PELI3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PELI3_HUMAN
• UniProt AC: Q8N2H9
• Protein Name: E3 ubiquitin-protein ligase pellino homolog 3
• Gene Name: PELI3
• Organism: Homo sapiens (Human).
• Sequence Length: 469
• Protein Description: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation..
• Protein Sequence: MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGCCEEGGEETEAQRGEVTGPRAHSCYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	EGNPEVGSPRTSDLQ CCCCCCCCCCHHHCC	19.18	25850435
85	Ubiquitination	GCLASGDKGRRRSRL CCHHCCCCCHHHHHH	58.82	-
95	Phosphorylation	RRSRLALSRRSHANG HHHHHHHHHHHHHCC	21.75	24719451
98	Phosphorylation	RLALSRRSHANGVKP HHHHHHHHHHCCCCC	26.33	29978859
112	Phosphorylation	PDVMHHISTPLVSKA CCHHHHCCHHHHHHH	21.44	29978859
113	Phosphorylation	DVMHHISTPLVSKAL CHHHHCCHHHHHHHH	21.75	29978859
117	Phosphorylation	HISTPLVSKALSNRG HCCHHHHHHHHHCCC	21.64	29978859
121	Phosphorylation	PLVSKALSNRGQHSI HHHHHHHHCCCCCEE	29.37	29083192
127	Phosphorylation	LSNRGQHSISYTLSR HHCCCCCEEEEEECC	12.82	30576142
129	Phosphorylation	NRGQHSISYTLSRSH CCCCCEEEEEECCCC	18.32	30576142
130	Phosphorylation	RGQHSISYTLSRSHS CCCCEEEEEECCCCE	15.27	-
131	Phosphorylation	GQHSISYTLSRSHSV CCCEEEEEECCCCEE	16.09	30576142
133	Phosphorylation	HSISYTLSRSHSVIV CEEEEEECCCCEEEE	24.76	-
135	Phosphorylation	ISYTLSRSHSVIVEY EEEEECCCCEEEEEE	19.42	25072903
137	Phosphorylation	YTLSRSHSVIVEYTH EEECCCCEEEEEEEC	18.13	25072903
142	Phosphorylation	SHSVIVEYTHDSDTD CCEEEEEEECCCCCC	9.85	25072903
143	Phosphorylation	HSVIVEYTHDSDTDM CEEEEEEECCCCCCC	13.00	25072903
156	Phosphorylation	DMFQIGRSTENMIDF CCEEECCCCCCCEEE	34.56	24043423
157	Phosphorylation	MFQIGRSTENMIDFV CEEECCCCCCCEEEE	29.98	24043423
166	Phosphorylation	NMIDFVVTDTSPGGG CCEEEEEEECCCCCC	28.40	24043423
168	Phosphorylation	IDFVVTDTSPGGGAA EEEEEEECCCCCCCC	27.70	24043423
169	Phosphorylation	DFVVTDTSPGGGAAE EEEEEECCCCCCCCC	25.10	24043423
179	Phosphorylation	GGAAEGPSAQSTISR CCCCCCCCHHHHHHH	50.20	24043423
182	Phosphorylation	AEGPSAQSTISRYAC CCCCCHHHHHHHHHH	27.68	24043423
183	Phosphorylation	EGPSAQSTISRYACR CCCCHHHHHHHHHHH	15.76	24043423
185	Phosphorylation	PSAQSTISRYACRIL CCHHHHHHHHHHHHH	21.23	24043423
267	Phosphorylation	SVCGNVYTLRDSRSA EEECCEEEEECCHHH	15.84	24719451
305	Phosphorylation	GATLLWRTPAGLLRA CCEEEECCCCHHHHC	13.10	24888630
316	Ubiquitination	LLRAPTLKQLEAQRQ HHHCCHHHHHHHHHH	56.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PELI3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PELI3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PELI3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRAK1_HUMAN	IRAK1	physical	18326498
TRAF6_HUMAN	TRAF6	physical	18326498
M3K7_HUMAN	MAP3K7	physical	18326498
IRAK1_HUMAN	IRAK1	physical	17675297
IRAK1_HUMAN	IRAK1	physical	12874243
TRAF6_HUMAN	TRAF6	physical	12874243
M3K7_HUMAN	MAP3K7	physical	12874243
M3K14_HUMAN	MAP3K14	physical	12874243
TRAF6_HUMAN	TRAF6	physical	15917247
M3K7_HUMAN	MAP3K7	physical	15917247
IRAK1_HUMAN	IRAK1	physical	15917247
TRAF6_HUMAN	TRAF6	physical	23042151
A4_HUMAN	APP	physical	21832049
RIPK2_HUMAN	RIPK2	physical	23892723
UBE2N_HUMAN	UBE2N	physical	23892723
UB2V1_HUMAN	UBE2V1	physical	23892723
IRAK1_HUMAN	IRAK1	physical	25027698
UCRI_HUMAN	UQCRFS1	physical	25027698
TRAF6_HUMAN	TRAF6	physical	25027698
KANK2_HUMAN	KANK2	physical	26186194
CHIP_HUMAN	STUB1	physical	26186194
DNJB4_HUMAN	DNAJB4	physical	26186194
P55G_HUMAN	PIK3R3	physical	25814554

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.