B4GT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B4GT4_HUMAN
• UniProt AC: O60513
• Protein Name: Beta-1,4-galactosyltransferase 4
• Gene Name: B4GALT4
• Organism: Homo sapiens (Human).
• Sequence Length: 344
• Subcellular Localization: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Trans cisternae of Golgi stack.
• Protein Description: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids..
• Protein Sequence: MGFNLTFHLSYKFRLLLLLTLCLTVVGWATSNYFVGAIQEIPKAKEFMANFHKTLILGKGKTLTNEASTKKVELDNCPSVSPYLRGQSKLIFKPDLTLEEVQAENPKVSRGRYRPQECKALQRVAILVPHRNREKHLMYLLEHLHPFLQRQQLDYGIYVIHQAEGKKFNRAKLLNVGYLEALKEENWDCFIFHDVDLVPENDFNLYKCEEHPKHLVVGRNSTGYRLRYSGYFGGVTALSREQFFKVNGFSNNYWGWGGEDDDLRLRVELQRMKISRPLPEVGKYTMVFHTRDKGNEVNAERMKLLHQVSRVWRTDGLSSCSYKLVSVEHNPLYINITVDFWFGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	O-linked_Glycosylation	TLTNEASTKKVELDN CCCCCCCCCEEECCC	41.76	OGP
88	Phosphorylation	SPYLRGQSKLIFKPD CHHHCCCCEEEECCC	32.05	-
155	Phosphorylation	LQRQQLDYGIYVIHQ HHHHCCCCEEEEEEE	17.64	-
158	Phosphorylation	QQLDYGIYVIHQAEG HCCCCEEEEEEECCC	6.76	-
178	Phosphorylation	AKLLNVGYLEALKEE HHHCCHHHHHHHHHH	9.33	-
220	N-linked_Glycosylation	KHLVVGRNSTGYRLR CEEEECCCCCCCEEE	37.69	UniProtKB CARBOHYD
229	O-linked_Glycosylation	TGYRLRYSGYFGGVT CCCEEEECEEECCEE	22.15	OGP
314	Phosphorylation	QVSRVWRTDGLSSCS HHHHHHCCCCCCCCE	20.78	25072903
318	Phosphorylation	VWRTDGLSSCSYKLV HHCCCCCCCCEEEEE	34.52	25072903
319	Phosphorylation	WRTDGLSSCSYKLVS HCCCCCCCCEEEEEE	16.48	25072903
321	Phosphorylation	TDGLSSCSYKLVSVE CCCCCCCEEEEEECC	27.53	25072903
322	Phosphorylation	DGLSSCSYKLVSVEH CCCCCCEEEEEECCC	16.81	25072903
335	N-linked_Glycosylation	EHNPLYINITVDFWF CCCCEEEEEEEEEEC	15.43	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B4GT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B4GT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B4GT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NGLY1_HUMAN	NGLY1	physical	26186194
ITA6_HUMAN	ITGA6	physical	26186194
SP3_HUMAN	SP3	physical	26186194
ITA6_HUMAN	ITGA6	physical	28514442
NGLY1_HUMAN	NGLY1	physical	28514442
STRN3_HUMAN	STRN3	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
SDF2L_HUMAN	SDF2L1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.