AR2BP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AR2BP_HUMAN
• UniProt AC: Q9Y2Y0
• Protein Name: ADP-ribosylation factor-like protein 2-binding protein
• Gene Name: ARL2BP
• Organism: Homo sapiens (Human).
• Sequence Length: 163
• Subcellular Localization: Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. The complex formed with ARL2BP, ARL2 and SLC25A4
• Protein Description: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2..
• Protein Sequence: MDALEGESFALSFSSASDAEFDAVVGYLEDIIMDDEFQLLQRNFMDKYYLEFEDTEENKLIYTPIFNEYISLVEKYIEEQLLQRIPEFNMAAFTTTLQHHKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEGRGLDLSSGLVVTSLCKSSSLPASQNNLRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	QRNFMDKYYLEFEDT HHHHHHHCCEEEECC	14.71	26074081
49	Phosphorylation	RNFMDKYYLEFEDTE HHHHHHCCEEEECCC	12.90	26074081
55	Phosphorylation	YYLEFEDTEENKLIY CCEEEECCCCCEEEE	37.69	26074081
62	Phosphorylation	TEENKLIYTPIFNEY CCCCEEEEEHHHHHH	19.52	26074081
63	Phosphorylation	EENKLIYTPIFNEYI CCCEEEEEHHHHHHH	11.69	26074081
69	Phosphorylation	YTPIFNEYISLVEKY EEHHHHHHHHHHHHH	9.27	29523821
71	Phosphorylation	PIFNEYISLVEKYIE HHHHHHHHHHHHHHH	26.01	29523821
128	Phosphorylation	FKEMFLDYRAEKEGR HHHHHHHHHHHHCCC	17.55	-
140	Phosphorylation	EGRGLDLSSGLVVTS CCCCCCCCCCEEEEH	23.25	29743597
141	Phosphorylation	GRGLDLSSGLVVTSL CCCCCCCCCEEEEHH	43.36	22199227
150	Ubiquitination	LVVTSLCKSSSLPAS EEEEHHHHHCCCCCH	59.68	-
151	Phosphorylation	VVTSLCKSSSLPASQ EEEHHHHHCCCCCHH	24.94	29978859
152	Phosphorylation	VTSLCKSSSLPASQN EEHHHHHCCCCCHHC	22.76	29978859
153	Phosphorylation	TSLCKSSSLPASQNN EHHHHHCCCCCHHCC	45.52	25159151
157	Phosphorylation	KSSSLPASQNNLRH- HHCCCCCHHCCCCC-	31.34	17525332
162	Methylation	PASQNNLRH------ CCHHCCCCC------	35.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AR2BP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AR2BP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AR2BP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADT1_MOUSE	Slc25a4	physical	11809823
KCC2D_HUMAN	CAMK2D	physical	21988832
MPP3_HUMAN	MPP3	physical	21988832
ARL2_HUMAN	ARL2	physical	10488091
ARL3_HUMAN	ARL3	physical	27173435
CFA20_HUMAN	CFAP20	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615434: Retinitis pigmentosa with or without situs inversus (RPSI)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, AND MASSSPECTROMETRY.
PubMed: 17525332