SOCS4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOCS4_MOUSE
• UniProt AC: Q91ZA6
• Protein Name: Suppressor of cytokine signaling 4
• Gene Name: Socs4
• Organism: Mus musculus (Mouse).
• Sequence Length: 436
• Protein Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity)..
• Protein Sequence: MAENNSKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESCSESEAIGTVENVEIPLRSQERQLSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSGRHSPGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTVPMSPNSDEWVSADLSERKLRDAQLKRRNTEDDIPCFSHTNGQPCVITANSASCTGGHITGSMMNLVTNNSIEDSDMDSEDEIITLCTSSRKRNKPRWEMEEEILQLEAPPKFHTQIDYVHCLVPDLLQISNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSPMKLYLKEYHYKSKVRLLRIDVPEQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAENNSKNVDVRP --CCCCCCCCCCCCC	36.87	-
27	Phosphorylation	SADRKDGYVWSGKKL CCCCCCCEEECCCCC	14.63	29514104
67	Phosphorylation	RSQERQLSCSSIELD CCCCCCCCCCEEEEE	12.01	-
69	Phosphorylation	QERQLSCSSIELDLD CCCCCCCCEEEEECC	30.86	-
70	Phosphorylation	ERQLSCSSIELDLDH CCCCCCCEEEEECCC	25.14	-
78	Phosphorylation	IELDLDHSCGHRFLG EEEECCCCCCHHHHC	22.81	-
110	Phosphorylation	KNCSGRHSPGLPSKR CCCCCCCCCCCCCCC	21.21	25338131
148	Phosphorylation	WHFIKRHTVPMSPNS EEEHHHCCCCCCCCC	30.27	30482847
413	Acetylation	LPIPSPMKLYLKEYH CCCCCCCEEEEEECC	37.05	7712053
422	Acetylation	YLKEYHYKSKVRLLR EEEECCCCCCEEEEE	30.41	7712065
426	Methylation	YHYKSKVRLLRIDVP CCCCCCEEEEECCCC	31.57	30989395

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOCS4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOCS4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOCS4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELOC_HUMAN	TCEB1	physical	19385048
ELOB_HUMAN	TCEB2	physical	19385048

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.