dbPTM

FOXM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FOXM1_HUMAN
UniProt AC	Q08050
Protein Name	Forkhead box protein M1
Gene Name	FOXM1
Organism	Homo sapiens (Human).
Sequence Length	763
Subcellular Localization	Nucleus.
Protein Description	Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response..
Protein Sequence	MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQAEASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALCEQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKVEEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMSSELARHSKRVRIAPKVLLAEEGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEMPHLARPIKVESPPLEEWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVSEMLVIQHRERRERSRSRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPASQLSYSQEVGGPFKTPIKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQGASDPLPDPLGLMDLSTTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MKTSPRRPLI -----CCCCCCCCCC	42.54	28102081
4	Phosphorylation	----MKTSPRRPLIL ----CCCCCCCCCCC	15.76	22094256
25	Phosphorylation	LPVQNAPSETSEEEP CCCCCCCCCCCCCCC	51.61	28634298
27	Phosphorylation	VQNAPSETSEEEPKR CCCCCCCCCCCCCCC	45.86	28634298
28	Phosphorylation	QNAPSETSEEEPKRS CCCCCCCCCCCCCCC	38.67	28634298
35	Phosphorylation	SEEEPKRSPAQQESN CCCCCCCCHHHHHHH	30.62	22094256
41	Phosphorylation	RSPAQQESNQAEASK CCHHHHHHHHHHHHH	29.88	25850435
57	Ubiquitination	VAESNSCKFPAGIKI HHHHCCCCCCCCCEE	54.96	-
63	Acetylation	CKFPAGIKIINHPTM CCCCCCCEEECCCCC	36.29	115613807
140	Phosphorylation	RTEVTLETLGPKPAA CCEEEEECCCCCCCC	39.88	22210691
163	Sumoylation	PGALCEQKRETCADG CCCCCHHCCCCCCCC	29.88	28112733
189	Ubiquitination	SNIQWLRKMSSDGLG HHHHHHHHHCCCCCC	40.75	-
191	Phosphorylation	IQWLRKMSSDGLGSR HHHHHHHCCCCCCCH	28.45	30576142
192	Phosphorylation	QWLRKMSSDGLGSRS HHHHHHCCCCCCCHH	32.00	27251275
197	Phosphorylation	MSSDGLGSRSIKQEM HCCCCCCCHHHHHHH	28.09	27251275
201	Sumoylation	GLGSRSIKQEMEEKE CCCCHHHHHHHHHHH	41.26	-
201	Sumoylation	GLGSRSIKQEMEEKE CCCCHHHHHHHHHHH	41.26	28112733
218	Sumoylation	HLEQRQVKVEEPSRP CCEECCCCCCCCCCC	35.27	-
218	Sumoylation	HLEQRQVKVEEPSRP CCEECCCCCCCCCCC	35.27	-
251	Phosphorylation	MIQFAINSTERKRMT HHHHHHCCCHHCCCC	26.07	-
252	Phosphorylation	IQFAINSTERKRMTL HHHHHCCCHHCCCCH	35.01	-
278	"N6,N6-dimethyllysine"	PYFKHIAKPGWKNSI CHHHHCCCCCHHHHH	43.38	-
278	Methylation	PYFKHIAKPGWKNSI CHHHHCCCCCHHHHH	43.38	23644510
278	Ubiquitination	PYFKHIAKPGWKNSI CHHHHCCCCCHHHHH	43.38	-
282	"N6,N6-dimethyllysine"	HIAKPGWKNSIRHNL HCCCCCHHHHHHHCC	46.89	-
282	Methylation	HIAKPGWKNSIRHNL HCCCCCHHHHHHHCC	46.89	23644510
284	Phosphorylation	AKPGWKNSIRHNLSL CCCCHHHHHHHCCCH	19.78	28188228
306	Phosphorylation	TSANGKVSFWTIHPS ECCCCCEEEEEECCC	20.67	26074081
309	Phosphorylation	NGKVSFWTIHPSANR CCCEEEEEECCCCCC	13.85	26074081
313	Phosphorylation	SFWTIHPSANRYLTL EEEEECCCCCCEEEH	24.82	26074081
317	Phosphorylation	IHPSANRYLTLDQVF ECCCCCCEEEHHHCC	12.12	26074081
319	Phosphorylation	PSANRYLTLDQVFKP CCCCCEEEHHHCCCC	21.25	26074081
325	Sumoylation	LTLDQVFKPLDPGSP EEHHHCCCCCCCCCC	45.90	28112733
331	Phosphorylation	FKPLDPGSPQLPEHL CCCCCCCCCCCHHHH	18.17	22094256
340	Phosphorylation	QLPEHLESQQKRPNP CCHHHHHHHHCCCCH	44.25	29523821
354	Phosphorylation	PELRRNMTIKTELPL HHHHHCCEECCCCCC	23.91	24719451
356	Sumoylation	LRRNMTIKTELPLGA HHHCCEECCCCCCCC	27.12	-
356	Sumoylation	LRRNMTIKTELPLGA HHHCCEECCCCCCCC	27.12	28112733
357	Phosphorylation	RRNMTIKTELPLGAR HHCCEECCCCCCCCH	38.61	24719451
376	Phosphorylation	PLLPRVSSYLVPIQF CCCCCHHEEEEEEEC	21.45	17101782
422	Sumoylation	KRVRIAPKVLLAEEG CCCEECCHHHHHCCC	36.17	-
422	Acetylation	KRVRIAPKVLLAEEG CCCEECCHHHHHCCC	36.17	115613803
422	Sumoylation	KRVRIAPKVLLAEEG CCCEECCHHHHHCCC	36.17	28112733
422	Ubiquitination	KRVRIAPKVLLAEEG CCCEECCHHHHHCCC	36.17	-
434	Phosphorylation	EEGIAPLSSAGPGKE CCCCCCHHHCCCCCH	19.65	28555341
435	Phosphorylation	EGIAPLSSAGPGKEE CCCCCHHHCCCCCHH	44.95	28555341
440	Sumoylation	LSSAGPGKEEKLLFG HHHCCCCCHHEEECC	66.87	-
440	Acetylation	LSSAGPGKEEKLLFG HHHCCCCCHHEEECC	66.87	115613805
440	Sumoylation	LSSAGPGKEEKLLFG HHHCCCCCHHEEECC	66.87	28112733
440	Ubiquitination	LSSAGPGKEEKLLFG HHHCCCCCHHEEECC	66.87	-
443	Ubiquitination	AGPGKEEKLLFGEGF CCCCCHHEEECCCCC	52.13	-
451	Phosphorylation	LLFGEGFSPLLPVQT EECCCCCCCCCCCEE	26.04	22094256
460	Sumoylation	LLPVQTIKEEEIQPG CCCCEECCHHHCCCC	63.56	-
460	Sumoylation	LLPVQTIKEEEIQPG CCCCEECCHHHCCCC	63.56	-
478	Sumoylation	PHLARPIKVESPPLE CCCCCCCCCCCCCHH	42.50	-
478	Sumoylation	PHLARPIKVESPPLE CCCCCCCCCCCCCHH	42.50	-
481	Phosphorylation	ARPIKVESPPLEEWP CCCCCCCCCCHHHCC	34.50	30266825
489	Phosphorylation	PPLEEWPSPAPSFKE CCHHHCCCCCCCCCC	34.46	22094256
495	Sumoylation	PSPAPSFKEESSHSW CCCCCCCCCCCCCCC	65.98	-
495	Sumoylation	PSPAPSFKEESSHSW CCCCCCCCCCCCCCC	65.98	-
501	Phosphorylation	FKEESSHSWEDSSQS CCCCCCCCCCCCCCC	33.82	20363803
505	Phosphorylation	SSHSWEDSSQSPTPR CCCCCCCCCCCCCCC	20.82	25627689
506	Phosphorylation	SHSWEDSSQSPTPRP CCCCCCCCCCCCCCC	47.18	25627689
508	Phosphorylation	SWEDSSQSPTPRPKK CCCCCCCCCCCCCCC	32.46	20363803
510	Phosphorylation	EDSSQSPTPRPKKSY CCCCCCCCCCCCCCC	36.86	22094256
516	Phosphorylation	PTPRPKKSYSGLRSP CCCCCCCCCCCCCCC	30.56	29396449
517	Phosphorylation	TPRPKKSYSGLRSPT CCCCCCCCCCCCCCC	18.68	21712546
518	Phosphorylation	PRPKKSYSGLRSPTR CCCCCCCCCCCCCCC	38.14	29396449
522	Phosphorylation	KSYSGLRSPTRCVSE CCCCCCCCCCCHHHH	35.35	22094256
524	Phosphorylation	YSGLRSPTRCVSEML CCCCCCCCCHHHHHH	37.64	29396449
581	Phosphorylation	ELPFPADSSDPASQL CCCCCCCCCCCHHHC	38.45	22199227
582	Phosphorylation	LPFPADSSDPASQLS CCCCCCCCCCHHHCC	48.43	22199227
586	Phosphorylation	ADSSDPASQLSYSQE CCCCCCHHHCCCCCC	36.72	22199227
589	Phosphorylation	SDPASQLSYSQEVGG CCCHHHCCCCCCCCC	18.33	22199227
590	Phosphorylation	DPASQLSYSQEVGGP CCHHHCCCCCCCCCC	23.98	22199227
591	Phosphorylation	PASQLSYSQEVGGPF CHHHCCCCCCCCCCC	19.25	22199227
596 (in isoform 2)	Phosphorylation	-	29.64	15024056
600	Phosphorylation	EVGGPFKTPIKETLP CCCCCCCCCCCCCCC	30.53	22094256
603	Sumoylation	GPFKTPIKETLPISS CCCCCCCCCCCCCCC	45.94	-
603	Acetylation	GPFKTPIKETLPISS CCCCCCCCCCCCCCC	45.94	115613799
603	Sumoylation	GPFKTPIKETLPISS CCCCCCCCCCCCCCC	45.94	-
605	Phosphorylation	FKTPIKETLPISSTP CCCCCCCCCCCCCCC	32.60	22199227
609	Phosphorylation	IKETLPISSTPSKSV CCCCCCCCCCCCCCC	26.64	30266825
610	Phosphorylation	KETLPISSTPSKSVL CCCCCCCCCCCCCCC	45.09	30266825
611	Phosphorylation	ETLPISSTPSKSVLP CCCCCCCCCCCCCCC	25.45	30266825
613	Phosphorylation	LPISSTPSKSVLPRT CCCCCCCCCCCCCCC	37.34	30266825
614	Acetylation	PISSTPSKSVLPRTP CCCCCCCCCCCCCCC	45.87	115613801
615	Phosphorylation	ISSTPSKSVLPRTPE CCCCCCCCCCCCCCC	32.97	26074081
620	Phosphorylation	SKSVLPRTPESWRLT CCCCCCCCCCCCCCC	29.48	22094256
623	Phosphorylation	VLPRTPESWRLTPPA CCCCCCCCCCCCCCC	20.78	25159151
627	Phosphorylation	TPESWRLTPPAKVGG CCCCCCCCCCCEECC	20.74	22094256
638	Phosphorylation	KVGGLDFSPVQTSQG EECCCCCCCCCCCCC	24.67	22094256
660	Phosphorylation	PLGLMDLSTTPLQSA CCCCCCCCCCCCCCC	26.43	29523821
661	Phosphorylation	LGLMDLSTTPLQSAP CCCCCCCCCCCCCCC	39.47	29523821
662	Phosphorylation	GLMDLSTTPLQSAPP CCCCCCCCCCCCCCC	20.73	29523821
666	Phosphorylation	LSTTPLQSAPPLESP CCCCCCCCCCCCCCC	50.88	29523821
672	Phosphorylation	QSAPPLESPQRLLSS CCCCCCCCCCHHHCC	33.73	22094256
678	Phosphorylation	ESPQRLLSSEPLDLI CCCCHHHCCCCCCEE	36.93	30177828
679	Phosphorylation	SPQRLLSSEPLDLIS CCCHHHCCCCCCEEE	43.11	30177828
686	Phosphorylation	SEPLDLISVPFGNSS CCCCCEEECCCCCCC	30.91	29802988
692	Phosphorylation	ISVPFGNSSPSDIDV EECCCCCCCHHHCCC	43.96	29116813
693	Phosphorylation	SVPFGNSSPSDIDVP ECCCCCCCHHHCCCC	32.21	29116813
695	Phosphorylation	PFGNSSPSDIDVPKP CCCCCCHHHCCCCCC	49.50	28387310
704	Phosphorylation	IDVPKPGSPEPQVSG CCCCCCCCCCCCCCC	34.32	22094256
710	Phosphorylation	GSPEPQVSGLAANRS CCCCCCCCCCCCCCC	23.89	22199227
717	Phosphorylation	SGLAANRSLTEGLVL CCCCCCCCCCCCCCH	39.18	25159151
719	Phosphorylation	LAANRSLTEGLVLDT CCCCCCCCCCCCHHH	29.29	26055452
726	Phosphorylation	TEGLVLDTMNDSLSK CCCCCHHHCCHHHHH	17.45	26055452
730	Phosphorylation	VLDTMNDSLSKILLD CHHHCCHHHHHHHHH	29.54	25159151
732	Phosphorylation	DTMNDSLSKILLDIS HHCCHHHHHHHHHCC	22.92	22199227
739	Phosphorylation	SKILLDISFPGLDED HHHHHHCCCCCCCCC	25.67	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4	S	Phosphorylation	Kinase	CDK4	P11802	PSP
35	S	Phosphorylation	Kinase	CDK4	P11802	PSP
361	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
376	S	Phosphorylation	Kinase	CHEK2	O96017	Uniprot
451	S	Phosphorylation	Kinase	CDK6	Q00534	PSP
451	S	Phosphorylation	Kinase	CDK4	P11802	PSP
474	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
489	S	Phosphorylation	Kinase	CDK6	Q00534	PSP
489	S	Phosphorylation	Kinase	CDK4	P11802	PSP
508	S	Phosphorylation	Kinase	CDK6	Q00534	PSP
508	S	Phosphorylation	Kinase	CDK4	P11802	PSP
510	T	Phosphorylation	Kinase	CDK6	Q00534	PSP
510	T	Phosphorylation	Kinase	CDK4	P11802	PSP
522	S	Phosphorylation	Kinase	CDK4	P11802	PSP
522	S	Phosphorylation	Kinase	CDK6	Q00534	PSP
596	T	Phosphorylation	Kinase	CDK2	P24941	PSP
596	T	Phosphorylation	Kinase	CDK1	P06493	PSP
600	T	Phosphorylation	Kinase	CDK6	Q00534	PSP
600	T	Phosphorylation	Kinase	CDK4	P11802	PSP
600	T	Phosphorylation	Kinase	CDK1	P06493	PSP
611	T	Phosphorylation	Kinase	CDK6	Q00534	PSP
611	T	Phosphorylation	Kinase	CDK4	P11802	PSP
611	T	Phosphorylation	Kinase	CDK1	P06493	Uniprot
620	T	Phosphorylation	Kinase	CDK4	P11802	PSP
620	T	Phosphorylation	Kinase	CDK1	P06493	PSP
620	T	Phosphorylation	Kinase	CDK6	Q00534	PSP
627	T	Phosphorylation	Kinase	CDK6	Q00534	PSP
627	T	Phosphorylation	Kinase	CDK4	P11802	PSP
693	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot
704	S	Phosphorylation	Kinase	CDK6	Q00534	PSP
704	S	Phosphorylation	Kinase	CDK4	P11802	PSP
730	S	Phosphorylation	Kinase	PLK1	P53350	Uniprot
739	S	Phosphorylation	Kinase	PLK1	P53350	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:18573889

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FOXM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FOXM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBTB3_HUMAN	ZBTB3	physical	20211142
THIL_HUMAN	ACAT1	physical	22939629
OS9_HUMAN	OS9	physical	21988832
SP1_HUMAN	SP1	physical	23635401
SUMO1_HUMAN	SUMO1	physical	24362530
FZR1_HUMAN	FZR1	physical	24362530
FZR1_HUMAN	FZR1	physical	18758239
LIN9_HUMAN	LIN9	physical	25609649
MYBB_HUMAN	MYBL2	physical	25609649
LIN54_HUMAN	LIN54	physical	25609649
KIF22_HUMAN	KIF22	physical	25609649
LIN37_HUMAN	LIN37	physical	25609649
LRWD1_HUMAN	LRWD1	physical	25609649
ORC2_HUMAN	ORC2	physical	25609649
SMCA5_HUMAN	SMARCA5	physical	25609649
ZC11A_HUMAN	ZC3H11A	physical	25609649
SYDC_HUMAN	DARS	physical	25609649
PRC1_HUMAN	PRC1	physical	25609649
HERC5_HUMAN	HERC5	physical	25609649
SYIC_HUMAN	IARS	physical	25609649
BMS1_HUMAN	BMS1	physical	25609649
TRM1L_HUMAN	TRMT1L	physical	25609649
DDX52_HUMAN	DDX52	physical	25609649
DEP1A_HUMAN	DEPDC1	physical	25609649
DNJC9_HUMAN	DNAJC9	physical	25609649
ECT2_HUMAN	ECT2	physical	25609649
TF3C4_HUMAN	GTF3C4	physical	25609649
SYLC_HUMAN	LARS	physical	25609649
SYPM_HUMAN	PARS2	physical	25609649
PESC_HUMAN	PES1	physical	25609649
PRP8_HUMAN	PRPF8	physical	25609649
SYQ_HUMAN	QARS	physical	25609649
RBMX_HUMAN	RBMX	physical	25609649
SNUT1_HUMAN	SART1	physical	25609649
SMC2_HUMAN	SMC2	physical	25609649
U520_HUMAN	SNRNP200	physical	25609649
OTUB1_HUMAN	OTUB1	physical	26148240
OTUB1_HUMAN	OTUB1	physical	27167337
GSK3A_HUMAN	GSK3A	physical	26912724
GSK3B_HUMAN	GSK3B	physical	26912724
AXIN1_HUMAN	AXIN1	physical	26912724
FBXW7_HUMAN	FBXW7	physical	26912724
UBP5_HUMAN	USP5	physical	26912724
RN168_HUMAN	RNF168	physical	27526106
RNF8_HUMAN	RNF8	physical	27526106
UBP5_HUMAN	USP5	physical	28807830

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FOXM1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; THR-620 ANDTHR-627, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Plk1-dependent phosphorylation of FoxM1 regulates a transcriptionalprogramme required for mitotic progression."; Fu Z., Malureanu L., Huang J., Wang W., Li H., van Deursen J.M.,Tindall D.J., Chen J.; Nat. Cell Biol. 10:1076-1082(2008). Cited for: FUNCTION, PHOSPHORYLATION AT THR-611; SER-693; SER-730 AND SER-739,AND MUTAGENESIS OF THR-611; SER-693; SER-730 AND SER-739.	19160488 [Abstract]
"Chk2 mediates stabilization of the FoxM1 transcription factor tostimulate expression of DNA repair genes."; Tan Y., Raychaudhuri P., Costa R.H.; Mol. Cell. Biol. 27:1007-1016(2007). Cited for: FUNCTION IN DNA REPAIR, AND PHOSPHORYLATION AT SER-376 BY CHEK2.	17101782 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-704, AND MASSSPECTROMETRY.	15302935 [Abstract]