BMS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BMS1_HUMAN
• UniProt AC: Q14692
• Protein Name: Ribosome biogenesis protein BMS1 homolog
• Gene Name: BMS1
• Organism: Homo sapiens (Human).
• Sequence Length: 1282
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus..
• Protein Sequence: MEAKDQKKHRKKNSGPKAAKKKKRLLQDLQLGDEEDARKRNPKAFAVQSAVRMARSFHRTQDLKTKKHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIQCLIRNFTRQKLTEIRGPVTIVSGKKRRLTIIECGCDINMMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHGFPKIMGVLTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNLGRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDIRTNIKCDRKVSLYGYLRGAHLKNKSQIHMPGVGDFAVSDISFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVDLGGSHVFQDEVGPTHELVQSLISTHSTIDAKMASSRVTLFSDSKPLGSEDIDNQGLMMPKEEKQMDLNTGRMRRKAIFGDEDESGDSDDEEDDEMSEDDGLENGSSDEEAEEEENAEMTDQYMAVKGIKRRKLELEEDSEMDLPAFADSDDDLERSSAEEGEAEEADESSEEEDCTAGEKGISGSKAAGEGSKAGLSPANCQSDRVNLEKSLLMKKAALPTFDSGHCTAEEVFASEDESEESSSLSAEEEDSENEEAIRKKLSKPSQVSSGQKLGPQNFIDETSDIENLLKEEEDYKEENNDSKETSGALKWKEDLSRKAAEAFLRQQQAAPNLRKLIYGTVTEDNEEEDDDTLEELGGLFRVNQPDRECKHKADSLDCSRFLVEAPHDWDLEEVMNSIRDCFVTGKWEDDKDAAKVLAEDEELYGDFEDLETGDVHKGKSGPNTQNEDIEKEVKEEIDPDEEESAKKKHLDKKRKLKEMFDAEYDEGESTYFDDLKGEMQKQAQLNRAEFEDQDDEARVQYEGFRPGMYVRIEIENVPCEFVQNFDPHYPIILGGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPIIFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGAAFWGPITPQGTGFLAIQSVSGIMPDFRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEGAVIRTVSGIRGQIKKALRAPEGAFRASFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGEKDTWSGMRTTGQLRLAHGVRLKANKDSLYKPILRQKKHFNSLHIPKALQKALPFKNKPKTQAKAGKVPKDRRRPAVIREPHERKILALLDALSTVHSQKMKKAKEQRHLHNKEHFRAKQKEEEEKLKRQKDLRKKLFRIQGQKERRNQKSSLKGAEGQLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MEAKDQKKHRKKNS -CCHHHHHHHHHHCC	61.76	24816145
12	Acetylation	DQKKHRKKNSGPKAA HHHHHHHHCCCHHHH	57.19	7365617
17	Acetylation	RKKNSGPKAAKKKKR HHHCCCHHHHHHHHH	65.58	7365627
43	Sumoylation	DARKRNPKAFAVQSA HHHHHCHHHHHHHHH	60.74	28112733
49	Phosphorylation	PKAFAVQSAVRMARS HHHHHHHHHHHHHHH	23.33	19691289
52	Methylation	FAVQSAVRMARSFHR HHHHHHHHHHHHHHC	16.86	-
56	Phosphorylation	SAVRMARSFHRTQDL HHHHHHHHHHCCCCC	18.83	24043423
60	Phosphorylation	MARSFHRTQDLKTKK HHHHHHCCCCCCCCC	20.19	24043423
95	Ubiquitination	MGPPKVGKSTLIQCL ECCCCCCHHHHHHHH	43.16	-
110	Ubiquitination	IRNFTRQKLTEIRGP HHHHCHHCHHHCCCC	54.83	29967540
124	Acetylation	PVTIVSGKKRRLTII CEEEECCCCEEEEEE	35.28	25953088
124	Ubiquitination	PVTIVSGKKRRLTII CEEEECCCCEEEEEE	35.28	29967540
130	Ubiquitination	GKKRRLTIIECGCDI CCCEEEEEEECCCCH	2.71	27667366
188	Phosphorylation	GVLTHLDSFKHNKQL HHHHHHHHHHCHHHH	42.42	27067055
281	Phosphorylation	IKCDRKVSLYGYLRG CCCCCCCHHHHHHHC	20.93	28152594
283	Phosphorylation	CDRKVSLYGYLRGAH CCCCCHHHHHHHCCC	9.02	28152594
285	Phosphorylation	RKVSLYGYLRGAHLK CCCHHHHHHHCCCCC	4.62	25367160
333	Ubiquitination	RCLNEKEKLVYAPLS HCCCHHHCEEEECCC	55.08	29967540
382	Ubiquitination	SLISTHSTIDAKMAS HHHHCCCCCCHHHHC	18.44	22817900
384	Ubiquitination	ISTHSTIDAKMASSR HHCCCCCCHHHHCCC	39.98	22817900
393	Phosphorylation	KMASSRVTLFSDSKP HHHCCCEEEEECCCC	22.45	30576142
396	Phosphorylation	SSRVTLFSDSKPLGS CCCEEEEECCCCCCC	44.05	25850435
398	Phosphorylation	RVTLFSDSKPLGSED CEEEEECCCCCCCCC	34.67	25850435
399	Sumoylation	VTLFSDSKPLGSEDI EEEEECCCCCCCCCC	49.61	28112733
403	Phosphorylation	SDSKPLGSEDIDNQG ECCCCCCCCCCCCCC	39.52	25850435
415	Sumoylation	NQGLMMPKEEKQMDL CCCCCCCHHHHCCCC	61.68	-
415	Sumoylation	NQGLMMPKEEKQMDL CCCCCCCHHHHCCCC	61.68	28112733
441	Ubiquitination	GDEDESGDSDDEEDD CCCCCCCCCCCCCCC	59.16	22817900
446	Ubiquitination	SGDSDDEEDDEMSED CCCCCCCCCCCCCCC	77.18	22817900
494	Phosphorylation	KLELEEDSEMDLPAF CCCCCCCCCCCCCCC	37.79	27470641
504	Phosphorylation	DLPAFADSDDDLERS CCCCCCCCCCHHHHH	39.24	30266825
511	Phosphorylation	SDDDLERSSAEEGEA CCCHHHHHHHHCCCH	25.23	25137130
512	Phosphorylation	DDDLERSSAEEGEAE CCHHHHHHHHCCCHH	46.01	25137130
524	Phosphorylation	EAEEADESSEEEDCT CHHHCCCCCCCCCCC	43.53	25137130
525	Phosphorylation	AEEADESSEEEDCTA HHHCCCCCCCCCCCC	47.16	25137130
535	Acetylation	EDCTAGEKGISGSKA CCCCCCCCCCCCCCC	61.70	26051181
541	Ubiquitination	EKGISGSKAAGEGSK CCCCCCCCCCCCCCC	45.86	27667366
547	Phosphorylation	SKAAGEGSKAGLSPA CCCCCCCCCCCCCCC	18.28	28111955
548	Acetylation	KAAGEGSKAGLSPAN CCCCCCCCCCCCCCC	58.28	25953088
552	Phosphorylation	EGSKAGLSPANCQSD CCCCCCCCCCCCCCC	22.50	29255136
558	Phosphorylation	LSPANCQSDRVNLEK CCCCCCCCCCCCHHH	29.59	25159151
560	Methylation	PANCQSDRVNLEKSL CCCCCCCCCCHHHHH	25.19	-
565	2-Hydroxyisobutyrylation	SDRVNLEKSLLMKKA CCCCCHHHHHHHHHH	49.96	-
566	Phosphorylation	DRVNLEKSLLMKKAA CCCCHHHHHHHHHHC	19.84	21712546
617	Ubiquitination	EEAIRKKLSKPSQVS HHHHHHHCCCHHHCC	9.99	27667366
618	Phosphorylation	EAIRKKLSKPSQVSS HHHHHHCCCHHHCCC	51.94	23312004
621	Phosphorylation	RKKLSKPSQVSSGQK HHHCCCHHHCCCCCC	47.12	24732914
624	Phosphorylation	LSKPSQVSSGQKLGP CCCHHHCCCCCCCCC	22.55	24732914
624	Ubiquitination	LSKPSQVSSGQKLGP CCCHHHCCCCCCCCC	22.55	23000965
625	Phosphorylation	SKPSQVSSGQKLGPQ CCHHHCCCCCCCCCC	46.52	25159151
627	Ubiquitination	PSQVSSGQKLGPQNF HHHCCCCCCCCCCCC	39.48	23000965
638	Phosphorylation	PQNFIDETSDIENLL CCCCCCCCHHHHHHH	28.14	25159151
639	Phosphorylation	QNFIDETSDIENLLK CCCCCCCHHHHHHHH	34.25	25159151
646	Sumoylation	SDIENLLKEEEDYKE HHHHHHHHHHHHHHH	67.27	28112733
651	Phosphorylation	LLKEEEDYKEENNDS HHHHHHHHHHHCCCC	24.47	29632367
658	Phosphorylation	YKEENNDSKETSGAL HHHHCCCCCHHHHHH	34.22	24732914
661	Phosphorylation	ENNDSKETSGALKWK HCCCCCHHHHHHHHH	35.88	24144214
662	Phosphorylation	NNDSKETSGALKWKE CCCCCHHHHHHHHHH	24.14	24144214
668	Acetylation	TSGALKWKEDLSRKA HHHHHHHHHHHHHHH	39.50	26051181
694	Phosphorylation	PNLRKLIYGTVTEDN CCHHHHHHEECCCCC	19.72	28176443
696	Phosphorylation	LRKLIYGTVTEDNEE HHHHHHEECCCCCCC	13.79	28176443
698	Phosphorylation	KLIYGTVTEDNEEED HHHHEECCCCCCCCC	37.14	24732914
708	Phosphorylation	NEEEDDDTLEELGGL CCCCCCCHHHHHCHH	42.96	28176443
728	Ubiquitination	PDRECKHKADSLDCS CCHHHCCCCCCCCHH	39.11	29967540
731	Phosphorylation	ECKHKADSLDCSRFL HHCCCCCCCCHHHHH	30.85	28674419
736	Ubiquitination	ADSLDCSRFLVEAPH CCCCCHHHHHEECCC	34.94	27667366
762	Ubiquitination	RDCFVTGKWEDDKDA HHHHHHCCCCCCHHH	37.74	29967540
771	Ubiquitination	EDDKDAAKVLAEDEE CCCHHHHHHHHCCHH	39.23	29967540
780	Phosphorylation	LAEDEELYGDFEDLE HHCCHHHHCCHHHCC	20.23	28796482
788	Phosphorylation	GDFEDLETGDVHKGK CCHHHCCCCCCCCCC	46.08	-
793	Acetylation	LETGDVHKGKSGPNT CCCCCCCCCCCCCCC	68.81	26051181
793	Ubiquitination	LETGDVHKGKSGPNT CCCCCCCCCCCCCCC	68.81	22817900
795	Ubiquitination	TGDVHKGKSGPNTQN CCCCCCCCCCCCCCC	57.98	22817900
796	Phosphorylation	GDVHKGKSGPNTQNE CCCCCCCCCCCCCCH	69.06	29449344
800	Phosphorylation	KGKSGPNTQNEDIEK CCCCCCCCCCHHHHH	35.59	21815630
810	Sumoylation	EDIEKEVKEEIDPDE HHHHHHHHHHCCCCH	51.20	-
810	Sumoylation	EDIEKEVKEEIDPDE HHHHHHHHHHCCCCH	51.20	25114211
820	Phosphorylation	IDPDEEESAKKKHLD CCCCHHHHHHHHHHH	48.98	25159151
836	Ubiquitination	KRKLKEMFDAEYDEG HHHHHHHHHHCCCCC	9.38	24816145
840	Phosphorylation	KEMFDAEYDEGESTY HHHHHHCCCCCCCCC	22.48	27642862
852	Ubiquitination	STYFDDLKGEMQKQA CCCHHHHHHHHHHHH	60.87	22817900
857	Ubiquitination	DLKGEMQKQAQLNRA HHHHHHHHHHHHHHH	46.41	22817900
860	Ubiquitination	GEMQKQAQLNRAEFE HHHHHHHHHHHHHHC	36.45	22817900
864	Ubiquitination	KQAQLNRAEFEDQDD HHHHHHHHHHCCCCH	25.42	22817900
885	Phosphorylation	EGFRPGMYVRIEIEN CCCCCCEEEEEEEEC	7.78	26074081
933	Acetylation	LKKHRWYKKILKSRD HHHHHHHHHHHHCCC	26.78	21339330
965	Ubiquitination	YIEDHNGRQRLLKYT EEECCCCCCHHHHCC	24.62	27667366
972	Ubiquitination	RQRLLKYTPQHMHCG CCHHHHCCCCCCCCC	18.19	23000965
975	Ubiquitination	LLKYTPQHMHCGAAF HHHCCCCCCCCCCEE	14.79	23000965
1028	Acetylation	IKIVKKLKLTGFPYK HHHHHHHCCCCCCCE	53.54	25953088
1028	Ubiquitination	IKIVKKLKLTGFPYK HHHHHHHCCCCCCCE	53.54	27667366
1035	Ubiquitination	KLTGFPYKIFKNTSF CCCCCCCEEECCCHH	41.74	23000965
1038	Ubiquitination	GFPYKIFKNTSFIKG CCCCEEECCCHHHHH	63.89	23000965
1041	Phosphorylation	YKIFKNTSFIKGMFN CEEECCCHHHHHHHC	34.07	24719451
1049	Phosphorylation	FIKGMFNSALEVAKF HHHHHHCHHHHHHHC	23.98	21406692
1063	Phosphorylation	FEGAVIRTVSGIRGQ CCCCEEEEHHCCHHH	14.11	-
1084	Ubiquitination	APEGAFRASFEDKLL CCCCCCCCCHHHHHH	16.48	27667366
1115	Phosphorylation	AFYNPVTSLLKPVGE HHCCCHHHCCCCCCC	31.75	24719451
1118	Methylation	NPVTSLLKPVGEKDT CCHHHCCCCCCCCCC	42.84	-
1130	Methylation	KDTWSGMRTTGQLRL CCCCCCCCCCCCHHH	32.44	-
1144	Methylation	LAHGVRLKANKDSLY HHCCCEEEECCCCCC	39.07	23644510
1147	Ubiquitination	GVRLKANKDSLYKPI CCEEEECCCCCCHHH	54.26	27667366
1149	Phosphorylation	RLKANKDSLYKPILR EEEECCCCCCHHHHH	34.90	23186163
1151	Phosphorylation	KANKDSLYKPILRQK EECCCCCCHHHHHCH	20.76	27642862
1152	Acetylation	ANKDSLYKPILRQKK ECCCCCCHHHHHCHH	30.76	23749302
1152	Ubiquitination	ANKDSLYKPILRQKK ECCCCCCHHHHHCHH	30.76	-
1158	Neddylation	YKPILRQKKHFNSLH CHHHHHCHHHHCCCC	41.61	32015554
1163	Phosphorylation	RQKKHFNSLHIPKAL HCHHHHCCCCCCHHH	22.00	24719451
1172	Ubiquitination	HIPKALQKALPFKNK CCCHHHHHHCCCCCC	53.38	29967540
1184	Ubiquitination	KNKPKTQAKAGKVPK CCCCCCHHHCCCCCC	14.64	24816145
1206	Sumoylation	IREPHERKILALLDA CCCHHHHHHHHHHHH	38.80	28112733
1208	Ubiquitination	EPHERKILALLDALS CHHHHHHHHHHHHHH	2.85	22817900
1212	Ubiquitination	RKILALLDALSTVHS HHHHHHHHHHHHHHH	46.44	22817900
1215	Phosphorylation	LALLDALSTVHSQKM HHHHHHHHHHHHHHH	30.06	21406692
1216	Phosphorylation	ALLDALSTVHSQKMK HHHHHHHHHHHHHHH	24.08	21406692
1219	Phosphorylation	DALSTVHSQKMKKAK HHHHHHHHHHHHHHH	27.45	21406692
1234	Ubiquitination	EQRHLHNKEHFRAKQ HHHHHCCHHHHHHHH	41.64	29967540
1247	Ubiquitination	KQKEEEEKLKRQKDL HHHHHHHHHHHHHHH	63.69	24816145
1271	Ubiquitination	QKERRNQKSSLKGAE HHHHHHHHHHCCCCC	45.63	22817900
1275	Methylation	RNQKSSLKGAEGQLQ HHHHHHCCCCCCCCC	59.01	-
1275	Ubiquitination	RNQKSSLKGAEGQLQ HHHHHHCCCCCCCCC	59.01	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BMS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BMS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BMS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RRS1_HUMAN	RRS1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 107600: Aplasia cutis congenita, non-syndromic (ACC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552; THR-638 ANDSER-639, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552; SER-625 ANDTHR-708, AND MASS SPECTROMETRY.
PubMed: 18669648

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-504; SER-552; SER-624;SER-625; SER-639 AND SER-820, AND MASS SPECTROMETRY.
PubMed: 19007248