ELOV1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELOV1_HUMAN
• UniProt AC: Q9BW60
• Protein Name: Elongation of very long chain fatty acids protein 1 {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000305}
• Gene Name: ELOVL1 {ECO:0000255|HAMAP-Rule:MF_03201}
• Organism: Homo sapiens (Human).
• Sequence Length: 279
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs..
• Protein Sequence: MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAVVNLY -------CHHHHHHH	7.23	22223895
1	Sulfoxidation	-------MEAVVNLY -------CHHHHHHH	7.23	28465586
22	Phosphorylation	ADPRIQGYPLMGSPL CCCCCCCCCCCCCHH	4.10	24043423
27	Phosphorylation	QGYPLMGSPLLMTSI CCCCCCCCHHHHHHH	9.82	24043423
32	Phosphorylation	MGSPLLMTSILLTYV CCCHHHHHHHHHHHH	16.76	24043423
33	Phosphorylation	GSPLLMTSILLTYVY CCHHHHHHHHHHHHH	9.40	24043423
37	Phosphorylation	LMTSILLTYVYFVLS HHHHHHHHHHHHHHH	13.90	24043423
38	Phosphorylation	MTSILLTYVYFVLSL HHHHHHHHHHHHHHH	7.97	24043423
40	Phosphorylation	SILLTYVYFVLSLGP HHHHHHHHHHHHHCH	4.23	24043423
44	Phosphorylation	TYVYFVLSLGPRIMA HHHHHHHHHCHHHHC	26.44	24043423
54	Ubiquitination	PRIMANRKPFQLRGF HHHHCCCCCCEECCE	50.41	21890473
54	Ubiquitination	PRIMANRKPFQLRGF HHHHCCCCCCEECCE	50.41	27667366
65	Phosphorylation	LRGFMIVYNFSLVAL ECCEEEECCHHHHHH	10.28	22210691
68	Phosphorylation	FMIVYNFSLVALSLY EEEECCHHHHHHHHH	20.49	22210691
73	Phosphorylation	NFSLVALSLYIVYEF CHHHHHHHHHHHHHH	14.91	22210691
83	Phosphorylation	IVYEFLMSGWLSTYT HHHHHHHCCCHHHCE	29.03	22210691
117	Phosphorylation	VAWLFLFSKFIELMD HHHHHHHHHHHHHHH	28.89	24719451
117	Ubiquitination	VAWLFLFSKFIELMD HHHHHHHHHHHHHHH	28.89	21890473
171	Ubiquitination	GSFHAMINSSVHVIM HHHHHHHHHHHHHHH	18.36	21890473
194	Ubiquitination	FGPVAQPYLWWKKHM CCCCCCCCHHHHHHH	11.68	33845483
198	Ubiquitination	AQPYLWWKKHMTAIQ CCCCHHHHHHHHHHH	22.63	21890473
248	Ubiquitination	TIFFMLFSNFWYHSY HHHHHHHHCHHHHHH	27.44	33845483
275	Ubiquitination	NGAPGIAKVKAN--- CCCCCCCCCCCC---	42.20	33845483
277	Ubiquitination	APGIAKVKAN----- CCCCCCCCCC-----	41.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELOV1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELOV1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELOV1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSD10_HUMAN	PSMD10	physical	17353931
TWF2_HUMAN	TWF2	physical	17353931
CERS2_HUMAN	CERS2	physical	20937905
DHB12_HUMAN	HSD17B12	physical	20937905
TECR_HUMAN	TECR	physical	20937905

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.