INGR1_MOUSE - dbPTM
INGR1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INGR1_MOUSE
UniProt AC P15261
Protein Name Interferon gamma receptor 1 {ECO:0000312|MGI:MGI:107655}
Gene Name Ifngr1 {ECO:0000312|MGI:MGI:107655}
Organism Mus musculus (Mouse).
Sequence Length 477
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG). [PubMed: 2530582]
Protein Sequence MGPQAAAGRMILLVVLMLSAKVGSGALTSTEDPEPPSVPVPTNVLIKSYNLNPVVCWEYQNMSQTPIFTVQVKVYSGSWTDSCTNISDHCCNIYEQIMYPDVSAWARVKAKVGQKESDYARSKEFLMCLKGKVGPPGLEIRRKKEEQLSVLVFHPEVVVNGESQGTMFGDGSTCYTFDYTVYVEHNRSGEILHTKHTVEKEECNETLCELNISVSTLDSRYCISVDGISSFWQVRTEKSKDVCIPPFHDDRKDSIWILVVAPLTVFTVVILVFAYWYTKKNSFKRKSIMLPKSLLSVVKSATLETKPESKYSLVTPHQPAVLESETVICEEPLSTVTAPDSPEAAEQEELSKETKALEAGGSTSAMTPDSPPTPTQRRSFSLLSSNQSGPCSLTAYHSRNGSDSGLVGSGSSISDLESLPNNNSETKMAEHDPPPVRKAPMASGYDKPHMLVDVLVDVGGKESLMGYRLTGEAQELS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
61N-linked_GlycosylationVVCWEYQNMSQTPIF
EEEEEEECCCCCCEE		31.04-
85N-linked_GlycosylationSWTDSCTNISDHCCN
CCCCCCCCCHHHHCC		35.77-
287PhosphorylationKNSFKRKSIMLPKSL
CCCCCCCCCCCCHHH		19.7725266776
292UbiquitinationRKSIMLPKSLLSVVK
CCCCCCCHHHHHHHH		50.1822790023
293PhosphorylationKSIMLPKSLLSVVKS
CCCCCCHHHHHHHHH		32.3827180971
296PhosphorylationMLPKSLLSVVKSATL
CCCHHHHHHHHHCCC		30.1127180971
299UbiquitinationKSLLSVVKSATLETK
HHHHHHHHHCCCCCC		32.0222790023
300PhosphorylationSLLSVVKSATLETKP
HHHHHHHHCCCCCCC		18.1825266776
302PhosphorylationLSVVKSATLETKPES
HHHHHHCCCCCCCCC		32.0222942356
305PhosphorylationVKSATLETKPESKYS
HHHCCCCCCCCCCCE		55.8229472430
362PhosphorylationKALEAGGSTSAMTPD
HHHHCCCCCCCCCCC		20.4721082442
363PhosphorylationALEAGGSTSAMTPDS
HHHCCCCCCCCCCCC		24.6325619855
364PhosphorylationLEAGGSTSAMTPDSP
HHCCCCCCCCCCCCC		20.1025619855
367PhosphorylationGGSTSAMTPDSPPTP
CCCCCCCCCCCCCCC		24.5421082442
370PhosphorylationTSAMTPDSPPTPTQR
CCCCCCCCCCCCCCC		33.7025521595
373PhosphorylationMTPDSPPTPTQRRSF
CCCCCCCCCCCCCCE		42.2125521595
375PhosphorylationPDSPPTPTQRRSFSL
CCCCCCCCCCCCEEC		36.8725521595
379PhosphorylationPTPTQRRSFSLLSSN
CCCCCCCCEECCCCC		22.7526824392
381PhosphorylationPTQRRSFSLLSSNQS
CCCCCCEECCCCCCC		29.6427742792
384PhosphorylationRRSFSLLSSNQSGPC
CCCEECCCCCCCCCE		32.3225293948
385PhosphorylationRSFSLLSSNQSGPCS
CCEECCCCCCCCCEE		38.5725293948
388PhosphorylationSLLSSNQSGPCSLTA
ECCCCCCCCCEEEEE		49.2925293948
392PhosphorylationSNQSGPCSLTAYHSR
CCCCCCEEEEEEECC		31.7125293948
394PhosphorylationQSGPCSLTAYHSRNG
CCCCEEEEEEECCCC		14.6319060867
396PhosphorylationGPCSLTAYHSRNGSD
CCEEEEEEECCCCCC		8.6226032504
398PhosphorylationCSLTAYHSRNGSDSG
EEEEEEECCCCCCCC		18.1121743459
402PhosphorylationAYHSRNGSDSGLVGS
EEECCCCCCCCCCCC		31.9527087446
404PhosphorylationHSRNGSDSGLVGSGS
ECCCCCCCCCCCCCC		35.4127087446
409PhosphorylationSDSGLVGSGSSISDL
CCCCCCCCCCCHHHH		28.2019060867
411PhosphorylationSGLVGSGSSISDLES
CCCCCCCCCHHHHHH		26.6223984901
412PhosphorylationGLVGSGSSISDLESL
CCCCCCCCHHHHHHC		29.6322817900
414PhosphorylationVGSGSSISDLESLPN
CCCCCCHHHHHHCCC		37.7825266776
418PhosphorylationSSISDLESLPNNNSE
CCHHHHHHCCCCCCC		57.3223984901
424PhosphorylationESLPNNNSETKMAEH
HHCCCCCCCCCCCCC		49.0920531401
426PhosphorylationLPNNNSETKMAEHDP
CCCCCCCCCCCCCCC		26.4120531401
445PhosphorylationKAPMASGYDKPHMLV
CCCCCCCCCCCCEEE		20.4915522878
467PhosphorylationGKESLMGYRLTGEAQ
CHHCCCCEEECCCHH		6.6215522878
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INGR1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INGR1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INGR1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
JAK2_MOUSEJak2physical
7499845
RN19B_MOUSERnf19bphysical
27570112
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INGR1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370 AND THR-373, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, AND MASSSPECTROMETRY.

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