WDR61_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR61_HUMAN
• UniProt AC: Q9GZS3
• Protein Name: WD repeat-containing protein 61
• Gene Name: WDR61
• Organism: Homo sapiens (Human).
• Sequence Length: 305
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C..
• Protein Sequence: MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTNQYGIL -------CCCCCEEE	7.77	22223895
2	Acetylation	------MTNQYGILF ------CCCCCEEEE	30.91	22223895
2	Phosphorylation	------MTNQYGILF ------CCCCCEEEE	30.91	20068231
5	Phosphorylation	---MTNQYGILFKQE ---CCCCCEEEEECC	14.27	20068231
10	Sumoylation	NQYGILFKQEQAHDD CCCEEEEECCCCCCC	49.86	-
28	Ubiquitination	SVAWGTNKKENSETV EEEECCCCCCCCEEE	62.39	-
29	Ubiquitination	VAWGTNKKENSETVV EEECCCCCCCCEEEE	65.28	21906983
32	Phosphorylation	GTNKKENSETVVTGS CCCCCCCCEEEEEEC	35.42	21406692
34	Phosphorylation	NKKENSETVVTGSLD CCCCCCEEEEEECHH	21.79	21406692
37	Phosphorylation	ENSETVVTGSLDDLV CCCEEEEEECHHHHH	19.40	21406692
39	Phosphorylation	SETVVTGSLDDLVKV CEEEEEECHHHHHHH	21.18	21406692
45	Ubiquitination	GSLDDLVKVWKWRDE ECHHHHHHHEEECCC	50.07	-
97	Ubiquitination	LWDLENGKQIKSIDA EEECCCCCEEEEECC	61.50	21906983
100	Ubiquitination	LENGKQIKSIDAGPV CCCCCEEEEECCCCC	38.57	-
139	Acetylation	IFGVESGKKEYSLDT EEEECCCCEEEEECC	52.27	25953088
139	Ubiquitination	IFGVESGKKEYSLDT EEEECCCCEEEEECC	52.27	21906983
140	Ubiquitination	FGVESGKKEYSLDTR EEECCCCEEEEECCC	66.46	-
140	2-Hydroxyisobutyrylation	FGVESGKKEYSLDTR EEECCCCEEEEECCC	66.46	-
146	Phosphorylation	KKEYSLDTRGKFILS CEEEEECCCCCEEEE	46.76	20068231
157	Phosphorylation	FILSIAYSPDGKYLA EEEEEEECCCCCEEC	13.90	26091039
257	Ubiquitination	SSSDKSVKVWDVGTR CCCCCCEEEEECCCC	44.70	-
257	Acetylation	SSSDKSVKVWDVGTR CCCCCCEEEEECCCC	44.70	25953088
301	Phosphorylation	DDQEIHIYDCPI--- CCCEEEEEECCC---	9.42	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR61_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR61_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR61_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR5_HUMAN	WDR5	physical	17041588
CTR9_HUMAN	CTR9	physical	22451921
LEO1_HUMAN	LEO1	physical	22451921
PAF1_HUMAN	PAF1	physical	22451921
CDC73_HUMAN	CDC73	physical	22451921
HXK1_HUMAN	HK1	physical	22863883
HXK2_HUMAN	HK2	physical	22863883
PLCG1_HUMAN	PLCG1	physical	22863883
PYGB_HUMAN	PYGB	physical	22863883
SYRC_HUMAN	RARS	physical	22863883
RIC8A_HUMAN	RIC8A	physical	22863883
CDC73_HUMAN	CDC73	physical	26344197
CTR9_HUMAN	CTR9	physical	26344197
DDX3X_HUMAN	DDX3X	physical	26344197
DNJC2_HUMAN	DNAJC2	physical	26344197
ERCC2_HUMAN	ERCC2	physical	26344197
BRE1B_HUMAN	RNF40	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.