SOCS5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOCS5_MOUSE
• UniProt AC: O54928
• Protein Name: Suppressor of cytokine signaling 5
• Gene Name: Socs5
• Organism: Mus musculus (Mouse).
• Sequence Length: 536
• Protein Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling..
• Protein Sequence: MDKVGKMWNNLKYRCQNLFSHEGGSRNENVEMNPNRCPSVKEKSISLGEAAPQQESSPLRENVALQLGLSPSKTFSRRNQNCAAEIPQVVEISIEKDSDSGATPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDTEKKFGRTRSGLQRRERRYGVSSMQDMDSVSSRAVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGSAIPQTNCDSEEDSTTLCLQSRRQKQRQVSGDSHAHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	MNPNRCPSVKEKSIS CCCCCCCCCHHHHCC	49.82	30482847
44	Phosphorylation	CPSVKEKSISLGEAA CCCCHHHHCCHHCCC	20.64	28638064
46	Phosphorylation	SVKEKSISLGEAAPQ CCHHHHCCHHCCCCC	37.10	28638064
56	Phosphorylation	EAAPQQESSPLRENV CCCCCCCCCCCHHHH	32.68	23984901
57	Phosphorylation	AAPQQESSPLRENVA CCCCCCCCCCHHHHH	27.48	23984901
70	Phosphorylation	VALQLGLSPSKTFSR HHHHCCCCHHHHCCC	25.90	25338131
166	Phosphorylation	SSMQDMDSVSSRAVG CCCCCHHHHHHHHHC	19.77	-
168	Phosphorylation	MQDMDSVSSRAVGSR CCCHHHHHHHHHCCH	20.33	24759943
169	Phosphorylation	QDMDSVSSRAVGSRS CCHHHHHHHHHCCHH	23.31	-
188	S-palmitoylation	LQDTVGLCFPMRTYS HHHHHHHCCCCCCCC	2.71	28680068
203	Phosphorylation	KQSKPLFSNKRKIHL CCCCCCCCCCCCCCH	49.47	29514104
211	Phosphorylation	NKRKIHLSELMLEKC CCCCCCHHHHHHHCC	17.96	-
224	Phosphorylation	KCPFPAGSDLAQKWH CCCCCCCCHHHHHHH	31.40	-
344	Phosphorylation	RQKQRQVSGDSHAHV HHHHHHHCCCCCCHH	28.66	30387612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOCS5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOCS5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOCS5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELOC_HUMAN	TCEB1	physical	19385048
ELOB_HUMAN	TCEB2	physical	19385048
JAK3_HUMAN	JAK3	physical	23990909

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.