TRM1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRM1L_HUMAN
• UniProt AC: Q7Z2T5
• Protein Name: TRMT1-like protein
• Gene Name: TRMT1L
• Organism: Homo sapiens (Human).
• Sequence Length: 733
• Protein Description: May play a role in motor coordination and exploratory behavior..
• Protein Sequence: MENMAEEELLPLEKEEVEVAQVQVPTPARDSAGVPAPAPDSALDSAPTPASAPAPAPALAQAPALSPSLASAPEEAKSKRHISIQRQLADLENLAFVTDGNFDSASSLNSDNLDAGNRQACPLCPKEKFRACNSHKLRRHLQNLHWKVSVEFEGYRMCICHLPCRPVKPNIIGEQITSKMGAHYHCIICSATITRRTDMLGHVRRHMNKGETKSSYIAASTAKPPKEILKEADTDVQVCPNYSIPQKTDSYFNPKMKLNRQLIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEKSDDILEEGEKNLGNIKVTKMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLHHGLDDIQTLIKTLIFESECTPQSQFSIHASSNVNKQEENGVFIKTTDDTTTDNYIAQGKRKSNEMITNLGKKQKTDVSTEHPPFYYNIHRHSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSILLKYSTPTYTGGQSESHVQSASEDTVTERVEMSVNDKAEASGCRRW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	VAQVQVPTPARDSAG EEEEECCCCCCCCCC	30.62	30266825
31	Phosphorylation	VPTPARDSAGVPAPA CCCCCCCCCCCCCCC	22.75	28634120
41	Phosphorylation	VPAPAPDSALDSAPT CCCCCCCCHHHCCCC	29.67	29449344
45	Phosphorylation	APDSALDSAPTPASA CCCCHHHCCCCCCCC	36.68	29449344
48	Phosphorylation	SALDSAPTPASAPAP CHHHCCCCCCCCCCC	31.07	29978859
51	Phosphorylation	DSAPTPASAPAPAPA HCCCCCCCCCCCCCH	35.67	29978859
66	Phosphorylation	LAQAPALSPSLASAP HHCCCCCCHHHHCCC	17.97	30278072
68	Phosphorylation	QAPALSPSLASAPEE CCCCCCHHHHCCCHH	32.94	30278072
71	Phosphorylation	ALSPSLASAPEEAKS CCCHHHHCCCHHHHH	50.04	30278072
126	Ubiquitination	QACPLCPKEKFRACN CCCCCCCHHHHHHCC	72.96	-
155	Phosphorylation	VSVEFEGYRMCICHL EEEEECCEEEEEEEC	6.49	-
213	Ubiquitination	HMNKGETKSSYIAAS HCCCCCCCHHHHHCC	32.86	-
215	Phosphorylation	NKGETKSSYIAASTA CCCCCCHHHHHCCCC	23.32	24719451
216	Phosphorylation	KGETKSSYIAASTAK CCCCCHHHHHCCCCC	11.15	27642862
220	Phosphorylation	KSSYIAASTAKPPKE CHHHHHCCCCCCCHH	21.63	28555341
221	Phosphorylation	SSYIAASTAKPPKEI HHHHHCCCCCCCHHH	33.69	27251275
223	Acetylation	YIAASTAKPPKEILK HHHCCCCCCCHHHHH	63.04	26051181
223	Ubiquitination	YIAASTAKPPKEILK HHHCCCCCCCHHHHH	63.04	-
242	Phosphorylation	DVQVCPNYSIPQKTD CCEECCCCCCCCCCC	7.97	21945579
243	Phosphorylation	VQVCPNYSIPQKTDS CEECCCCCCCCCCCC	34.14	21945579
247	Ubiquitination	PNYSIPQKTDSYFNP CCCCCCCCCCCCCCC	49.28	-
255	Ubiquitination	TDSYFNPKMKLNRQL CCCCCCCCCHHHHHH	50.17	-
302	Ubiquitination	KHLGNAVKVTINDLN HHHCCEEEEEEHHCC	31.11	-
324	Ubiquitination	QENCHLNKLKVVVDS EECCCCCCCEEEEEC	56.92	-
324	Acetylation	QENCHLNKLKVVVDS EECCCCCCCEEEEEC	56.92	26051181
326	Ubiquitination	NCHLNKLKVVVDSKE CCCCCCCEEEEECCC	34.29	-
346	Ubiquitination	DILEEGEKNLGNIKV HHHHHHHHHHCCEEE	69.22	-
352	Ubiquitination	EKNLGNIKVTKMDAN HHHHCCEEEEECCHH	48.10	-
355	Ubiquitination	LGNIKVTKMDANVLM HCCEEEEECCHHHHH	37.46	-
396	Phosphorylation	IRNLGIVSVTSTDIS HHHCCCEEEEECCHH	20.11	21406692
398	Phosphorylation	NLGIVSVTSTDISSL HCCCEEEEECCHHHH	20.57	21406692
399	Phosphorylation	LGIVSVTSTDISSLY CCCEEEEECCHHHHH	23.17	21406692
400	Phosphorylation	GIVSVTSTDISSLYA CCEEEEECCHHHHHH	28.17	21406692
403	Phosphorylation	SVTSTDISSLYAKAQ EEEECCHHHHHHHHH	19.66	21406692
404	Phosphorylation	VTSTDISSLYAKAQH EEECCHHHHHHHHHH	26.23	21406692
406	Phosphorylation	STDISSLYAKAQHVA ECCHHHHHHHHHHHH	14.17	21406692
426	Phosphorylation	CNIVRTEYYKELAAR CCCCCHHHHHHHHHH	21.15	-
427	Phosphorylation	NIVRTEYYKELAARI CCCCHHHHHHHHHHH	7.55	-
428	2-Hydroxyisobutyrylation	IVRTEYYKELAARIV CCCHHHHHHHHHHHH	45.40	-
498	Ubiquitination	CEERIFQKDGNMVEE HHHHHCCCCCCCCCC	57.78	-
508	Phosphorylation	NMVEENPYRQLPCNC CCCCCCCCCCCCCCC	23.67	-
542	Ubiquitination	LFNTGFLKRMLFESL HHCHHHHHHHHHHHH	33.24	-
585	Sumoylation	HASSNVNKQEENGVF EECCCCCCCHHCCEE	55.60	28112733
595	Phosphorylation	ENGVFIKTTDDTTTD HCCEEEECCCCCCCC	30.55	23312004
596	Phosphorylation	NGVFIKTTDDTTTDN CCEEEECCCCCCCCC	27.20	23312004
599	Phosphorylation	FIKTTDDTTTDNYIA EEECCCCCCCCCCHH	34.11	25627689
600	Phosphorylation	IKTTDDTTTDNYIAQ EECCCCCCCCCCHHC	38.86	25627689
601	Phosphorylation	KTTDDTTTDNYIAQG ECCCCCCCCCCHHCC	25.08	25262027
604	Phosphorylation	DDTTTDNYIAQGKRK CCCCCCCCHHCCCCH	10.63	23312004
609	Methylation	DNYIAQGKRKSNEMI CCCHHCCCCHHHHHH	44.57	115979459
609	Acetylation	DNYIAQGKRKSNEMI CCCHHCCCCHHHHHH	44.57	25953088
609	Ubiquitination	DNYIAQGKRKSNEMI CCCHHCCCCHHHHHH	44.57	-
611	Methylation	YIAQGKRKSNEMITN CHHCCCCHHHHHHHH	62.21	30996569
611	Ubiquitination	YIAQGKRKSNEMITN CHHCCCCHHHHHHHH	62.21	-
612	Phosphorylation	IAQGKRKSNEMITNL HHCCCCHHHHHHHHC	41.89	23927012
615	Sulfoxidation	GKRKSNEMITNLGKK CCCHHHHHHHHCCCC	5.53	21406390
617	Phosphorylation	RKSNEMITNLGKKQK CHHHHHHHHCCCCCC	24.07	23927012
621	Ubiquitination	EMITNLGKKQKTDVS HHHHHCCCCCCCCCC	56.02	-
621	Acetylation	EMITNLGKKQKTDVS HHHHHCCCCCCCCCC	56.02	25953088
644	Ubiquitination	NIHRHSIKGMNMPKL CHHHHCCCCCCCHHH	55.94	-
653	Acetylation	MNMPKLKKFLCYLSQ CCCHHHHHHHHHHHH	54.74	25953088
673	Sulfoxidation	SRTHFDPMGVRTDAP ECCCCCCCCCCCCCC	9.25	21406390
690	Ubiquitination	QFKSILLKYSTPTYT HHHHHHHHHCCCCCC	33.44	-
691	Phosphorylation	FKSILLKYSTPTYTG HHHHHHHHCCCCCCC	20.11	27732954
692	Phosphorylation	KSILLKYSTPTYTGG HHHHHHHCCCCCCCC	26.73	27732954
693	Phosphorylation	SILLKYSTPTYTGGQ HHHHHHCCCCCCCCC	19.29	23663014
695	Phosphorylation	LLKYSTPTYTGGQSE HHHHCCCCCCCCCCH	33.53	23663014
696	Phosphorylation	LKYSTPTYTGGQSES HHHCCCCCCCCCCHH	12.46	23663014
697	Phosphorylation	KYSTPTYTGGQSESH HHCCCCCCCCCCHHH	37.00	23663014
701	Phosphorylation	PTYTGGQSESHVQSA CCCCCCCCHHHCCCC	44.32	23401153
703	Phosphorylation	YTGGQSESHVQSASE CCCCCCHHHCCCCCC	33.92	23663014
707	Phosphorylation	QSESHVQSASEDTVT CCHHHCCCCCCCCCC	32.45	25159151
709	Phosphorylation	ESHVQSASEDTVTER HHHCCCCCCCCCCCE	41.05	27794612
712	Phosphorylation	VQSASEDTVTERVEM CCCCCCCCCCCEEEE	25.85	27794612
714	Phosphorylation	SASEDTVTERVEMSV CCCCCCCCCEEEECC	21.84	25850435
719	Sulfoxidation	TVTERVEMSVNDKAE CCCCEEEECCCHHHH	5.05	21406390
724	Ubiquitination	VEMSVNDKAEASGCR EEECCCHHHHHCCCC	42.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRM1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRM1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRM1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
VRK1_HUMAN	VRK1	physical	22939629
NTPCR_HUMAN	NTPCR	physical	26344197
TCEA1_HUMAN	TCEA1	physical	26344197
HNRPK_HUMAN	HNRNPK	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.