CUL5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CUL5_MOUSE
• UniProt AC: Q9D5V5
• Protein Name: Cullin-5
• Gene Name: Cul5
• Organism: Mus musculus (Mouse).
• Sequence Length: 780
• Protein Description: Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor..
• Protein Sequence: MATSNLLKNKGSLQFEDKWDFMHPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGSSKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQSSNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSVNQDFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQMEWLIEHRYIRRDEADINTFIYMA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATSNLLKNK -----CCCCHHHCCC	19.49	25777480
4	Phosphorylation	----MATSNLLKNKG ----CCCCHHHCCCC	18.88	25777480
12	Phosphorylation	NLLKNKGSLQFEDKW HHHCCCCCCCCCCCH	22.17	22817900
34	Phosphorylation	LKLLRQESVTKQQWF HHHHHCCCCCHHHHH	27.09	25338131
36	Phosphorylation	LLRQESVTKQQWFDL HHHCCCCCHHHHHHH	32.20	22324799
74	Ubiquitination	EDILEFIKQAQARVL HHHHHHHHHHHHHHH	44.92	-
109	Phosphorylation	TQCDILPKPFCQLEV HHCCCCCCCCEEEEE	47.48	24719451
146	Phosphorylation	MLDTWNESIFSNIKN HHHHCCHHHHHHHHH	26.22	25338131
194	Ubiquitination	LCSNPEDKLQIYRDN CCCCHHHHHHHHHHH	40.40	-
210	Phosphorylation	EKAYLDSTERFYRTQ HHHHHHCCCHHHHCC	30.74	20139300
230	Phosphorylation	QQNGVQNYMKYADAK HHCCHHHHHHHHHHH	4.29	-
232	Ubiquitination	NGVQNYMKYADAKLK CCHHHHHHHHHHHCH	27.25	-
302	Acetylation	LMFSLMDKVPNGIEP HHHHHHHCCCCCCHH	45.70	7610909
312	Acetylation	NGIEPMLKDLEEHII CCCHHHHHHHHHHHH	54.75	7610921
346	Phosphorylation	KYVEQLLTLFNRFSK HHHHHHHHHHHHHHH	37.58	22817900
492	Acetylation	MPADYVNKLARMFQD CCHHHHHHHHHHHHH	33.22	23954790
537	Phosphorylation	ILNAGAWSRSSEKVF EECCCCCCCCCCCEE	23.04	26643407
539	Phosphorylation	NAGAWSRSSEKVFVS CCCCCCCCCCCEEEE	37.02	26643407
540	Phosphorylation	AGAWSRSSEKVFVSL CCCCCCCCCCEEEEC	40.08	26643407
633	Phosphorylation	PDAELRRTLWSLVAF CCHHHHHHHHHHHHC	26.58	27180971
724	Ubiquitination	EAIIQIMKMRKKISN HHHHHHHHHHHHCCC	36.86	-
728	Ubiquitination	QIMKMRKKISNAQLQ HHHHHHHHCCCHHHH	40.79	-
730	Phosphorylation	MKMRKKISNAQLQTE HHHHHHCCCHHHHHH	34.69	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CUL5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CUL5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CUL5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOCS1_MOUSE	Socs1	physical	19385048
SOCS2_MOUSE	Socs2	physical	19385048
SOCS3_MOUSE	Socs3	physical	19385048
SOCS4_MOUSE	Socs4	physical	19385048
SOCS5_MOUSE	Socs5	physical	19385048
SOCS6_MOUSE	Socs6	physical	19385048
SOCS7_MOUSE	Socs7	physical	19385048
CISH_MOUSE	Cish	physical	19385048
BCAR1_MOUSE	Bcar1	physical	24284072

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.