DCNL5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCNL5_HUMAN
• UniProt AC: Q9BTE7
• Protein Name: DCN1-like protein 5
• Gene Name: DCUN1D5
• Organism: Homo sapiens (Human).
• Sequence Length: 237
• Protein Sequence: MPVKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEHFSSKKCLAWFYEYAGPDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEKLQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MPVKKKRKSPGVAAA CCCCCCCCCCCHHHH	70.63	-
9	Phosphorylation	PVKKKRKSPGVAAAV CCCCCCCCCCHHHHH	30.80	19664994
23	Methylation	VAEDGGLKKCKISSY HHCCCCCCCCEEHHH	60.44	-
23	Ubiquitination	VAEDGGLKKCKISSY HHCCCCCCCCEEHHH	60.44	21890473
23	Sumoylation	VAEDGGLKKCKISSY HHCCCCCCCCEEHHH	60.44	-
24	Methylation	AEDGGLKKCKISSYC HCCCCCCCCEEHHHH	45.89	-
24	Ubiquitination	AEDGGLKKCKISSYC HCCCCCCCCEEHHHH	45.89	-
26	Ubiquitination	DGGLKKCKISSYCRS CCCCCCCEEHHHHHC	55.28	-
26	Acetylation	DGGLKKCKISSYCRS CCCCCCCEEHHHHHC	55.28	25953088
41	Phosphorylation	QPPARLISGEEHFSS CCCCEECCCCCCCCC	44.75	25159151
47	Phosphorylation	ISGEEHFSSKKCLAW CCCCCCCCCHHHHHH	43.06	25850435
48	Phosphorylation	SGEEHFSSKKCLAWF CCCCCCCCHHHHHHH	34.88	25850435
49	Acetylation	GEEHFSSKKCLAWFY CCCCCCCHHHHHHHH	46.43	25953088
49	Ubiquitination	GEEHFSSKKCLAWFY CCCCCCCHHHHHHHH	46.43	-
50	Ubiquitination	EEHFSSKKCLAWFYE CCCCCCHHHHHHHHH	36.11	-
98	Sulfoxidation	WKLEAESMGFFTKEE HHHHHHHCCCCCHHH	4.00	21406390
103	Ubiquitination	ESMGFFTKEEWLKGM HHCCCCCHHHHHHCC	48.78	-
108	Ubiquitination	FTKEEWLKGMTSLQC CCHHHHHHCCCCCCC	47.94	-
120	Ubiquitination	LQCDCTEKLQNKFDF CCCCCCHHHHHHHHH	36.90	-
124	Ubiquitination	CTEKLQNKFDFLRSQ CCHHHHHHHHHHHHH	33.09	-
124	Acetylation	CTEKLQNKFDFLRSQ CCHHHHHHHHHHHHH	33.09	25953088
139	Ubiquitination	LNDISSFKNIYRYAF HHCHHHHHHHHHHHH	44.37	21890473
163	Ubiquitination	SLDIDTAKSMLALLL CCCHHHHHHHHHHHH	38.19	-
164	Phosphorylation	LDIDTAKSMLALLLG CCHHHHHHHHHHHHH	19.30	23403867
194	Ubiquitination	SKYRVMNKDQWYNVL HCCCCCCHHHHHHHH	32.95	21890473
198	Phosphorylation	VMNKDQWYNVLEFSR CCCHHHHHHHHHHEE	6.97	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCNL5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
41	S	Neddylation	Phosphorylation at Ser-41 is independent of cullin's interaction and neddylation.	23186163
41	S	Phosphorylation	Phosphorylation at Ser-41 is independent of cullin's interaction and neddylation.	23186163

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCNL5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	23201271
CUL2_HUMAN	CUL2	physical	23201271
CUL3_HUMAN	CUL3	physical	23201271
CUL4A_HUMAN	CUL4A	physical	23201271
CUL4B_HUMAN	CUL4B	physical	23201271
CUL5_HUMAN	CUL5	physical	23201271
ZN363_HUMAN	RCHY1	physical	21988832
CAND1_HUMAN	CAND1	physical	24192928
CUL1_HUMAN	CUL1	physical	24192928
CUL2_HUMAN	CUL2	physical	24192928
CUL3_HUMAN	CUL3	physical	24192928
RBX1_HUMAN	RBX1	physical	24192928
UBC12_HUMAN	UBE2M	physical	24192928
LNX1_HUMAN	LNX1	physical	25416956
UBC12_HUMAN	UBE2M	physical	23201271
UBE2F_HUMAN	UBE2F	physical	23201271
TLN2_HUMAN	TLN2	physical	26344197
UBL7_HUMAN	UBL7	physical	26344197
CUL1_HUMAN	CUL1	physical	26906416
CUL2_HUMAN	CUL2	physical	26906416
CUL3_HUMAN	CUL3	physical	26906416
CUL5_HUMAN	CUL5	physical	26906416
CAND1_HUMAN	CAND1	physical	26906416
RBX1_HUMAN	RBX1	physical	26906416
RBX2_HUMAN	RNF7	physical	26906416
CUL4A_HUMAN	CUL4A	physical	26906416
CUL4B_HUMAN	CUL4B	physical	26906416
DDB1_HUMAN	DDB1	physical	26906416
ACADV_HUMAN	ACADVL	physical	26906416
UBC12_HUMAN	UBE2M	physical	26906416

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND MASSSPECTROMETRY.
PubMed: 18669648