TLR7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLR7_HUMAN
• UniProt AC: Q9NYK1
• Protein Name: Toll-like receptor 7
• Gene Name: TLR7
• Organism: Homo sapiens (Human).
• Sequence Length: 1049
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome . Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
• Protein Description: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)..
• Protein Sequence: MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LFNIILISKLLGARW HHHHHHHHHHHCCCC	17.51	29396449
66	N-linked_Glycosylation	IPGGIPTNTTNLTLT CCCCCCCCCCCEEEE	39.28	UniProtKB CARBOHYD
69	N-linked_Glycosylation	GIPTNTTNLTLTINH CCCCCCCCEEEEEEC	29.05	UniProtKB CARBOHYD
167	N-linked_Glycosylation	IFSIRKENLTELANI CEEEECCCHHHHHCE	56.13	UniProtKB CARBOHYD
202	N-linked_Glycosylation	IEKDAFLNLTKLKVL ECCCCEECCCEEEEE	38.93	UniProtKB CARBOHYD
210	Phosphorylation	LTKLKVLSLKDNNVT CCEEEEEECCCCCCC	36.04	24719451
215	N-linked_Glycosylation	VLSLKDNNVTAVPTV EEECCCCCCCCCCCC	42.52	UniProtKB CARBOHYD
293	Ubiquitination	FDALTELKVLRLHSN HHHHHHHHHHHHCCC	32.75	-
359	Phosphorylation	ELQVYRASMNLSQAF EEHHHHHHCCHHHHH	10.13	-
361	N-linked_Glycosylation	QVYRASMNLSQAFSS HHHHHHCCHHHHHHH	33.76	UniProtKB CARBOHYD
371	Phosphorylation	QAFSSLKSLKILRIR HHHHHCHHCCHHEEE	39.94	-
413	N-linked_Glycosylation	TNFIKIANLSMFKQF CCHHHHHCHHHHHHH	35.80	UniProtKB CARBOHYD
488	N-linked_Glycosylation	EASFMSVNESCYKYG CCCCEEECHHHHHCC	28.32	UniProtKB CARBOHYD
517	Phosphorylation	SSDFQHLSFLKCLNL CCCCCHHHHHHHCCC	26.80	24719451
523	N-linked_Glycosylation	LSFLKCLNLSGNLIS HHHHHHCCCCCCEEE	41.45	UniProtKB CARBOHYD
534	N-linked_Glycosylation	NLISQTLNGSEFQPL CEEEEECCCCCCCCC	56.16	UniProtKB CARBOHYD
590	N-linked_Glycosylation	EGITHMLNFTKNLKV CCHHHHHHHHHHHHH	34.66	UniProtKB CARBOHYD
609	Phosphorylation	MMNDNDISSSTSRTM HCCCCCCCCCCCHHH	22.54	-
610	Phosphorylation	MNDNDISSSTSRTME CCCCCCCCCCCHHHH	37.66	-
679	N-linked_Glycosylation	GMPPNLKNLSLAKNG CCCCCHHHHHHHHCC	37.72	UniProtKB CARBOHYD
684	Acetylation	LKNLSLAKNGLKSFS HHHHHHHHCCCCCCC	57.76	25953088
720	N-linked_Glycosylation	TVPERLSNCSRSLKN CHHHHHHCCCHHHHH	32.16	UniProtKB CARBOHYD
722	Phosphorylation	PERLSNCSRSLKNLI HHHHHCCCHHHHHHH	29.20	-
724	Phosphorylation	RLSNCSRSLKNLILK HHHCCCHHHHHHHHH	27.66	-
799	N-linked_Glycosylation	VWFVWWVNHTEVTIP EEEEEECCCCCCCCC	23.73	UniProtKB CARBOHYD
807	Phosphorylation	HTEVTIPYLATDVTC CCCCCCCEEEECEEE	12.72	-
958	Phosphorylation	KKTVFVMTDKYAKTE CCEEEEECCCCCCCC	24.84	29083192
1041	Phosphorylation	ATDNHVAYSQVFKET HCCCCHHHHHHHHHC	9.88	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLR7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLR7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLR7_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TLR7_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.