FLT3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLT3_MOUSE
• UniProt AC: Q00342
• Protein Name: Receptor-type tyrosine-protein kinase FLT3
• Gene Name: Flt3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1000
• Subcellular Localization: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an im
• Protein Description: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways..
• Protein Sequence: MRALAQRSDRRLLLLVVLSVMILETVTNQDLPVIKCVLISHENNGSSAGKPSSYRMVRGSPEDLQCTPRRQSEGTVYEAATVEVAESGSITLQVQLATPGDLSCLWVFKHSSLGCQPHFDLQNRGIVSMAILNVTETQAGEYLLHIQSEAANYTVLFTVNVRDTQLYVLRRPYFRKMENQDALLCISEGVPEPTVEWVLCSSHRESCKEEGPAVVRKEEKVLHELFGTDIRCCARNALGRESTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPRIRCTWIFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFYAENDDAQFTKMFTLNIRKKPQVLANASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPFIQDNISFYATIGLCLPFIVVLIVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYVDFRDYEYDLKWEFPRENLEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNSIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEEAMYQNMGGNVPEHPSIYQNRRPLSREAGSEPPSPQAQVKIHRERS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MRALAQRSD ------CCHHHHHCH	38.00	-
7	Methylation	-MRALAQRSDRRLLL -CCHHHHHCHHHHHH	34.61	-
19	Phosphorylation	LLLLVVLSVMILETV HHHHHHHHHHHHHHC	9.68	-
25	Phosphorylation	LSVMILETVTNQDLP HHHHHHHHCCCCCCC	29.23	-
27	Phosphorylation	VMILETVTNQDLPVI HHHHHHCCCCCCCEE	34.28	-
44	N-linked_Glycosylation	VLISHENNGSSAGKP EEEEECCCCCCCCCC	49.06	-
133	N-linked_Glycosylation	IVSMAILNVTETQAG EEEEEEEEECCCCCC	32.33	-
152	N-linked_Glycosylation	HIQSEAANYTVLFTV EEEECCCCEEEEEEE	38.95	-
164	Phosphorylation	FTVNVRDTQLYVLRR EEEECCCCEEEEEEC	15.20	20139300
307	N-linked_Glycosylation	EMSTYSTNRTMIRIL EEECCCCCHHHHHHH	31.33	-
324	N-linked_Glycosylation	FVSSVGRNDTGYYTC HHHHCCCCCCCEEEC	45.31	-
352	N-linked_Glycosylation	ILEKGFINATSSQEE HHHHCCCCCCCCCCE	34.60	-
445	N-linked_Glycosylation	KKPQVLANASASQAS CCCEEEECCCCCHHC	30.21	-
474	N-linked_Glycosylation	KCSDKSPNCTEEIPE ECCCCCCCCCCCCCC	53.05	-
500	Phosphorylation	FGQWVSSSTLNMSEA HCEEECCCCCCCCCC	29.43	28059163
503	N-linked_Glycosylation	WVSSSTLNMSEAGKG EECCCCCCCCCCCCC	31.83	-
542	N-linked_Glycosylation	PFPFIQDNISFYATI CCCCCCCCHHHHHHH	18.54	-
573	Phosphorylation	KYKKQFRYESQLQMI HHHHHCCCHHHCEEE	22.63	-
575	Phosphorylation	KKQFRYESQLQMIQV HHHCCCHHHCEEEEE	27.53	-
590	Phosphorylation	TGPLDNEYFYVDFRD ECCCCCCEEEEECCC	13.38	21262971
592	Phosphorylation	PLDNEYFYVDFRDYE CCCCCEEEEECCCCE	9.75	22817900
600	Phosphorylation	VDFRDYEYDLKWEFP EECCCCEEEECEECC	21.98	21262971
631	Phosphorylation	RVMNATAYGISKTGV HHHEEEECCCCCCCC	15.61	-
727	Phosphorylation	KEHNFSFYPTFQAHS HHCCCCCCCEEECCC	12.70	-
729	Phosphorylation	HNFSFYPTFQAHSNS CCCCCCCEEECCCCC	21.83	-
760	Phosphorylation	LSGFNGNSIHSEDEI CCCCCCCCCCCHHHH	24.07	-
769	Phosphorylation	HSEDEIEYENQKRLA CCHHHHHHHHHHHHH	26.33	-
796	Phosphorylation	EDLLCFAYQVAKGME HHHHHHHHHHHCCCC	5.35	-
831	Glutathionylation	HGKVVKICDFGLARD CCCEEEECCCCCCHH	2.69	24333276
845	Phosphorylation	DILSDSSYVVRGNAR HHHCCCCEEEECCCC	13.60	22817900
868	Phosphorylation	ESLFEGIYTIKSDVW HHHHCCEEEECHHHH	17.17	-
892	Phosphorylation	FSLGVNPYPGIPVDA HHCCCCCCCCCCCCH	14.64	22817900
922	Phosphorylation	FYATEGIYFVMQSCW EEECCCEEEEEEHHH	10.85	22817900
927	Phosphorylation	GIYFVMQSCWAFDSR CEEEEEEHHHHCCCC	8.11	-
958	Phosphorylation	AEAEEAMYQNMGGNV HHHHHHHHHHCCCCC	7.49	-
972	Phosphorylation	VPEHPSIYQNRRPLS CCCCHHHHCCCCCCC	44.95	-
984	Phosphorylation	PLSREAGSEPPSPQA CCCCCCCCCCCCHHH	35.29	22817900
988	Phosphorylation	EAGSEPPSPQAQVKI CCCCCCCCHHHCCEE	21.60	22817900
1000	Phosphorylation	VKIHRERS------- CEEECCCC-------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
592	Y	Phosphorylation	Kinase	FLT3	Q00342	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FLT3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLT3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOCS6_MOUSE	Socs6	physical	22952242
SOCS2_MOUSE	Socs2	physical	23548639

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.