PRS10_MOUSE - dbPTM
PRS10_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRS10_MOUSE
UniProt AC P62334
Protein Name 26S proteasome regulatory subunit 10B
Gene Name Psmc6
Organism Mus musculus (Mouse).
Sequence Length 389
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
Protein Sequence MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Malonylation-MADPRDKALQDYRK
-CCCHHHHHHHHHHH		52.8826320211
7Ubiquitination-MADPRDKALQDYRK
-CCCHHHHHHHHHHH		52.88-
20AcetylationRKKLLEHKEIDGRLK
HHHHHHCHHHHHHHH		47.1723954790
20UbiquitinationRKKLLEHKEIDGRLK
HHHHHHCHHHHHHHH		47.1722790023
34UbiquitinationKELREQLKELTKQYE
HHHHHHHHHHHHHHH		50.8222790023
38UbiquitinationEQLKELTKQYEKSEN
HHHHHHHHHHHHCHH		64.6022790023
48AcetylationEKSENDLKALQSVGQ
HHCHHHHHHHHHHHH		50.3323954790
48UbiquitinationEKSENDLKALQSVGQ
HHCHHHHHHHHHHHH		50.3322790023
62AcetylationQIVGEVLKQLTEEKF
HHHHHHHHHHCCCCE		48.7323954790
72AcetylationTEEKFIVKATNGPRY
CCCCEEEECCCCCEE		44.6822826441
72UbiquitinationTEEKFIVKATNGPRY
CCCCEEEECCCCCEE		44.6822790023
83GlutathionylationGPRYVVGCRRQLDKS
CCEEEEEECHHCCHH		1.8824333276
91UbiquitinationRRQLDKSKLKPGTRV
CHHCCHHHCCCCCEE		67.29-
168UbiquitinationRVGIIPPKGCLLYGP
HCCEECCCCEEEECC		57.8322790023
170GlutathionylationGIIPPKGCLLYGPPG
CEECCCCEEEECCCC		2.7124333276
173PhosphorylationPPKGCLLYGPPGTGK
CCCCEEEECCCCCCH		18.0322817900
180UbiquitinationYGPPGTGKTLLARAV
ECCCCCCHHHHHHHH		35.5222790023
193S-nitrosylationAVASQLDCNFLKVVS
HHHHHCCCCHHHHHC		5.4320925432
193S-palmitoylationAVASQLDCNFLKVVS
HHHHHCCCCHHHHHC		5.4328526873
193S-nitrosocysteineAVASQLDCNFLKVVS
HHHHHCCCCHHHHHC		5.43-
197UbiquitinationQLDCNFLKVVSSSIV
HCCCCHHHHHCHHHH		36.1322790023
200PhosphorylationCNFLKVVSSSIVDKY
CCHHHHHCHHHHHHH		22.7317242355
206MalonylationVSSSIVDKYIGESAR
HCHHHHHHHHHHHHH		28.0726320211
206UbiquitinationVSSSIVDKYIGESAR
HCHHHHHHHHHHHHH		28.07-
206AcetylationVSSSIVDKYIGESAR
HCHHHHHHHHHHHHH		28.0723806337
207PhosphorylationSSSIVDKYIGESARL
CHHHHHHHHHHHHHH		15.0817242355
244PhosphorylationAIGGRRFSEGTSADR
CCCCCCCCCCCCHHH		33.0526060331
247PhosphorylationGRRFSEGTSADREIQ
CCCCCCCCCHHHHHH		19.3829472430
248PhosphorylationRRFSEGTSADREIQR
CCCCCCCCHHHHHHH		38.7429472430
274UbiquitinationFDTLHRVKMIMATNR
CCHHHHHHHHHHCCC		23.7522790023
314UbiquitinationQARLDILKIHAGPIT
HHHCCEEEECCCCCC		32.5522790023
328PhosphorylationTKHGEIDYEAIVKLS
CCCCCCCHHHEEECC		16.9622817900
369UbiquitinationVVQEDFMKAVRKVAD
ECCHHHHHHHHHHHC		43.6622790023
383UbiquitinationDSKKLESKLDYKPV-
CHHHHHHHCCCCCC-		35.68-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRS10_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRS10_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRS10_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PRS10_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRS10_MOUSE

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Related Literatures of Post-Translational Modification

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