SYPM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYPM_HUMAN
• UniProt AC: Q7L3T8
• Protein Name: Probable proline--tRNA ligase, mitochondrial
• Gene Name: PARS2
• Organism: Homo sapiens (Human).
• Sequence Length: 475
• Subcellular Localization: Mitochondrion matrix .
• Protein Sequence: MEGLLTRCRALPALATCSRQLSGYVPCRFHHCAPRRGRRLLLSRVFQPQNLREDRVLSLQDKSDDLTCKSQRLMLQVGLIYPASPGCYHLLPYTVRAMEKLVRVIDQEMQAIGGQKVNMPSLSPAELWQATNRWDLMGKELLRLRDRHGKEYCLGPTHEEAITALIASQKKLSYKQLPFLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQQTYSLVCDAYCSLFNKLGLPFVKVQADVGTIGGTVSHEFQLPVDIGEDRLAICPRCSFSANMETLDLSQMNCPACQGPLTKTKGIEVGHTFYLGTKYSSIFNAQFTNVCGKPTLAEMGCYGLGVTRILAAAIEVLSTEDCVRWPSLLAPYQACLIPPKKGSKEQAASELIGQLYDHITEAVPQLHGEVLLDDRTHLTIGNRLKDANKFGYPFVIIAGKRALEDPAHFEVWCQNTGEVAFLTKDGVMDLLTPVQTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Methylation	PQNLREDRVLSLQDK CCCCCCCCEEECCCC	26.90	115486501
58	Phosphorylation	LREDRVLSLQDKSDD CCCCCEEECCCCCCC	22.56	29396449
88	Phosphorylation	YPASPGCYHLLPYTV EECCCCHHHHHHHHH	11.04	-
93	Phosphorylation	GCYHLLPYTVRAMEK CHHHHHHHHHHHHHH	20.17	-
139	Ubiquitination	NRWDLMGKELLRLRD CCHHHCCHHHHHHHH	31.09	21890473
170	Ubiquitination	TALIASQKKLSYKQL HHHHHHCCCCCHHHH	53.86	22817900
170	Acetylation	TALIASQKKLSYKQL HHHHHHCCCCCHHHH	53.86	25038526
171	Ubiquitination	ALIASQKKLSYKQLP HHHHHCCCCCHHHHH	34.72	22817900
171	Acetylation	ALIASQKKLSYKQLP HHHHHCCCCCHHHHH	34.72	25038526
175	Ubiquitination	SQKKLSYKQLPFLLY HCCCCCHHHHHHHHH	41.82	21890473
175	Acetylation	SQKKLSYKQLPFLLY HCCCCCHHHHHHHHH	41.82	25038526
331	Acetylation	QFTNVCGKPTLAEMG EEECCCCCCCHHHHC	29.69	25038526
430	Phosphorylation	KDANKFGYPFVIIAG HCCHHCCCCEEEEEE	9.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYPM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYPM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYPM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYEP_HUMAN	EPRS	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00172: L-Proline