| UniProt ID | IRAK2_HUMAN | |
|---|---|---|
| UniProt AC | O43187 | |
| Protein Name | Interleukin-1 receptor-associated kinase-like 2 | |
| Gene Name | IRAK2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 625 | |
| Subcellular Localization | ||
| Protein Description | Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.. | |
| Protein Sequence | MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIELFGP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MACYIYQLPSW ----CCCEEEECCHH | 7.98 | - | |
| 6 | Phosphorylation | --MACYIYQLPSWVL --CCCEEEECCHHHH | 4.22 | - | |
| 137 | Phosphorylation | GQPVRMATFPGPGSS CCCEEEEECCCCCCC | 22.48 | 29396449 | |
| 143 | Phosphorylation | ATFPGPGSSPARAHQ EECCCCCCCCHHHCC | 35.96 | 25159151 | |
| 144 | Phosphorylation | TFPGPGSSPARAHQP ECCCCCCCCHHHCCC | 28.61 | 25159151 | |
| 164 | Phosphorylation | PEEDAPHSLRSDLPT CCCCCCCCHHCCCCC | 25.15 | 28555341 | |
| 176 | Ubiquitination | LPTSSDSKDFSTSIP CCCCCCCCCCCCCCC | 68.71 | 29967540 | |
| 179 | Phosphorylation | SSDSKDFSTSIPKQE CCCCCCCCCCCCHHH | 31.23 | 23612710 | |
| 181 | Phosphorylation | DSKDFSTSIPKQEKL CCCCCCCCCCHHHHH | 35.38 | 24719451 | |
| 184 | Ubiquitination | DFSTSIPKQEKLLSL CCCCCCCHHHHHHHH | 70.22 | 29967540 | |
| 190 | Phosphorylation | PKQEKLLSLAGDSLF CHHHHHHHHHCCCCC | 26.98 | 30377224 | |
| 195 | Phosphorylation | LLSLAGDSLFWSEAD HHHHHCCCCCCCHHH | 25.25 | 30377224 | |
| 199 | Phosphorylation | AGDSLFWSEADVVQA HCCCCCCCHHHEEEE | 18.64 | 30377224 | |
| 215 | Ubiquitination | DDFNQNRKISQGTFA CCCCCCCCCCCCCHH | 55.01 | 29967540 | |
| 246 | Phosphorylation | LRETACSSPGSIERF HHHHHCCCCCHHHHH | 32.91 | 21815630 | |
| 350 | Ubiquitination | LDQNLTPKLAHPMAH ECCCCCHHHCCCHHH | 53.74 | 29967540 | |
| 363 | Ubiquitination | AHLCPVNKRSKYTMM HHHCCCCCCCCHHHH | 59.28 | 29967540 | |
| 372 | Phosphorylation | SKYTMMKTHLLRTSA CCHHHHHHHHHHHHH | 10.40 | 22210691 | |
| 378 | Phosphorylation | KTHLLRTSAAYLPED HHHHHHHHHHHCCHH | 12.41 | 22210691 | |
| 381 | Phosphorylation | LLRTSAAYLPEDFIR HHHHHHHHCCHHHHH | 23.62 | 22210691 | |
| 393 | Phosphorylation | FIRVGQLTKRVDIFS HHHHCCCCCCEEEEC | 14.66 | 22210691 | |
| 425 | Ubiquitination | NRSPVYLKDLLLSDI CCCCCCHHHHHHCCC | 28.74 | 21987572 | |
| 430 | Phosphorylation | YLKDLLLSDIPSSTA CHHHHHHCCCCCCHH | 33.20 | - | |
| 434 | Phosphorylation | LLLSDIPSSTASLCS HHHCCCCCCHHHHHC | 40.43 | - | |
| 438 | Phosphorylation | DIPSSTASLCSRKTG CCCCCHHHHHCCCCC | 29.96 | - | |
| 443 | Ubiquitination | TASLCSRKTGVENVM HHHHHCCCCCCHHHH | 33.08 | 29967540 | |
| 452 | Ubiquitination | GVENVMAKEICQKYL CCHHHHHHHHHHHHH | 29.53 | 29967540 | |
| 457 | Ubiquitination | MAKEICQKYLEKGAG HHHHHHHHHHHCCCC | 47.60 | 29967540 | |
| 461 | Acetylation | ICQKYLEKGAGRLPE HHHHHHHCCCCCCCH | 52.01 | 7481253 | |
| 619 | Phosphorylation | YKEEKVDSIELFGP- HHHHHCCCEEECCC- | 22.43 | 28102081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IRAK2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IRAK2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IRAK2_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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