SOCS6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOCS6_MOUSE
• UniProt AC: Q9JLY0
• Protein Name: Suppressor of cytokine signaling 6
• Gene Name: Socs6
• Organism: Mus musculus (Mouse).
• Sequence Length: 533
• Protein Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity)..
• Protein Sequence: MKKISLKTFRKSFNLSKSKDETEFMVVQPQSLAGDFVKDDSLFGSCYGKDMASCDIGSEDEKGKNRSKSESLMGTLKRRLSAKQKTKGKGGTASTDEDTFSSASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLRPTSSEETCIKMEMRVKALVHAASPGPVNGVRKDLRELQPRELRDLQPEPRPESRCSPSSPGDLSLHLEEHVPVVIGLMSQDYLQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGASGAFSEDDSHVDQDLVVGPEILVDSSVNNLLIGTTGVMLQSPRGGHDDAPPLSPLLPPMQNNPIQRNFSGLSGPDLHMAESVRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SLKTFRKSFNLSKSK CHHHHHHHCCCCCCC	18.34	21743459
18	Phosphorylation	KSFNLSKSKDETEFM HHCCCCCCCCCCEEE	41.80	26643407
22	Phosphorylation	LSKSKDETEFMVVQP CCCCCCCCEEEEECC	44.66	26643407
58	Phosphorylation	MASCDIGSEDEKGKN HHCCCCCCCCCCCCC	42.06	29514104
67	Phosphorylation	DEKGKNRSKSESLMG CCCCCCCCHHHHHHH	50.34	25266776
69	Phosphorylation	KGKNRSKSESLMGTL CCCCCCHHHHHHHHH	33.39	25338131
75	Phosphorylation	KSESLMGTLKRRLSA HHHHHHHHHHHHHHH	18.36	28576409
94	Phosphorylation	KGKGGTASTDEDTFS CCCCCCCCCCCCCCC	35.91	25338131
95	Phosphorylation	GKGGTASTDEDTFSS CCCCCCCCCCCCCCC	40.73	25338131
128	Phosphorylation	TSLRSHHYSPTPWPL CCCCCCCCCCCCCCC	15.77	29514104
159	Phosphorylation	KALVHAASPGPVNGV HHHHHHCCCCCCCCH	31.04	27087446
189	Phosphorylation	QPEPRPESRCSPSSP CCCCCCCCCCCCCCC	41.07	26824392
309	Phosphorylation	HDDAPPLSPLLPPMQ CCCCCCCCCCCCCCC	21.19	25619855
325	Phosphorylation	NPIQRNFSGLSGPDL CCCCCCCCCCCCCCC	42.23	19060867
328	Phosphorylation	QRNFSGLSGPDLHMA CCCCCCCCCCCCCHH	52.37	29472430
356	Phosphorylation	APGVARVYDSVQSSG CCCCEEHHHHHHCCC	9.28	29514104
403	Phosphorylation	LANVPDGSFLVRDSS CCCCCCCCEEEEECC	23.84	29176673
417	Phosphorylation	SDDRYLLSLSFRSHG CCCCEEEEEEECCCC	21.26	26370283
419	Phosphorylation	DRYLLSLSFRSHGKT CCEEEEEEECCCCCE	18.42	26370283
527	Phosphorylation	LPNKMKDYLQEKHY- CCHHHHHHHHHHCC-	12.55	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOCS6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOCS6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOCS6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOIL1_HUMAN	RBCK1	physical	16643902
ELOC_HUMAN	TCEB1	physical	19385048
ELOB_HUMAN	TCEB2	physical	19385048
KIT_MOUSE	Kit	physical	14707129
FLT3_MOUSE	Flt3	physical	22952242
BCAR1_MOUSE	Bcar1	physical	24284072

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.