| UniProt ID | PNKD_HUMAN | |
|---|---|---|
| UniProt AC | Q8N490 | |
| Protein Name | Probable hydrolase PNKD | |
| Gene Name | PNKD | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 385 | |
| Subcellular Localization |
Isoform 1: Membrane Peripheral membrane protein. Isoform 2: Cytoplasm. Nucleus. Isoform 3: Mitochondrion. |
|
| Protein Description | Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.. | |
| Protein Sequence | MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDPSDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKGTCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MAAVVAATALKGRGA CHHHHHHHHHCCCCH | 23.84 | 24702127 | |
| 11 | Ubiquitination | VVAATALKGRGARNA HHHHHHHCCCCHHHH | 44.06 | - | |
| 14 (in isoform 4) | Phosphorylation | - | 37.24 | 26552605 | |
| 16 (in isoform 4) | Phosphorylation | - | 39.92 | 26552605 | |
| 18 (in isoform 4) | Phosphorylation | - | 9.45 | 26552605 | |
| 20 (in isoform 4) | Phosphorylation | - | 3.87 | 26552605 | |
| 21 (in isoform 4) | Phosphorylation | - | 3.28 | 26552605 | |
| 23 (in isoform 4) | Phosphorylation | - | 18.33 | 26552605 | |
| 24 (in isoform 4) | Phosphorylation | - | 1.60 | 26552605 | |
| 46 | Phosphorylation | RALQSHSSPEGKEEP HHHHCCCCCCCCCCC | 22.88 | - | |
| 57 | Phosphorylation | KEEPEPLSPELEYIP CCCCCCCCHHHHHCC | 27.35 | 30266825 | |
| 59 (in isoform 3) | Phosphorylation | - | 51.35 | - | |
| 62 | Phosphorylation | PLSPELEYIPRKRGK CCCHHHHHCCCCCCC | 28.93 | 28122231 | |
| 110 | Ubiquitination | RYPKGHSKTQPRLFN HCCCCCCCCCCCCCC | 45.57 | - | |
| 114 (in isoform 2) | Phosphorylation | - | 41.93 | - | |
| 119 (in isoform 2) | Phosphorylation | - | 3.98 | 25884760 | |
| 121 | Phosphorylation | RLFNGVKVLPIPVLS CCCCCEEEEEECEEC | 7.74 | 17525332 | |
| 121 (in isoform 2) | Phosphorylation | - | 7.74 | 17525332 | |
| 127 (in isoform 2) | Phosphorylation | - | 4.46 | 28450419 | |
| 128 (in isoform 2) | Phosphorylation | - | 24.84 | 28450419 | |
| 130 (in isoform 2) | Phosphorylation | - | 25.03 | 28450419 | |
| 133 (in isoform 2) | Phosphorylation | - | 7.49 | 21406692 | |
| 138 (in isoform 2) | Phosphorylation | - | 18.52 | 21406692 | |
| 142 (in isoform 2) | Phosphorylation | - | 4.67 | 21406692 | |
| 203 | Phosphorylation | SPQDGIPYLTHPLCH CCCCCCCCCCCCCCC | 23.47 | - | |
| 205 | Phosphorylation | QDGIPYLTHPLCHQD CCCCCCCCCCCCCCC | 18.66 | - | |
| 226 | Phosphorylation | LQIRALATPGHTQGH EEEEEEECCCCCCCE | 30.56 | - | |
| 230 | Phosphorylation | ALATPGHTQGHLVYL EEECCCCCCCEEEEE | 42.01 | - | |
| 244 | Ubiquitination | LLDGEPYKGPSCLFS EECCCCCCCCCCCCC | 75.06 | - | |
| 328 | Phosphorylation | QRLERKGTCPSTLGE HHHHHHCCCCHHCCC | 25.03 | 28857561 | |
| 345 | Phosphorylation | SYNPFLRTHCLALQE HCCHHHHHHHHHHHH | 21.06 | 24719451 | |
| 361 | Phosphorylation | LGPGPGPTGDDDYSR HCCCCCCCCCCHHHH | 60.19 | 24719451 | |
| 366 | Phosphorylation | GPTGDDDYSRAQLLE CCCCCCHHHHHHHHH | 13.67 | 24719451 | |
| 384 | Phosphorylation | RLKDMHKSK------ HHHHHHHCC------ | 28.99 | 29083192 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PNKD_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PNKD_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PNKD_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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