NPA1P_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPA1P_HUMAN
• UniProt AC: O60287
• Protein Name: Nucleolar pre-ribosomal-associated protein 1
• Gene Name: URB1
• Organism: Homo sapiens (Human).
• Sequence Length: 2271
• Subcellular Localization: Nucleus, nucleolus .
• Protein Sequence: MGVPKRKASGGQDGAASSAGAAKRARKEELTGVRFKAQLKDPQGPGPGLEAFVSAAKKLPREDVYDVVEGYIKISVECVEIFQLLSGEKRPESETMLIFQVFEAILLRTASDLSHFHVVGTNIVKKLMNNHMKLICESLYASGYRLARACLSLMTAMVTQGPEAARDVCSHFDLNKKTLYTLVTKRDSKGVYDVRQAYVQFALSFLIAGDDSTIVQVLEVKEFIPCIFSSGIKEDRISTINILLSTLKTKVVHNKNITKTQKVRFFTGQLLNHIASLYNWNGITDVNPENVKVSAEEAGKTMVRELVHNFLMDLCCSLKHGINFYDASLGTFGRGGNLTLLHFLLGLKTAADDDLVADLVVNILKVCPDLLNKYFKEVTFSFIPRAKSTWLNNIKLLNKIYEAQPEISRAFQTREFIPLPRLLAMVMVTTVPLVCNKSMFTQALNLDSTSVRHTALSLISVILKRALKTVDHCLNKEVWQESGVYTAVMMEEFVQLFREALSKILPDLNTVVWVWQSLKKQETKQDDKKGQKRSDGPPAACDAHQCDDAETILLKAVLLQVICLYQKVVPHVVMQYNFDFSKLLKGVISEQGLREEVPPILQHHMLKVALELPASKFLWLKAQEGPDAEIIGGERSVFYLLMKMFVTSSHLQLKSLTKLLIMKILRDTGVFEHTWKELELWLEHLENTMEEDKETVIQFLERILLTLVANPYSYTDKASDFVQEASMLQATMTKQEADDMSIPISHIDDVLDMVDVLVEGSEGLDEEIGFTLSEDMILLTFPFSAVVPAALEARNKLLLGTGNEAAENVVTYLTAVLTDLLHTQRDPLALCLLLQAYDKLEPPCLVPCCQQLSRFNRYYSLWIPEQAREAWLLQAQGSPSPPALPLASSFTALLQAAYESQALRDEHIQVQLQATMPHLSMQQVLLAAKQVLLYLRSTVENFGQLGRSVGPPLLQLFLDLLRRLVVHCEQLDAQNQQRCEAARAEADLFLDMESVASLELANDQTLEEVLVAILRHPTLEGWFLALEQQALPPHTLSPVLVKLLATHFSAGVLQLLAASAPILQNIGQLGLLARYSEAITQSVLKELQNRRAGPATSPPKTPPQLEALQELHPYMEGAQLREVTLALLSLPETHLVTQQPTKSPGKERHLNALGKTLVQLLTCSPQDQLQSGELLWSSEYVRGLGALLPTLAVDELDTVLLHTLQRDPVLAPAVGADLLDYCLARRTQAALSIAALLLQESCTHLLWFEQWCLQAGPGLGLQGDLDDFLPLIHVYLQCRTRSHFTRPAGVSSAVIPVLRKTLWRQLQSRLLSTDSPPASGLYQEILAQLVPFARAKDLSVLMDRLPSLLHTPSSHKRWIVADSISAALEGSAEELCAWRRTLLESCVKWLIVSFSGGQQDDDNTQNQEKEMLLRLNALLHALNEVDPGDWQKFVKKGLKFRYQDHTFLKMLLTAVQLLYSPESSVRTKLIQLPVVYVMLMQHSLFLPTLLTSDGEESPDSQVKEALVDLMLTVVEMCPSVCESSHFAVLLGAYGATLSVLDQKILLLLRAYEQNKLSLINFRVLLWGPAAVEHHKTCRSLGRSLWQQPSVGDILRLLDRDRMMQTILHFPQNRRLLPPEDTQELIFKDKSRVDLDGLYDPCFLLQLFSELTRPEFVVDCRKFLDSNALGLTVTALSSYDPQMRAIAYHVLAAYYSHLEGARFQEQSQLLYLLDVVRNGIRTQDMRLTFTLALFIAKAALQILKPEEHMYLKVSNFLLSHEYLNMDKVPGFYQFFYSSDFEQKTEQKWVFGVLRQGIRDKQCYELCARRGIFHIILSFFHSPLCDEAAQNWILEILQNAAQVARSAYEIIRDYSLLTWILHILESKFLETPLLSNVISLLHTLWVTNLGDKAVEWESQRLCQPSSQEPAKRLALHLVNEFLYVLIVLMKHLRPTLAPVQLTNFFGTLDSVLRYRATVIQAFRDMNRFTVNETVLSTKDVLVLLHKWSLIERDLKLQEDLRAAIEKAQARELMKMLKDKNKPVMPARAKGPRGRKRRPGEAEEMADPELMASTLETCKGLLRSILTYWRPVIPGPDPTQEPVDSASPESDAPGPVYAAASLAVSWVLRSVAEHPLSRAEAAGLIGWLKSHILPHPVVVADLLKDSAVRSSIFRLYSRLCGAEGLAGPVQEVACLFNTVMLQLVAAQGRAGSPFHPAMEALSLSSLSEKDEATQASAAFLVSLYIKDIWLGAQRPDTLLTHVRMVCEAADDAPSSEEEAIVVLCKDAASAASDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MGVPKRKASGGQ ---CCCCCCCCCCCC	65.21	24467993
5	Ubiquitination	---MGVPKRKASGGQ ---CCCCCCCCCCCC	65.21	22817900
7	Ubiquitination	-MGVPKRKASGGQDG -CCCCCCCCCCCCCC	53.70	22817900
9	Phosphorylation	GVPKRKASGGQDGAA CCCCCCCCCCCCCHH	46.63	25849741
17	Phosphorylation	GGQDGAASSAGAAKR CCCCCHHHHHHHHHH	21.86	27251275
18	Phosphorylation	GQDGAASSAGAAKRA CCCCHHHHHHHHHHH	26.45	28176443
23	Acetylation	ASSAGAAKRARKEEL HHHHHHHHHHHHHHH	46.16	25953088
23	Ubiquitination	ASSAGAAKRARKEEL HHHHHHHHHHHHHHH	46.16	24816145
27	Sumoylation	GAAKRARKEELTGVR HHHHHHHHHHHCCCE	55.33	-
27	Sumoylation	GAAKRARKEELTGVR HHHHHHHHHHHCCCE	55.33	-
27	Ubiquitination	GAAKRARKEELTGVR HHHHHHHHHHHCCCE	55.33	29967540
36	Methylation	ELTGVRFKAQLKDPQ HHCCCEEEEECCCCC	25.34	115978929
36	Ubiquitination	ELTGVRFKAQLKDPQ HHCCCEEEEECCCCC	25.34	22817900
40	Ubiquitination	VRFKAQLKDPQGPGP CEEEEECCCCCCCCC	56.11	21906983
54	Phosphorylation	PGLEAFVSAAKKLPR CCHHHHHHHHHCCCH	18.96	25159151
57	Ubiquitination	EAFVSAAKKLPREDV HHHHHHHHCCCHHHH	55.34	21906983
58	Ubiquitination	AFVSAAKKLPREDVY HHHHHHHCCCHHHHH	60.02	22817900
73	"N6,N6-dimethyllysine"	DVVEGYIKISVECVE HHHHHEEEEEHHHHH	22.05	-
73	Methylation	DVVEGYIKISVECVE HHHHHEEEEEHHHHH	22.05	-
89	"N6,N6-dimethyllysine"	FQLLSGEKRPESETM HHHHCCCCCCCCHHH	76.43	-
89	Methylation	FQLLSGEKRPESETM HHHHCCCCCCCCHHH	76.43	-
109	Phosphorylation	FEAILLRTASDLSHF HHHHHHHHHHHCCCC	30.40	20068231
111	Phosphorylation	AILLRTASDLSHFHV HHHHHHHHHCCCCEE	38.17	20068231
114	Phosphorylation	LRTASDLSHFHVVGT HHHHHHCCCCEECCH	29.15	20068231
121	Phosphorylation	SHFHVVGTNIVKKLM CCCEECCHHHHHHHH	15.34	20068231
176	Acetylation	CSHFDLNKKTLYTLV HHHHCCCCCEEEEEE	55.20	25953088
177	Ubiquitination	SHFDLNKKTLYTLVT HHHCCCCCEEEEEEE	42.56	-
180	Phosphorylation	DLNKKTLYTLVTKRD CCCCCEEEEEEECCC	11.85	19664994
184	Phosphorylation	KTLYTLVTKRDSKGV CEEEEEEECCCCCCC	24.39	-
185	Ubiquitination	TLYTLVTKRDSKGVY EEEEEEECCCCCCCC	46.88	21963094
189	Ubiquitination	LVTKRDSKGVYDVRQ EEECCCCCCCCCHHH	57.60	21906983
233	Acetylation	CIFSSGIKEDRISTI HHHCCCCCCCHHHHH	58.02	26051181
248	Acetylation	NILLSTLKTKVVHNK HHHHHHHCCEEECCC	46.52	26051181
248	Ubiquitination	NILLSTLKTKVVHNK HHHHHHHCCEEECCC	46.52	21906983
250	Ubiquitination	LLSTLKTKVVHNKNI HHHHHCCEEECCCCC	40.44	22817900
255	Ubiquitination	KTKVVHNKNITKTQK CCEEECCCCCCCCCE	34.54	29967540
258	Phosphorylation	VVHNKNITKTQKVRF EECCCCCCCCCEEEH	37.12	28674151
300	Ubiquitination	VSAEEAGKTMVRELV CCHHHHHHHHHHHHH	40.26	22817900
373	Acetylation	VCPDLLNKYFKEVTF HCHHHHHHHHHHCHH	52.62	26051181
373	Ubiquitination	VCPDLLNKYFKEVTF HCHHHHHHHHHHCHH	52.62	22817900
376	Ubiquitination	DLLNKYFKEVTFSFI HHHHHHHHHCHHHCC	48.46	21906983
387	Ubiquitination	FSFIPRAKSTWLNNI HHCCCCCCCHHHHHH	50.09	29967540
395	Ubiquitination	STWLNNIKLLNKIYE CHHHHHHHHHHHHHH	49.39	21906983
399	Ubiquitination	NNIKLLNKIYEAQPE HHHHHHHHHHHHCHH	46.78	21906983
429	Phosphorylation	LLAMVMVTTVPLVCN HHHHHHHHHHHHHCC	12.18	-
430	Phosphorylation	LAMVMVTTVPLVCNK HHHHHHHHHHHHCCH	14.55	-
468	Ubiquitination	VILKRALKTVDHCLN HHHHHHHHHHHHHCC	45.58	29967540
469	O-linked_Glycosylation	ILKRALKTVDHCLNK HHHHHHHHHHHHCCH	31.83	29237092
517	Phosphorylation	TVVWVWQSLKKQETK HHHHHHHHHHHCCCC	26.83	-
534	Phosphorylation	DKKGQKRSDGPPAAC CCCCCCCCCCCCCCC	54.69	28555341
582	Ubiquitination	QYNFDFSKLLKGVIS HCCCCHHHHHHHHHC	58.81	22817900
585	Ubiquitination	FDFSKLLKGVISEQG CCHHHHHHHHHCCCC	62.66	21906983
589	Phosphorylation	KLLKGVISEQGLREE HHHHHHHCCCCHHHC	22.82	22210691
616	Ubiquitination	ALELPASKFLWLKAQ HHHCCHHHHHEECCC	46.73	21906983
621	Ubiquitination	ASKFLWLKAQEGPDA HHHHHEECCCCCCCC	36.12	21906983
712	Phosphorylation	LTLVANPYSYTDKAS HHHHHCCCCCCCCHH	17.70	28152594
713	Phosphorylation	TLVANPYSYTDKASD HHHHCCCCCCCCHHH	23.86	28152594
714	Phosphorylation	LVANPYSYTDKASDF HHHCCCCCCCCHHHH	17.08	28152594
715	Phosphorylation	VANPYSYTDKASDFV HHCCCCCCCCHHHHH	25.69	28152594
719	Phosphorylation	YSYTDKASDFVQEAS CCCCCCHHHHHHHHH	37.00	-
741	Phosphorylation	KQEADDMSIPISHID HHHHCCCCCCHHHHH	32.01	26074081
878	Phosphorylation	WLLQAQGSPSPPALP HHHHCCCCCCCCCCH	15.32	26074081
880	Phosphorylation	LQAQGSPSPPALPLA HHCCCCCCCCCCHHH	45.25	26074081
888	Phosphorylation	PPALPLASSFTALLQ CCCCHHHHHHHHHHH	33.40	20873877
889	Phosphorylation	PALPLASSFTALLQA CCCHHHHHHHHHHHH	22.47	20873877
891	Phosphorylation	LPLASSFTALLQAAY CHHHHHHHHHHHHHH	20.53	20873877
898	Phosphorylation	TALLQAAYESQALRD HHHHHHHHHHHHHHH	21.09	20873877
900	Phosphorylation	LLQAAYESQALRDEH HHHHHHHHHHHHHHC	14.21	20873877
934	Phosphorylation	AAKQVLLYLRSTVEN HHHHHHHHHHHHHHH	8.91	20068231
948	Phosphorylation	NFGQLGRSVGPPLLQ HHHHHHHCCCHHHHH	29.63	28258704
1075	Phosphorylation	QLGLLARYSEAITQS HHHHHHHHHHHHHHH	12.78	24076635
1080	Phosphorylation	ARYSEAITQSVLKEL HHHHHHHHHHHHHHH	23.10	24076635
1085	Ubiquitination	AITQSVLKELQNRRA HHHHHHHHHHHHCCC	54.98	21906983
1096	Phosphorylation	NRRAGPATSPPKTPP HCCCCCCCCCCCCCH	44.92	20873877
1097	Phosphorylation	RRAGPATSPPKTPPQ CCCCCCCCCCCCCHH	41.11	25159151
1100	Ubiquitination	GPATSPPKTPPQLEA CCCCCCCCCCHHHHH	76.64	21963094
1101	Phosphorylation	PATSPPKTPPQLEAL CCCCCCCCCHHHHHH	46.07	20873877
1114	Phosphorylation	ALQELHPYMEGAQLR HHHHHCCCCCCHHHH	9.32	20873877
1120	Phosphorylation	PYMEGAQLREVTLAL CCCCCHHHHHHHHHH	5.10	18669648
1124	Phosphorylation	GAQLREVTLALLSLP CHHHHHHHHHHHCCC	11.10	24732914
1129	Phosphorylation	EVTLALLSLPETHLV HHHHHHHCCCCCCCC	42.61	24732914
1133	Phosphorylation	ALLSLPETHLVTQQP HHHCCCCCCCCCCCC	20.69	24732914
1137	Phosphorylation	LPETHLVTQQPTKSP CCCCCCCCCCCCCCC	28.04	24732914
1141	Phosphorylation	HLVTQQPTKSPGKER CCCCCCCCCCCCHHH	39.55	24732914
1142	Ubiquitination	LVTQQPTKSPGKERH CCCCCCCCCCCHHHH	62.43	21906983
1143	Phosphorylation	VTQQPTKSPGKERHL CCCCCCCCCCHHHHH	41.17	21712546
1146	Ubiquitination	QPTKSPGKERHLNAL CCCCCCCHHHHHHHH	55.76	22817900
1312	Phosphorylation	QLQSRLLSTDSPPAS HHHHHHHCCCCCCCC	34.46	20068231
1313	Phosphorylation	LQSRLLSTDSPPASG HHHHHHCCCCCCCCC	40.23	20068231
1315	Phosphorylation	SRLLSTDSPPASGLY HHHHCCCCCCCCCHH	32.64	24719451
1319	Phosphorylation	STDSPPASGLYQEIL CCCCCCCCCHHHHHH	34.80	20068231
1322	Phosphorylation	SPPASGLYQEILAQL CCCCCCHHHHHHHHH	13.97	20068231
1336	Ubiquitination	LVPFARAKDLSVLMD HHHHHCHHHHHHHHH	54.36	22817900
1347	Phosphorylation	VLMDRLPSLLHTPSS HHHHCCHHHHCCCCC	48.42	-
1351	Phosphorylation	RLPSLLHTPSSHKRW CCHHHHCCCCCCCCE	25.49	-
1354	Phosphorylation	SLLHTPSSHKRWIVA HHHCCCCCCCCEEHH	33.94	-
1356	Acetylation	LHTPSSHKRWIVADS HCCCCCCCCEEHHHH	51.91	26051181
1356	Ubiquitination	LHTPSSHKRWIVADS HCCCCCCCCEEHHHH	51.91	29967540
1362	Phosphorylation	HKRWIVADSISAALE CCCEEHHHHHHHHHH	35.29	17081983
1365	Phosphorylation	WIVADSISAALEGSA EEHHHHHHHHHHCCH	16.08	-
1371	Phosphorylation	ISAALEGSAEELCAW HHHHHHCCHHHHHHH	24.11	22798277
1381	Phosphorylation	ELCAWRRTLLESCVK HHHHHHHHHHHHHHH	27.41	22798277
1385	Phosphorylation	WRRTLLESCVKWLIV HHHHHHHHHHHHHHH	24.95	22817900
1409	Ubiquitination	DNTQNQEKEMLLRLN CCCHHHHHHHHHHHH	38.36	22817900
1432	Acetylation	VDPGDWQKFVKKGLK CCCCHHHHHHHCCCC	48.12	26051181
1432	Ubiquitination	VDPGDWQKFVKKGLK CCCCHHHHHHHCCCC	48.12	21906983
1435	Ubiquitination	GDWQKFVKKGLKFRY CHHHHHHHCCCCCCC	44.23	22817900
1436	Ubiquitination	DWQKFVKKGLKFRYQ HHHHHHHCCCCCCCC	65.26	22817900
1459	Phosphorylation	LTAVQLLYSPESSVR HHHHHHHHCCCHHHH	30.67	-
1460	Phosphorylation	TAVQLLYSPESSVRT HHHHHHHCCCHHHHH	23.35	-
1555	Ubiquitination	LRAYEQNKLSLINFR HHHHHHCCCCCEEEE	38.86	21906983
1575	Ubiquitination	PAAVEHHKTCRSLGR HHHHHHHHHHHHHCC	51.75	21963094
1627	Ubiquitination	DTQELIFKDKSRVDL HHHHHHHCCCCCCCC	58.20	21906983
1629	Ubiquitination	QELIFKDKSRVDLDG HHHHHCCCCCCCCCC	40.53	22817900
1665	Phosphorylation	DCRKFLDSNALGLTV HHHHHHCCCCCCCEE	26.59	20860994
1753	Phosphorylation	EHMYLKVSNFLLSHE HHHHHHHHHHHHCCC	21.92	29978859
1758	Phosphorylation	KVSNFLLSHEYLNMD HHHHHHHCCCCCCCC	19.20	29978859
1761	Phosphorylation	NFLLSHEYLNMDKVP HHHHCCCCCCCCCCC	9.65	29978859
1766	Ubiquitination	HEYLNMDKVPGFYQF CCCCCCCCCCCCHHH	39.29	23503661
1771	Phosphorylation	MDKVPGFYQFFYSSD CCCCCCCHHHHCCCC	15.43	29978859
1775	Phosphorylation	PGFYQFFYSSDFEQK CCCHHHHCCCCHHHH	14.46	29978859
1776	Phosphorylation	GFYQFFYSSDFEQKT CCHHHHCCCCHHHHH	20.48	29978859
1777	Phosphorylation	FYQFFYSSDFEQKTE CHHHHCCCCHHHHHH	34.63	29978859
1782	Ubiquitination	YSSDFEQKTEQKWVF CCCCHHHHHHHHHHH	47.00	21906983
1786	Ubiquitination	FEQKTEQKWVFGVLR HHHHHHHHHHHHHHH	38.81	22817900
1799	Ubiquitination	LRQGIRDKQCYELCA HHHCCCHHHHHHHHH	32.21	21963094
1909	Acetylation	PSSQEPAKRLALHLV CCCCHHHHHHHHHHH	59.67	25953088
1909	Ubiquitination	PSSQEPAKRLALHLV CCCCHHHHHHHHHHH	59.67	21963094
1967	Phosphorylation	FRDMNRFTVNETVLS HHHCCCCCCCCCCCC	21.13	20068231
1971	Phosphorylation	NRFTVNETVLSTKDV CCCCCCCCCCCHHHH	22.88	20068231
1974	Phosphorylation	TVNETVLSTKDVLVL CCCCCCCCHHHHHHH	29.13	20068231
1975	Phosphorylation	VNETVLSTKDVLVLL CCCCCCCHHHHHHHH	27.40	20068231
1976	Ubiquitination	NETVLSTKDVLVLLH CCCCCCHHHHHHHHH	42.33	21906983
1986	Phosphorylation	LVLLHKWSLIERDLK HHHHHHHHHHHHHHH	25.03	-
1993	Ubiquitination	SLIERDLKLQEDLRA HHHHHHHHHHHHHHH	53.03	21906983
2004	Ubiquitination	DLRAAIEKAQARELM HHHHHHHHHHHHHHH	39.42	27667366
2012	Ubiquitination	AQARELMKMLKDKNK HHHHHHHHHHHHCCC	54.42	-
2019	Ubiquitination	KMLKDKNKPVMPARA HHHHHCCCCCCCCCC	44.74	29967540
2056	Ubiquitination	ASTLETCKGLLRSIL HHHHHHHHHHHHHHH	61.07	-
2107	Phosphorylation	AVSWVLRSVAEHPLS HHHHHHHHHHHCCCC	22.86	24719451
2141	2-Hydroxyisobutyrylation	VVVADLLKDSAVRSS CHHHHHHCCHHHHHH	57.86	-
2141	Ubiquitination	VVVADLLKDSAVRSS CHHHHHHCCHHHHHH	57.86	21963094
2148	Phosphorylation	KDSAVRSSIFRLYSR CCHHHHHHHHHHHHH	18.38	24719451
2154	Phosphorylation	SSIFRLYSRLCGAEG HHHHHHHHHHHCCCC	24.30	24719451
2199	Phosphorylation	HPAMEALSLSSLSEK CHHHHHHCCCCCCCC	33.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPA1P_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPA1P_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPA1P_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NPA1P_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1385, AND MASSSPECTROMETRY.
PubMed: 17081983