SOCS7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOCS7_MOUSE
• UniProt AC: Q8VHQ2
• Protein Name: Suppressor of cytokine signaling 7
• Gene Name: Socs7
• Organism: Mus musculus (Mouse).
• Sequence Length: 579
• Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Nucleus . Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon
• Protein Description: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)..
• Protein Sequence: MVFRNVGRPPEEEDAEAAREPGPSELLCPRHRCALDPKALPPGLALERTWGPVAGLEAQLAALGLGQPAGPGIKTAGGGCCPCPCPPQPPPPQPPPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGVGGRLLLQPPGPELPPVPFPLQDLVPPGRLSRGEQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGDLAASAASLTDMGGSAVRELDTGRKPRLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRASESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQEVEPST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
419	Phosphorylation	LKGKPDGSFLVRDSS HCCCCCCCEEEECCC	23.84	29176673
433	Phosphorylation	SDPRYILSLSFRSQG CCCCEEEEEEECCCC	16.65	26370283
435	Phosphorylation	PRYILSLSFRSQGIT CCEEEEEEECCCCCC	18.42	26370283
559	Phosphorylation	YDPQEEVYLSLKEAQ CCCHHHHEEEHHHHH	8.21	25293948
561	Phosphorylation	PQEEVYLSLKEAQLI CHHHHEEEHHHHHHH	21.51	25293948
569	Phosphorylation	LKEAQLISKQKQEVE HHHHHHHHHHHCCCC	37.31	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOCS7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOCS7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOCS7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELOC_HUMAN	TCEB1	physical	19385048
ELOB_HUMAN	TCEB2	physical	19385048
VINEX_MOUSE	Sorbs3	physical	15242778

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.