RN19B_MOUSE - dbPTM
RN19B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RN19B_MOUSE
UniProt AC A2A7Q9
Protein Name E3 ubiquitin-protein ligase RNF19B
Gene Name Rnf19b
Organism Mus musculus (Mouse).
Sequence Length 732
Subcellular Localization Cytoplasmic granule membrane
Multi-pass membrane protein . Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death (By similarity)..
Protein Sequence MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTFHSVFSASARGRRARTKPQAEPPPPAAPPPPPPPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEEDEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MGSEKDSESP
-----CCCCCCCCCC		39.9325266776
12PhosphorylationKDSESPRSTSLHAAA
CCCCCCCCCCCCCCC		26.2330635358
13PhosphorylationDSESPRSTSLHAAAP
CCCCCCCCCCCCCCC		36.2723140645
14PhosphorylationSESPRSTSLHAAAPD
CCCCCCCCCCCCCCC		21.2823140645
507PhosphorylationLSVMQGPYSETASFA
CCEECCCCCCCCCEE		26.4325777480
508PhosphorylationSVMQGPYSETASFAA
CEECCCCCCCCCEEH		31.4425777480
510PhosphorylationMQGPYSETASFAALS
ECCCCCCCCCEEHHH		22.9725777480
512PhosphorylationGPYSETASFAALSGG
CCCCCCCCEEHHHCC		23.8825777480
517PhosphorylationTASFAALSGGTLSGG
CCCEEHHHCCEECCC		30.3725777480
520PhosphorylationFAALSGGTLSGGILS
EEHHHCCEECCCEEC		22.6725777480
522PhosphorylationALSGGTLSGGILSSG
HHHCCEECCCEECCC		34.5125777480
527PhosphorylationTLSGGILSSGKGKYS
EECCCEECCCCCCCE		34.8125777480
528PhosphorylationLSGGILSSGKGKYSR
ECCCEECCCCCCCEE		40.8725777480
551PhosphorylationKEIFPKDTASLGAIS
HHHCCCCCCCCCCCC		25.0328066266
553PhosphorylationIFPKDTASLGAISDS
HCCCCCCCCCCCCCC		29.4528066266
558PhosphorylationTASLGAISDSASTRA
CCCCCCCCCCHHHHH		25.6128066266
560PhosphorylationSLGAISDSASTRAMA
CCCCCCCCHHHHHHC		19.8228066266
562PhosphorylationGAISDSASTRAMAGS
CCCCCCHHHHHHCHH		23.5228066266
563PhosphorylationAISDSASTRAMAGSI
CCCCCHHHHHHCHHH		23.3628066266
666PhosphorylationAQPESIRSDLESSDT
CCHHHHHHHHHCCCC		44.8925293948
670PhosphorylationSIRSDLESSDTQSDD
HHHHHHHCCCCCCCC		40.5925293948
671PhosphorylationIRSDLESSDTQSDDV
HHHHHHCCCCCCCCC		34.9925293948
673PhosphorylationSDLESSDTQSDDVPD
HHHHCCCCCCCCCCC		31.7425293948
675PhosphorylationLESSDTQSDDVPDIT
HHCCCCCCCCCCCCC		37.5625293948
682PhosphorylationSDDVPDITSDECGSP
CCCCCCCCCCCCCCC		37.1925293948
683PhosphorylationDDVPDITSDECGSPR
CCCCCCCCCCCCCCC		31.5730635358
688PhosphorylationITSDECGSPRSHAAA
CCCCCCCCCCCCCCC		28.8830635358
698PhosphorylationSHAAACPSTPQVHGA
CCCCCCCCCCCCCCC		53.2425266776
699PhosphorylationHAAACPSTPQVHGAP
CCCCCCCCCCCCCCC		11.6825266776
707PhosphorylationPQVHGAPSPSAHKNL
CCCCCCCCCHHHCCC		30.8425266776
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RN19B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RN19B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RN19B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RN19B_MOUSE

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Related Literatures of Post-Translational Modification

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