VAV_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VAV_MOUSE
• UniProt AC: P27870
• Protein Name: Proto-oncogene vav
• Gene Name: Vav1
• Organism: Mus musculus (Mouse).
• Sequence Length: 845
• Protein Description: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation..
• Protein Sequence: MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPQAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALNDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRLESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELFSVHTHFLKELKDALAGPGATTLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDATEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRHGQDFAGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVHPYVHGPPQDLSVHLWYAGPMERAGAEGILTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLLELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAISKPPAGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	QDFGKVIYTLSALSW HHHHHHHHHHHHCCC	12.48	25367039
111	Phosphorylation	DFGKVIYTLSALSWT HHHHHHHHHHHCCCC	11.78	25367039
142	Phosphorylation	ALNDEDIYSGLSDQI CCCCHHHHCCCHHHC	14.70	10669745
160	Phosphorylation	AEEDEDLYDCVENEE CCCCCCHHHHHHCCC	21.44	10669745
174	Phosphorylation	EAEGDEIYEDLMRLE CCCCCHHHHHHHCCC	11.01	10669745
182	Phosphorylation	EDLMRLESVPTPPKM HHHHCCCCCCCCCCC	37.68	25159016
185	Phosphorylation	MRLESVPTPPKMTEY HCCCCCCCCCCCCHH	50.49	27180971
192	Phosphorylation	TPPKMTEYDKRCCCL CCCCCCHHHHHHHHH	20.00	-
245	Phosphorylation	VNIEELFSVHTHFLK ECHHHHHHHHHHHHH	26.13	28978645
265	Phosphorylation	LAGPGATTLYQVFIK HCCCCCCCHHHHHHH	23.96	25367039
267	Phosphorylation	GPGATTLYQVFIKYK CCCCCCHHHHHHHHH	10.67	22817900
283	Phosphorylation	RFLVYGRYCSQVESA HHHHCCCHHHHHHHH	7.65	30635358
285	Phosphorylation	LVYGRYCSQVESASK HHCCCHHHHHHHHHH	28.46	30635358
289	Phosphorylation	RYCSQVESASKHLDQ CHHHHHHHHHHHHHH	38.70	30635358
291	Phosphorylation	CSQVESASKHLDQVA HHHHHHHHHHHHHHH	29.86	30635358
321	Phosphorylation	RANNGRFTLRDLLMV HHHCCCCCHHHHHHH	21.37	24719451
423	Phosphorylation	RRSKTDRYAFLLDKA CCCCCHHHHHHHHHH	12.43	-
541	Phosphorylation	MLLRGTFYQGYRCYR HHHHCCCCCCEEEEE	10.81	-
544	Phosphorylation	RGTFYQGYRCYRCRA HCCCCCCEEEEEECC	5.08	-
547	Phosphorylation	FYQGYRCYRCRAPAH CCCCEEEEEECCCCC	12.07	-
574	Phosphorylation	HGQDFAGTMKKDKLH CCCCCCHHHCHHHHH	23.53	26824392
587	Acetylation	LHRRAQDKKRNELGL HHHHHHHHHHHHCCC	41.37	7923493
588	Acetylation	HRRAQDKKRNELGLP HHHHHHHHHHHCCCC	69.60	7923503
658	Phosphorylation	PCNRVHPYVHGPPQD ECCCCCCCCCCCCCC	7.09	-
692	Phosphorylation	LTNRSDGTYLVRQRV EECCCCCCEEEEEEE	20.76	29176673
745	Phosphorylation	LLELVEFYQQNSLKD HHHHHHHHHHCCHHH	8.83	-
756	Phosphorylation	SLKDCFKSLDTTLQF CHHHHHHHCCCCCCC	15.95	29472430
759	Phosphorylation	DCFKSLDTTLQFPYK HHHHHCCCCCCCCCC	34.40	29472430
760	Phosphorylation	CFKSLDTTLQFPYKE HHHHCCCCCCCCCCC	20.44	29472430
780	Phosphorylation	ISKPPAGSTKYFGTA CCCCCCCCCCEEEEH	24.67	25266776
781	Phosphorylation	SKPPAGSTKYFGTAK CCCCCCCCCEEEEHH	28.92	29472430
791	Phosphorylation	FGTAKARYDFCARDR EEEHHHHEEECCCCC	20.45	-
802	Phosphorylation	ARDRSELSLKEGDII CCCCCCCCCCCCCEE	33.09	22817900
826	Phosphorylation	GWWRGEIYGRIGWFP CEECCEEEEECCCCH	8.96	29899451
834	Phosphorylation	GRIGWFPSNYVEEDY EECCCCHHHHCCCCH	31.17	25367039
836	Phosphorylation	IGWFPSNYVEEDYSE CCCCHHHHCCCCHHH	17.36	25159016
841	Phosphorylation	SNYVEEDYSEYC--- HHHCCCCHHHCC---	13.49	25159016
842	Phosphorylation	NYVEEDYSEYC---- HHCCCCHHHCC----	34.12	25159016
844	Phosphorylation	VEEDYSEYC------ CCCCHHHCC------	9.49	2069873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
142	Y	Phosphorylation	Kinase	LCK	P06239	PSP
142	Y	Phosphorylation	Kinase	LCK	P06240	PhosphoELM
160	Y	Phosphorylation	Kinase	LCK	P06239	PSP
160	Y	Phosphorylation	Kinase	LCK	P06240	PhosphoELM
174	Y	Phosphorylation	Kinase	LCK	P06239	PSP
174	Y	Phosphorylation	Kinase	LCK	P06240	PhosphoELM
174	Y	Phosphorylation	Kinase	SRC	P12931	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Cbl	P22682	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VAV_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VAV_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITK_MOUSE	Itk	genetic	19009524
MK14_MOUSE	Mapk14	physical	9064344
CD3Z_MOUSE	Cd247	physical	9064344
CD3E_MOUSE	Cd3e	physical	9064344
ZAP70_MOUSE	Zap70	physical	26936881

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-844, AND MASSSPECTROMETRY.
PubMed: 17947660