dbPTM

VINEX_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VINEX_MOUSE
UniProt AC	Q9R1Z8
Protein Name	Vinexin
Gene Name	Sorbs3
Organism	Mus musculus (Mouse).
Sequence Length	733
Subcellular Localization	Cell junction, focal adhesion. Cell junction. Cytoplasm, cytoskeleton. Localized at focal adhesion sites, cell-cell junctions and cell-extracellular matrix junctions.
Protein Description	Promotes up-regulation of actin stress fiber formation..
Protein Sequence	MARILGVGRSSASSLNNKEDNESDVALLSPKDPNRVHTKEQLAHPASSNLDPSMQGLPAGLSLDDFIPGHLRTHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGCPPPRRDGSLNPDPAWYQTWPGPGSRPSMSPKPPASQHAQNWSATWTKDSKRQDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFQQIHRKMPDLQLDWTLEDPPKVVSARASSAEPRHLGTLQRPASRPGTTETSSGRNWNHSEETSRNTFNYNFRPSSSGLHPPNQVPRHREKVENVWTEDSWNQFLHELETGHKPKKPLVDDPVEKPAQPIEVLLERELAKLSAELDKDLRAIETRLPSPKNSQAPRRPLEQPGLEQQPSARLSSAWRPNSPHAPYFSSSRPLSPHRMADGGGSPFLGRRDFVYPSSAREPSASERGSSPSRKEEKKRKAARLKFDFQAQSPKELSLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGDAVAQYTFKGDLEVELSFRKGERICLIRKVNEHWYEGRITGTGRQGIFPASYVQINREPRLRLCDDGPQLPASPNPTTTAHLSSHSHPSSIPVDPTDWGGRTSPRRSAFPFPITLQEPRSQTQSLNTPGPTLSHPRATSRPINLGPSSPNTEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RILGVGRSSASSLNN CEECCCCCCHHHHCC	25.07	25293948
11	Phosphorylation	ILGVGRSSASSLNNK EECCCCCCHHHHCCC	30.70	25293948
13	Phosphorylation	GVGRSSASSLNNKED CCCCCCHHHHCCCCC	36.99	25293948
14	Phosphorylation	VGRSSASSLNNKEDN CCCCCHHHHCCCCCC	34.53	25293948
29	Phosphorylation	ESDVALLSPKDPNRV CCCCEECCCCCCCCC	30.65	25521595
129	Phosphorylation	PDPAWYQTWPGPGSR CCCHHHHCCCCCCCC	20.24	22817900
140	Phosphorylation	PGSRPSMSPKPPASQ CCCCCCCCCCCCHHH	33.82	21183079
191	Phosphorylation	APRSSVDSPRDWYRR CCCCCCCCHHHHHHH	21.49	26643407
229	Phosphorylation	VVSARASSAEPRHLG EEEEECCCCCCCCCC	35.35	18779572
237	Phosphorylation	AEPRHLGTLQRPASR CCCCCCCCCCCCCCC	26.52	24719451
243	Phosphorylation	GTLQRPASRPGTTET CCCCCCCCCCCCCCC	41.51	29472430
247	Phosphorylation	RPASRPGTTETSSGR CCCCCCCCCCCCCCC	24.92	29472430
248	Phosphorylation	PASRPGTTETSSGRN CCCCCCCCCCCCCCC	43.09	29472430
250	Phosphorylation	SRPGTTETSSGRNWN CCCCCCCCCCCCCCC	26.54	29472430
353	Phosphorylation	KDLRAIETRLPSPKN HHHHHHHHCCCCCCC	31.24	23984901
357	Phosphorylation	AIETRLPSPKNSQAP HHHHCCCCCCCCCCC	53.77	18779572
378	Phosphorylation	PGLEQQPSARLSSAW CCCCCCCCCCHHCCC	22.98	29514104
382	Phosphorylation	QQPSARLSSAWRPNS CCCCCCHHCCCCCCC	16.68	26643407
383	Phosphorylation	QPSARLSSAWRPNSP CCCCCHHCCCCCCCC	36.12	26643407
389	Phosphorylation	SSAWRPNSPHAPYFS HCCCCCCCCCCCCCC	22.27	27742792
394	Phosphorylation	PNSPHAPYFSSSRPL CCCCCCCCCCCCCCC	19.51	26643407
396	Phosphorylation	SPHAPYFSSSRPLSP CCCCCCCCCCCCCCC	22.89	26160508
397	Phosphorylation	PHAPYFSSSRPLSPH CCCCCCCCCCCCCCC	22.07	26160508
398	Phosphorylation	HAPYFSSSRPLSPHR CCCCCCCCCCCCCCC	36.40	26160508
402	Phosphorylation	FSSSRPLSPHRMADG CCCCCCCCCCCCCCC	22.73	27742792
406	Oxidation	RPLSPHRMADGGGSP CCCCCCCCCCCCCCC	3.47	17242355
412	Phosphorylation	RMADGGGSPFLGRRD CCCCCCCCCCCCCCC	18.76	25521595
425	Phosphorylation	RDFVYPSSAREPSAS CCCCCCCCCCCCCHH	27.17	25338131
436	Phosphorylation	PSASERGSSPSRKEE CCHHHCCCCCCHHHH	45.34	24719451
437	Phosphorylation	SASERGSSPSRKEEK CHHHCCCCCCHHHHH	29.71	30352176
439	Phosphorylation	SERGSSPSRKEEKKR HHCCCCCCHHHHHHH	58.91	23608596
459	Phosphorylation	KFDFQAQSPKELSLQ CCCCCCCCCCHHCCC	40.74	26824392
472	Phosphorylation	LQKGDIVYIHKEVDK CCCCCEEEEEEECCC	9.53	29514104
594	Phosphorylation	DGPQLPASPNPTTTA CCCCCCCCCCCCCCC	24.22	26824392
598	Phosphorylation	LPASPNPTTTAHLSS CCCCCCCCCCCCCCC	43.34	25777480
599	Phosphorylation	PASPNPTTTAHLSSH CCCCCCCCCCCCCCC	24.20	25777480
600	Phosphorylation	ASPNPTTTAHLSSHS CCCCCCCCCCCCCCC	17.98	25777480
604	Phosphorylation	PTTTAHLSSHSHPSS CCCCCCCCCCCCCCC	19.01	25777480
605	Phosphorylation	TTTAHLSSHSHPSSI CCCCCCCCCCCCCCC	35.06	25777480
607	Phosphorylation	TAHLSSHSHPSSIPV CCCCCCCCCCCCCCC	38.76	21659605
610	Phosphorylation	LSSHSHPSSIPVDPT CCCCCCCCCCCCCCC	35.16	23649490
611	Phosphorylation	SSHSHPSSIPVDPTD CCCCCCCCCCCCCCC	35.05	23649490
617	Phosphorylation	SSIPVDPTDWGGRTS CCCCCCCCCCCCCCC	39.66	25777480
623	Phosphorylation	PTDWGGRTSPRRSAF CCCCCCCCCCCCCCC	46.48	23567750
624	Phosphorylation	TDWGGRTSPRRSAFP CCCCCCCCCCCCCCC	18.30	21183079
628	Phosphorylation	GRTSPRRSAFPFPIT CCCCCCCCCCCCCEE	35.23	22817900
641	Phosphorylation	ITLQEPRSQTQSLNT EECCCCHHHCCCCCC	48.58	29472430
643	Phosphorylation	LQEPRSQTQSLNTPG CCCCHHHCCCCCCCC	22.75	29472430
645	Phosphorylation	EPRSQTQSLNTPGPT CCHHHCCCCCCCCCC	27.29	29472430
648	Phosphorylation	SQTQSLNTPGPTLSH HHCCCCCCCCCCCCC	34.61	22028470
652	Phosphorylation	SLNTPGPTLSHPRAT CCCCCCCCCCCCCCC	46.97	29472430
654	Phosphorylation	NTPGPTLSHPRATSR CCCCCCCCCCCCCCC	33.64	29472430
659	Phosphorylation	TLSHPRATSRPINLG CCCCCCCCCCCCCCC	26.92	26643407
660	Phosphorylation	LSHPRATSRPINLGP CCCCCCCCCCCCCCC	34.77	26643407
668	Phosphorylation	RPINLGPSSPNTEIH CCCCCCCCCCCCCEE	57.54	21659605
669	Phosphorylation	PINLGPSSPNTEIHW CCCCCCCCCCCCEEC	25.88	26824392
672	Phosphorylation	LGPSSPNTEIHWTPY CCCCCCCCCEECCCC	39.43	23737553
677	Phosphorylation	PNTEIHWTPYRAMYQ CCCCEECCCCHHHEE	9.04	23984901
679	Phosphorylation	TEIHWTPYRAMYQYR CCEECCCCHHHEEEC	12.02	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
127	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS
594	S	Phosphorylation	Kinase	MK01	P63085	PhosphoELM
648	T	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
594	S	Phosphorylation		15184391
Phosphorylated at Ser-594 by MAPK1/ERK2 during cell spreading.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VINEX_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RAF1_MOUSE	Raf1	physical	15836771

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VINEX_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Extracellular signal-regulated kinase activated by epidermal growthfactor and cell adhesion interacts with and phosphorylates vinexin."; Mitsushima M., Suwa A., Amachi T., Ueda K., Kioka N.; J. Biol. Chem. 279:34570-34577(2004). Cited for: PHOSPHORYLATION AT SER-594, INTERACTION WITH MAPK1/ERK2, ANDSUBCELLULAR LOCATION.	15184391 [Abstract]

show