	Phosphorylation	IRAQRGQSIAASLSH HHHHHCCHHHHHHHC	23.89	22210691
475	Phosphorylation	RGQSIAASLSHSAGN HCCHHHHHHHCCCCC	21.28	30576142
477	Phosphorylation	QSIAASLSHSAGNIS CHHHHHHHCCCCCHH	5.86	22496350
479	Phosphorylation	IAASLSHSAGNISAL HHHHHHCCCCCHHHH	30.95	21082442
483	Phosphorylation	LSHSAGNISALADKG HHCCCCCHHHHHCCC	26.13	17081983
484	Phosphorylation	SHSAGNISALADKGD HCCCCCHHHHHCCCC	38.63	28387310
485	Phosphorylation	HSAGNISALADKGDT CCCCCHHHHHCCCCC	43.93	17081983
502	Phosphorylation	TPAVSSRTRSRSLPR CCCCCCCCCCCCCCC	24.47	28188228
504	Phosphorylation	AVSSRTRSRSLPREG CCCCCCCCCCCCCCC	24.53	28188228
506	Phosphorylation	SSRTRSRSLPREGNR CCCCCCCCCCCCCCC	25.04	20068231
528	Phosphorylation	VGAKPSAYEEGESFV CCCCCCHHHCCCCCC	31.15	27642862
530	Phosphorylation	AKPSAYEEGESFVGD CCCCHHHCCCCCCCC	23.09	27251275
532	Phosphorylation	PSAYEEGESFVGDHE CCHHHCCCCCCCCCC	40.27	32142685
533	Phosphorylation	SAYEEGESFVGDHER CHHHCCCCCCCCCCC	23.39	25159151
541	Phosphorylation	FVGDHERTPNDFSEA CCCCCCCCCCCCCCC	17.44	20873877
546	Phosphorylation	ERTPNDFSEAPSSPS CCCCCCCCCCCCCCC	42.94	29116813
550	Phosphorylation	NDFSEAPSSPSAQDH CCCCCCCCCCCCCCC	32.39	30576142
551	Phosphorylation	DFSEAPSSPSAQDHQ CCCCCCCCCCCCCCC	29.55	30576142
553	Phosphorylation	SEAPSSPSAQDHQPT CCCCCCCCCCCCCCC	36.09	29116813
560	Phosphorylation	SAQDHQPTLGLACSQ CCCCCCCCHHHHHHH	25.48	30576142
562	Phosphorylation	QDHQPTLGLACSQHL CCCCCCHHHHHHHHC	35.01	24719451
566	Phosphorylation	PTLGLACSQHLHSPQ CCHHHHHHHHCCCCC	3.03	30576142
571	Phosphorylation	ACSQHLHSPQHKLSE HHHHHCCCCCHHCHH	32.61	30576142
577	Phosphorylation	HSPQHKLSERGRSRL CCCCHHCHHHHHHHH	40.46	29449344
680	Phosphorylation	PHANEDASVFVTEQY CCCCCCCCEEEEEHH	28.99	19276368
684	Phosphorylation	EDASVFVTEQYNDHL CCCCEEEEEHHHHHH	19.36	18669648
701	Phosphorylation	VRGHRANSFTSTVAD HHCCHHCCHHHHHHH	44.74	22817900
703	Phosphorylation	GHRANSFTSTVADLL CCHHCCHHHHHHHHH	25.99	24144214
704	Phosphorylation	HRANSFTSTVADLLD CHHCCHHHHHHHHHC	14.42	24144214
705	Phosphorylation	RANSFTSTVADLLDD HHCCHHHHHHHHHCC	2.54	18669648
716	Phosphorylation	LLDDPNNSNTSDSEW HHCCCCCCCCCHHHH	27.00	24144214
718	Phosphorylation	DDPNNSNTSDSEWNY CCCCCCCCCHHHHHH	33.85	24144214
719	Phosphorylation	DPNNSNTSDSEWNYL CCCCCCCCHHHHHHH	41.43	24144214
721	Phosphorylation	NNSNTSDSEWNYLHH CCCCCCHHHHHHHHH	41.21	24144214
725	Phosphorylation	TSDSEWNYLHHHHDA CCHHHHHHHHHCCCH	50.99	18669648
733	Phosphorylation	LHHHHDASCRQDFSP HHHCCCHHHCCCCCC	23.17	24144214
739	Phosphorylation	ASCRQDFSPERPKAD HHHCCCCCCCCCCCC	28.67	23401153
759	Phosphorylation	SFTSMATYDSFLEKS CCCHHHCHHHHHHCC	37.53	25884760
784	Phosphorylation	FSVDTEGYYTSMHFD CCCCCCCEEEEEEEE	3.43	27642862
785	Phosphorylation	SVDTEGYYTSMHFDC CCCCCCEEEEEEEEC	13.09	27642862
786	Phosphorylation	VDTEGYYTSMHFDCG CCCCCEEEEEEEECC	10.02	27642862
799	Phosphorylation	CGLKGNKSYVCHYAA CCCCCCCCEEEEEEE	47.55	32142685
800	Phosphorylation	GLKGNKSYVCHYAAL CCCCCCCEEEEEEEE	3.52	22817900
804	Phosphorylation	NKSYVCHYAALGPEN CCCEEEEEEEECCCC	17.85	22817900
819	Phosphorylation	GQGVGASPGLPDCAW CCCCCCCCCCCCCCH	5.10	24719451
820	Phosphorylation	QGVGASPGLPDCAWQ CCCCCCCCCCCCCHH	24.28	32142685
829	Phosphorylation	PDCAWQDYLDHKRQG CCCCHHHHHHHHHCC	52.06	-
839	Phosphorylation	HKRQGRPSISFRKPK HHHCCCCCCCCCCCC	59.18	29449344
841	Phosphorylation	RQGRPSISFRKPKAK HCCCCCCCCCCCCCC	58.35	24719451
848	Phosphorylation	SFRKPKAKPTPPKRS CCCCCCCCCCCCCCC	69.36	32142685
850	Phosphorylation	RKPKAKPTPPKRSSS CCCCCCCCCCCCCCC	75.17	27251275
861	Phosphorylation	RSSSLRKSDGNADIS CCCCCCCCCCCCCCC	24.16	28985074
868	Phosphorylation	SDGNADISEKKEPKI CCCCCCCCCCCCCCC	42.05	-
869	Phosphorylation	DGNADISEKKEPKIS CCCCCCCCCCCCCCC	5.00	32142685
876	Phosphorylation	EKKEPKISSGQHLPH CCCCCCCCCCCCCCC	21.15	26074081
877	Phosphorylation	KKEPKISSGQHLPHS CCCCCCCCCCCCCCC	21.53	26074081
878	Phosphorylation	KEPKISSGQHLPHSS CCCCCCCCCCCCCCC	42.07	18669648
884	Phosphorylation	SGQHLPHSSREMKLP CCCCCCCCCCCCCCC	59.12	24719451
885	Phosphorylation	GQHLPHSSREMKLPL CCCCCCCCCCCCCCC	5.46	26074081
897	Phosphorylation	LPLDFANTPSRMENA CCCCCCCCHHHHHCC	27.65	21815630
899	Phosphorylation	LDFANTPSRMENANL CCCCCCHHHHHCCCC	65.25	18669648
960	Phosphorylation	DLKTNDPYRSLSNSS CCCCCCCCHHCCCCC	40.25	-
970	Phosphorylation	LSNSSTATGTTVIEC CCCCCCCCCCEEEEE	36.99	-
976	Phosphorylation	ATGTTVIECIKSPES CCCCEEEEEECCCCC	15.19	32142685
978	Phosphorylation	GTTVIECIKSPESSE CCEEEEEECCCCCCC	51.31	32142685
980	Phosphorylation	TVIECIKSPESSESQ EEEEEECCCCCCCCC	36.32	25159151
983	Phosphorylation	ECIKSPESSESQTSQ EEECCCCCCCCCCCC	53.96	30177828
984	Phosphorylation	CIKSPESSESQTSQS EECCCCCCCCCCCCC	55.22	30177828
986	Phosphorylation	KSPESSESQTSQSES CCCCCCCCCCCCCHH	11.16	30177828
988	Phosphorylation	PESSESQTSQSESRA CCCCCCCCCCCHHCC	7.47	30177828
989	Phosphorylation	ESSESQTSQSESRAT CCCCCCCCCCHHCCC	24.51	30177828
991	Phosphorylation	SESQTSQSESRATTP CCCCCCCCHHCCCCC	36.81	21955146
993	Phosphorylation	SQTSQSESRATTPSL CCCCCCHHCCCCCCC	47.20	21955146
996	Phosphorylation	SQSESRATTPSLPSV CCCHHCCCCCCCCCC	32.01	30266825
997	Phosphorylation	QSESRATTPSLPSVD CCHHCCCCCCCCCCC	3.38	29255136
999	Phosphorylation	ESRATTPSLPSVDNE HHCCCCCCCCCCCCC	30.29	30266825
1002	Phosphorylation	ATTPSLPSVDNEFKL CCCCCCCCCCCCCCC	45.17	29396449
1011	Phosphorylation	DNEFKLASPEKLAGL CCCCCCCCHHHHCCC	26.65	22617229
1020	Phosphorylation	EKLAGLASPSSGYSS HHHCCCCCCCCCCCC	8.39	28102081
1022	Phosphorylation	LAGLASPSSGYSSQS HCCCCCCCCCCCCCC	23.24	28102081
1023	Phosphorylation	AGLASPSSGYSSQSE CCCCCCCCCCCCCCC	28.59	28102081
1025	Phosphorylation	LASPSSGYSSQSETP CCCCCCCCCCCCCCC	25.32	32142685
1026	Phosphorylation	ASPSSGYSSQSETPT CCCCCCCCCCCCCCC	59.87	28102081
1027	Phosphorylation	SPSSGYSSQSETPTS CCCCCCCCCCCCCCC	50.02	28102081
1029	Phosphorylation	SSGYSSQSETPTSSF CCCCCCCCCCCCCCC	34.89	28102081
1031	Phosphorylation	GYSSQSETPTSSFPT CCCCCCCCCCCCCCC	63.31	28102081
1033	Phosphorylation	SSQSETPTSSFPTAF CCCCCCCCCCCCCCC	47.08	28102081
1034	Phosphorylation	SQSETPTSSFPTAFF CCCCCCCCCCCCCCC	73.74	28102081
1035	Phosphorylation	QSETPTSSFPTAFFS CCCCCCCCCCCCCCC	8.92	28102081
1038	Phosphorylation	TPTSSFPTAFFSGPL CCCCCCCCCCCCCCC	37.78	28102081
1042	Phosphorylation	SFPTAFFSGPLSPGG CCCCCCCCCCCCCCC	7.66	28102081
1046	Phosphorylation	AFFSGPLSPGGSKRK CCCCCCCCCCCCCCC	43.65	22210691
1050	Phosphorylation	GPLSPGGSKRKPKVP CCCCCCCCCCCCCCC	24.30	22210691
1061	Phosphorylation	PKVPERKSSLQQPSL CCCCCCCCCCCCCCC	17.06	24719451
1062	Phosphorylation	KVPERKSSLQQPSLK CCCCCCCCCCCCCCC	13.27	22777824
1074	Phosphorylation	SLKDGTISLSKDLEL CCCCCEEEECCCCCC	23.28	24719451
1118	Phosphorylation	FTHNKQNTVGETLRS EECCCCCCHHHHHHH	48.81	27251275
1122	Phosphorylation	KQNTVGETLRSNPPP CCCCHHHHHHHCCCC	4.21	27251275
1124	Phosphorylation	NTVGETLRSNPPPSL CCHHHHHHHCCCCCC	33.41	17081983
1128	Phosphorylation	ETLRSNPPPSLAITP HHHHHCCCCCCCCCH	34.20	17081983
1134	Phosphorylation	PPPSLAITPTILKSV CCCCCCCCHHHHHHC	62.37	25159151
1145	Phosphorylation	LKSVNLRSINKSEEV HHHCCHHCCCCCHHH	44.02	22817900
1147	Phosphorylation	SVNLRSINKSEEVKQ HCCHHCCCCCHHHHH	21.24	27251275
1149	Phosphorylation	NLRSINKSEEVKQKE CHHCCCCCHHHHHHH	5.80	22817900
1152	Phosphorylation	SINKSEEVKQKEENN CCCCCHHHHHHHHCC	10.94	24719451
1155	Phosphorylation	KSEEVKQKEENNTDL CCHHHHHHHHCCCCC	23.54	32142685
1160	Phosphorylation	KQKEENNTDLPYLEE HHHHHCCCCCCHHCH	22.23	28102081
1164	Phosphorylation	ENNTDLPYLEESTLT HCCCCCCHHCHHHCC	20.58	30266825
1168	Phosphorylation	DLPYLEESTLTTAAL CCCHHCHHHCCCCCC	6.12	30266825
1169	Phosphorylation	LPYLEESTLTTAALS CCHHCHHHCCCCCCC	22.28	30266825
1171	Phosphorylation	YLEESTLTTAALSPS HHCHHHCCCCCCCHH	29.08	30266825
1172	Phosphorylation	LEESTLTTAALSPSK HCHHHCCCCCCCHHH	19.22	30266825
1174	Phosphorylation	ESTLTTAALSPSKIR HHHCCCCCCCHHHCC	32.71	27251275
1176	Phosphorylation	TLTTAALSPSKIRPH HCCCCCCCHHHCCCC	38.85	30266825
1178	Phosphorylation	TTAALSPSKIRPHTA CCCCCCHHHCCCCCC	4.73	30266825
1190	Phosphorylation	HTANKSVSRQYSTED CCCCCCCCCCCCCHH	17.47	-
1193	Phosphorylation	NKSVSRQYSTEDTIL CCCCCCCCCCHHHHH	40.72	26657352
1194	Phosphorylation	KSVSRQYSTEDTILS CCCCCCCCCHHHHHH	7.90	22817900
1195	Phosphorylation	SVSRQYSTEDTILSF CCCCCCCCHHHHHHH	37.37	22817900
1198	Phosphorylation	RQYSTEDTILSFLDS CCCCCHHHHHHHHCH	63.66	28102081
1201	Phosphorylation	STEDTILSFLDSSAV CCHHHHHHHHCHHHH	32.99	-
1233	Phosphorylation	KNRCDPETITSAGSS CCCCCHHHHHHCCHH	40.38	30576142
1241	Phosphorylation	ITSAGSSLLDSNVTK HHHCCHHHHHCCCCH	30.58	18669648
1247	Phosphorylation	SLLDSNVTKDQVRTE HHHHCCCCHHHCCCC	23.89	30576142
1255	Phosphorylation	KDQVRTETEPIPENT HHHCCCCCCCCCCCC	23.30	29396449
1262	Phosphorylation	TEPIPENTPTKNCAF CCCCCCCCCCCCCCC	57.85	25159151
1264	Phosphorylation	PIPENTPTKNCAFPT CCCCCCCCCCCCCCC	13.70	25159151
1292	Phosphorylation	LDGKIIQYGPGPDET CCCCEEEECCCCHHH	48.47	23403867
1306	Phosphorylation	TLEQVQKAPSAGLEE HHHHHHHCCCCCHHH	39.56	27251275
1308	Phosphorylation	EQVQKAPSAGLEEVA HHHHHCCCCCHHHHH	33.16	18669648
1319	Phosphorylation	EEVAQPESVDVITSQ HHHHCCCCEEEEECC	9.98	29514088
1324	Phosphorylation	PESVDVITSQSDSPT CCCEEEEECCCCCCC	2.47	21955146
1325	Phosphorylation	ESVDVITSQSDSPTR CCEEEEECCCCCCCC	2.84	21955146
1327	Phosphorylation	VDVITSQSDSPTRAT EEEEECCCCCCCCCC	17.05	26657352
1329	Phosphorylation	VITSQSDSPTRATDV EEECCCCCCCCCCCC	35.16	25159151
1331	Phosphorylation	TSQSDSPTRATDVSN ECCCCCCCCCCCCCH	46.07	28387310
1334	Phosphorylation	SDSPTRATDVSNQFK CCCCCCCCCCCHHHH	38.37	29514088
1337	Phosphorylation	PTRATDVSNQFKHQF CCCCCCCCHHHHHHH	23.76	29514088
1381	Phosphorylation	SKQENIASGISAKSA CCCCCCCCCCCCCCC	50.14	28674151
1384	Phosphorylation	ENIASGISAKSASDN CCCCCCCCCCCCCCC	37.62	27251275
1387	Phosphorylation	ASGISAKSASDNSKA CCCCCCCCCCCCHHH	62.84	28674151
1389	Phosphorylation	GISAKSASDNSKAEE CCCCCCCCCCHHHHH	29.52	28674151
1392	Phosphorylation	AKSASDNSKAEETQG CCCCCCCHHHHHHCC	57.99	28674151
1405	Phosphorylation	QGNVDEASLKESSPS CCCCCHHHHCCCCCC	23.17	27251275
1409	Phosphorylation	DEASLKESSPSDDSI CHHHHCCCCCCCCCC	25.80	27251275
1410	Phosphorylation	EASLKESSPSDDSII HHHHCCCCCCCCCCC	3.01	27251275
1412	Phosphorylation	SLKESSPSDDSIISP HHCCCCCCCCCCCCC	9.63	27251275
1415	Phosphorylation	ESSPSDDSIISPLSE CCCCCCCCCCCCCCC	60.50	27251275
1418	Phosphorylation	PSDDSIISPLSEDSQ CCCCCCCCCCCCCCC	56.75	27251275
1421	Phosphorylation	DSIISPLSEDSQAEA CCCCCCCCCCCCHHH	52.70	27251275
1424	Phosphorylation	ISPLSEDSQAEAEGV CCCCCCCCCHHHCCE	8.69	27251275
1434	Phosphorylation	EAEGVFVSPNKPRTT HHCCEECCCCCCCCH	8.77	30576142
1438	Phosphorylation	VFVSPNKPRTTEDLF EECCCCCCCCHHHHH	55.22	24719451
1439	Phosphorylation	FVSPNKPRTTEDLFA ECCCCCCCCHHHHHH	57.39	24719451
1440	Phosphorylation	VSPNKPRTTEDLFAV CCCCCCCCHHHHHHH	39.46	27251275
1461	Phosphorylation	KVLGRKDSGDMSVRS CCCCCCCCCCCCCCC	24.99	30576142
1465	Phosphorylation	RKDSGDMSVRSKSRA CCCCCCCCCCCCCCC	22.55	28102081
1478	Phosphorylation	RAPLSSSSSSASSIT CCCCCCCCCCCCCCC	18.71	18669648
1482	Phosphorylation	SSSSSSASSITSPSS CCCCCCCCCCCCCCC	3.63	28985074
1485	Phosphorylation	SSSASSITSPSSNVT CCCCCCCCCCCCCCC	38.86	25627689
1486	Phosphorylation	SSASSITSPSSNVTT CCCCCCCCCCCCCCC	16.20	25159151
1488	Phosphorylation	ASSITSPSSNVTTPN CCCCCCCCCCCCCCC	46.67	-
1493	Phosphorylation	SPSSNVTTPNSQRSP CCCCCCCCCCCCCCC	51.26	28985074
1496	Phosphorylation	SNVTTPNSQRSPGLI CCCCCCCCCCCCCCE	5.72	28985074
1499	Phosphorylation	TTPNSQRSPGLIYRN CCCCCCCCCCCEECC	5.62	16964243
1509	Acetylation	LIYRNAKKSNTSNEE CEECCCCCCCCCCHH	30.43	26210075
1518	Acetylation	NTSNEEFKLLLLKKG CCCCHHHHEEEECCC	5.22	26210075
1523	Acetylation	EFKLLLLKKGSRSDS HHHEEEECCCCCCCC	15.42	26210075
1523	Methylation	EFKLLLLKKGSRSDS HHHEEEECCCCCCCC	15.42	115973971
1524	Methylation	FKLLLLKKGSRSDSS HHEEEECCCCCCCCC	5.18	115973979
1526	Phosphorylation	LLLLKKGSRSDSSYR EEEECCCCCCCCCCC	61.47	-
1528	Phosphorylation	LLKKGSRSDSSYRMS EECCCCCCCCCCCCC	55.83	-
1530	Phosphorylation	KKGSRSDSSYRMSAT CCCCCCCCCCCCCHH	49.04	-
1531	Phosphorylation	KGSRSDSSYRMSATE CCCCCCCCCCCCHHH	7.34	-
1532	Phosphorylation	GSRSDSSYRMSATEI CCCCCCCCCCCHHHH	24.87	22817900
1591	Methylation	NAEGFSSKSFATSAS CCCCCCCHHHHHHHH	17.70	115973987
1615	Phosphorylation	PAASSSRYSVRCRLY CCCCCCCEEEEEEEE	53.47	24719451
1616	Phosphorylation	AASSSRYSVRCRLYN CCCCCCEEEEEEEEC	36.80	24719451
1622	Phosphorylation	YSVRCRLYNTPMQAI EEEEEEEECCCCCHH	57.30	27642862
1624	Phosphorylation	VRCRLYNTPMQAISE EEEEEECCCCCHHHC	44.24	22210691
1630	Phosphorylation	NTPMQAISEGETENS CCCCCHHHCCCCCCC	48.12	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
401	T	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NHS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NHS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RPN1_HUMAN	RPN1	physical	10588643

Drug and Disease Associations

Kegg Disease
H01202	Cataract
H01292	Nance-Horan syndrome
OMIM Disease
302350	Nance-Horan syndrome (NHS)
302200	Cataract 40 (CTRCT40)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NHS_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-380; SER-394; SER-397;SER-1155; THR-1241 AND SER-1478, AND MASS SPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1478, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1124 AND SER-1128, ANDMASS SPECTROMETRY.	17081983 [Abstract]