dbPTM

ZC12C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZC12C_HUMAN
UniProt AC	Q9C0D7
Protein Name	Probable ribonuclease ZC3H12C
Gene Name	ZC3H12C
Organism	Homo sapiens (Human).
Sequence Length	883
Subcellular Localization
Protein Description	May function as RNase and regulate the levels of target RNA species..
Protein Sequence	MPGGGSQEYGVLCIQEYRKNSKVESSTRNNFMGLKDHLGHDLGHLYVESTDPQLSPAVPWSTVENPSMDTVNVGKDEKEASEENASSGDSEENTNSDHESEQLGSISVEPGLITKTHRQLCRSPCLEPHILKRNEILQDFKPEESQTTSKEAKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTINTITRETSSLESQRSESPMQEIVTDDGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAAKTANEGGLVKSNSVPCSTKADSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPSMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSLSGPRSPERRFSLDTDYRISSVASDCSSEGSMSCGSSDSYVGYNDRSYVSSPDPQLEENLKCQHMHPHSRLNPQPFLQNFHDPLTRGQSYSHEEPKFHHKPPLPHLALHLPHSAVGARSSCPGDYPSPPSSAHSKAPHLGRSLVATRIDSISDSRLYDSSPSRQRKPYSRQEGLGSWERPGYGIDAYGYRQTYSLPDNSTQPCYEQFTFQSLPEQQEPAWRIPYCGMPQDPPRYQDNREKIYINLCNIFPPDLVRIVMKRNPHMTDAQQLAAAILVEKSQLGY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	EASEENASSGDSEEN HHHHHHHCCCCCCCC	46.57	26471730
87	Phosphorylation	ASEENASSGDSEENT HHHHHHCCCCCCCCC	44.18	26471730
90	Phosphorylation	ENASSGDSEENTNSD HHHCCCCCCCCCCCC	50.78	26471730
94	Phosphorylation	SGDSEENTNSDHESE CCCCCCCCCCCCCHH	39.10	26471730
96	Phosphorylation	DSEENTNSDHESEQL CCCCCCCCCCCHHHH	38.00	26471730
100	Phosphorylation	NTNSDHESEQLGSIS CCCCCCCHHHHCCCE	27.50	26471730
105	Phosphorylation	HESEQLGSISVEPGL CCHHHHCCCEECCCC	21.93	30576142
107	Phosphorylation	SEQLGSISVEPGLIT HHHHCCCEECCCCCH	23.33	26471730
123	Phosphorylation	THRQLCRSPCLEPHI HHHHHCCCCCCCHHH	20.97	25159151
162	Phosphorylation	PPDVVREYQTKLEFA CCHHHHHHHHHHHHH	15.77	18083107
222	Phosphorylation	INTITRETSSLESQR HHHHHHHCHHHHHCC	21.96	-
223	Phosphorylation	NTITRETSSLESQRS HHHHHHCHHHHHCCC	28.33	-
224	Phosphorylation	TITRETSSLESQRSE HHHHHCHHHHHCCCC	43.50	-
227	Phosphorylation	RETSSLESQRSESPM HHCHHHHHCCCCCCC	35.87	-
230	Phosphorylation	SSLESQRSESPMQEI HHHHHCCCCCCCCEE	34.49	18669648
232	Phosphorylation	LESQRSESPMQEIVT HHHCCCCCCCCEEEC	27.24	25849741
239	Phosphorylation	SPMQEIVTDDGENLR CCCCEEECCCCCCEE	33.75	27080861
253	Phosphorylation	RPIVIDGSNVAMSHG EEEEEECCCEECCCC	25.12	27080861
321	Phosphorylation	KEKILVFTPSRRVQG HCCEEEECCCCCCCC	16.93	21815630
418	Phosphorylation	HKKQPCPYGKKCTYG CCCCCCCCCCCCCCC	48.58	-
442	Phosphorylation	RGSQPQRSVADELRA CCCCCCHHHHHHHHH	19.19	22210691
458	Phosphorylation	SRNTAAKTANEGGLV HHHHHCCHHCCCCCC	29.95	28258704
467	Phosphorylation	NEGGLVKSNSVPCST CCCCCCCCCCCCCCC	27.19	29514088
469	Phosphorylation	GGLVKSNSVPCSTKA CCCCCCCCCCCCCCC	34.23	28985074
473	Phosphorylation	KSNSVPCSTKADSTS CCCCCCCCCCCCCCC	27.20	28102081
474	Phosphorylation	SNSVPCSTKADSTSD CCCCCCCCCCCCCCC	36.65	28102081
478	Phosphorylation	PCSTKADSTSDVKRG CCCCCCCCCCCCCCC	34.37	-
491	Phosphorylation	RGAPKRQSDPSIRTQ CCCCCCCCCHHHHHH	56.36	25056879
494	Phosphorylation	PKRQSDPSIRTQVYQ CCCCCCHHHHHHHHH	29.68	28102081
515	Phosphorylation	PTKNKLETRSVPSLV CCCCCCCCCCCCCEE	38.39	29514088
517	Phosphorylation	KNKLETRSVPSLVSI CCCCCCCCCCCEEEC	45.88	29743597
520	Phosphorylation	LETRSVPSLVSIPAT CCCCCCCCEEECCCC	38.97	22199227
523	Phosphorylation	RSVPSLVSIPATSTA CCCCCEEECCCCCCC	28.31	29514088
528	O-linked_Glycosylation	LVSIPATSTAKPQST EEECCCCCCCCCCCC	28.59	28657654
596	Phosphorylation	YYSMLNAYSNLSLSG HHHHHHHHHCCCCCC	9.30	-
602	Phosphorylation	AYSNLSLSGPRSPER HHHCCCCCCCCCHHC	43.29	23312004
612	Phosphorylation	RSPERRFSLDTDYRI CCHHCCEECCCCCCH	24.43	30266825
615	Phosphorylation	ERRFSLDTDYRISSV HCCEECCCCCCHHHH	39.98	23403867
617	Phosphorylation	RFSLDTDYRISSVAS CEECCCCCCHHHHHC	16.37	23403867
637	Phosphorylation	GSMSCGSSDSYVGYN CCCCCCCCCCCCCCC	18.83	30576142
639	Phosphorylation	MSCGSSDSYVGYNDR CCCCCCCCCCCCCCC	24.54	30576142
643	Phosphorylation	SSDSYVGYNDRSYVS CCCCCCCCCCCCCCC	12.12	30576142
647	Phosphorylation	YVGYNDRSYVSSPDP CCCCCCCCCCCCCCH	32.52	23403867
648	Phosphorylation	VGYNDRSYVSSPDPQ CCCCCCCCCCCCCHH	12.78	23403867
650	Phosphorylation	YNDRSYVSSPDPQLE CCCCCCCCCCCHHHH	28.11	23403867
651	Phosphorylation	NDRSYVSSPDPQLEE CCCCCCCCCCHHHHH	24.23	23927012
689	Phosphorylation	DPLTRGQSYSHEEPK CCCCCCCCCCCCCCC	31.28	29743597
690	Phosphorylation	PLTRGQSYSHEEPKF CCCCCCCCCCCCCCC	13.22	26852163
691	Phosphorylation	LTRGQSYSHEEPKFH CCCCCCCCCCCCCCC	29.66	28985074
719	Phosphorylation	HSAVGARSSCPGDYP CCCCCCCCCCCCCCC	35.44	27251275
720	Phosphorylation	SAVGARSSCPGDYPS CCCCCCCCCCCCCCC	20.83	28985074
742	Phosphorylation	KAPHLGRSLVATRID CCCCCCCCHHHHEEC	25.95	28509920
746	Phosphorylation	LGRSLVATRIDSISD CCCCHHHHEECCCCC	22.22	28509920
750	Phosphorylation	LVATRIDSISDSRLY HHHHEECCCCCCCCC	22.94	23927012
752	Phosphorylation	ATRIDSISDSRLYDS HHEECCCCCCCCCCC	33.22	21815630
754	Phosphorylation	RIDSISDSRLYDSSP EECCCCCCCCCCCCC	19.86	27251275
757	Phosphorylation	SISDSRLYDSSPSRQ CCCCCCCCCCCCCCC	16.81	25072903
759	Phosphorylation	SDSRLYDSSPSRQRK CCCCCCCCCCCCCCC	30.50	29255136
760	Phosphorylation	DSRLYDSSPSRQRKP CCCCCCCCCCCCCCC	24.81	29255136
762	Phosphorylation	RLYDSSPSRQRKPYS CCCCCCCCCCCCCCC	42.89	25072903
768	Phosphorylation	PSRQRKPYSRQEGLG CCCCCCCCCCCCCCC	21.37	22210691
776	Phosphorylation	SRQEGLGSWERPGYG CCCCCCCCCCCCCCC	30.70	23927012
782	Phosphorylation	GSWERPGYGIDAYGY CCCCCCCCCCCCCCE	17.37	22210691
811	Phosphorylation	YEQFTFQSLPEQQEP CHHCCCCCCCCCCCC	41.52	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZC12C_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZC12C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZC12C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZC12C_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZC12C_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, AND MASSSPECTROMETRY.	18669648 [Abstract]