UBP19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP19_HUMAN
• UniProt AC: O94966
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 19
• Gene Name: USP19
• Organism: Homo sapiens (Human).
• Sequence Length: 1318
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein .
• Protein Description: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains..
• Protein Sequence: MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKVPMLTWPSLLVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGNDPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVHVYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGGASATG ------CCCCCCCCC	58.18	19413330
2	Phosphorylation	------MSGGASATG ------CCCCCCCCC	58.18	24850871
6	Phosphorylation	--MSGGASATGPRRG --CCCCCCCCCCCCC	29.64	24850871
8	Phosphorylation	MSGGASATGPRRGPP CCCCCCCCCCCCCCC	45.27	24850871
20	Phosphorylation	GPPGLEDTTSKKKQK CCCCCCCCCCHHHHH	24.48	28555341
21	Phosphorylation	PPGLEDTTSKKKQKD CCCCCCCCCHHHHHH	51.36	-
22	Phosphorylation	PGLEDTTSKKKQKDR CCCCCCCCHHHHHHH	44.57	-
23	Acetylation	GLEDTTSKKKQKDRA CCCCCCCHHHHHHHC	62.99	68389
27	Ubiquitination	TTSKKKQKDRANQES CCCHHHHHHHCCCCC	59.05	24816145
47 (in isoform 1)	Phosphorylation	-	11.22	24719451
47	Phosphorylation	RKETGSRYVAQAGLE CHHHCCHHHHHCCCC	11.22	27080861
47 (in isoform 6)	Phosphorylation	-	11.22	27642862
58	Phosphorylation	AGLEPLASGDPSASA CCCCCCCCCCCCCCH	51.95	28555341
62	Phosphorylation	PLASGDPSASASHAA CCCCCCCCCCHHHHC	39.33	27080861
64	Phosphorylation	ASGDPSASASHAAGI CCCCCCCCHHHHCCC	34.34	28857561
66	Phosphorylation	GDPSASASHAAGITG CCCCCCHHHHCCCCC	15.91	27080861
72 (in isoform 1)	Phosphorylation	-	28.34	24719451
72	Phosphorylation	ASHAAGITGSRHRTR HHHHCCCCCCCCEEE	28.34	28857561
74	Phosphorylation	HAAGITGSRHRTRLF HHCCCCCCCCEEEEE	19.10	28857561
84	Phosphorylation	RTRLFFPSSSGSAST EEEEECCCCCCCCCC	31.79	28555341
85	Phosphorylation	TRLFFPSSSGSASTP EEEECCCCCCCCCCC	38.67	28555341
86	Phosphorylation	RLFFPSSSGSASTPQ EEECCCCCCCCCCCH	40.90	28555341
90	Phosphorylation	PSSSGSASTPQEEQT CCCCCCCCCCHHHHC	42.17	21815630
91	Phosphorylation	SSSGSASTPQEEQTK CCCCCCCCCHHHHCC	28.80	28555341
111 (in isoform 1)	Phosphorylation	-	27.88	27251275
111	Phosphorylation	DPHDLLATPTPELLL CHHHHCCCCCHHHHH	27.88	28857561
172	Phosphorylation	VFYAEIKSSCAKVQT EEEEEHHHHCEEEEE	35.99	27174698
173	Phosphorylation	FYAEIKSSCAKVQTR EEEEHHHHCEEEEEC	17.06	27174698
183 (in isoform 1)	Phosphorylation	-	30.69	27251275
183	Phosphorylation	KVQTRKGSLLHLTLP EEEECCCCEEEEECC	30.69	30108239
188	Phosphorylation	KGSLLHLTLPKKVPM CCCEEEEECCCCCCC	30.21	23312004
204	Ubiquitination	TWPSLLVEADEQLCI CCCHHEEECCHHCCC	50.82	21890473
210 (in isoform 2)	Phosphorylation	-	4.36	25159151
215 (in isoform 7)	Phosphorylation	-	37.53	25159151
225 (in isoform 1)	Phosphorylation	-	60.28	24719451
225 (in isoform 5)	Phosphorylation	-	60.28	25159151
225 (in isoform 6)	Phosphorylation	-	60.28	25159151
241 (in isoform 7)	Methylation	-	51.39	-
244	Phosphorylation	PPGNDPVSPAMVRSR CCCCCCCCHHHHHCC	16.60	30266825
250	Phosphorylation	VSPAMVRSRNPGKDD CCHHHHHCCCCCCCC	25.62	26074081
252 (in isoform 2)	Phosphorylation	-	51.42	25159151
257 (in isoform 7)	Phosphorylation	-	37.45	25159151
267 (in isoform 5)	Phosphorylation	-	10.61	25159151
267 (in isoform 6)	Phosphorylation	-	10.61	25159151
268 (in isoform 2)	Phosphorylation	-	27.31	26437602
273 (in isoform 7)	Phosphorylation	-	7.32	26437602
283 (in isoform 5)	Phosphorylation	-	11.28	26437602
283 (in isoform 6)	Phosphorylation	-	11.28	26437602
292	Acetylation	VKNDSYEKGPDSVVV EECCCCCCCCCCEEE	68.46	25953088
302	Phosphorylation	DSVVVHVYVKEICRD CCEEEEEEEHHHHCC	7.30	22461510
345 (in isoform 1)	Phosphorylation	-	22.33	27251275
393	Phosphorylation	PAARVGGAKVAVPTG CCHHCCCEEEEEECC	9.38	32142685
395	Phosphorylation	ARVGGAKVAVPTGPT HHCCCEEEEEECCCC	6.86	32142685
399	Phosphorylation	GAKVAVPTGPTPLDS CEEEEEECCCCCCCC	49.55	29978859
402	Phosphorylation	VAVPTGPTPLDSTPP EEEECCCCCCCCCCC	37.52	28450419
406	Phosphorylation	TGPTPLDSTPPGGAP CCCCCCCCCCCCCCC	50.96	23401153
407	Phosphorylation	GPTPLDSTPPGGAPH CCCCCCCCCCCCCCC	32.92	25159151
408	Phosphorylation	PTPLDSTPPGGAPHP CCCCCCCCCCCCCCC	29.50	32142685
410	Phosphorylation	PLDSTPPGGAPHPLT CCCCCCCCCCCCCCC	46.21	32142685
417	Phosphorylation	GGAPHPLTGQEEARA CCCCCCCCCHHHHHH	41.07	28450419
446	Phosphorylation	LDSVATRTPMEHVTP CCCCCCCCCCCCCCC	23.72	23879269
452	Phosphorylation	RTPMEHVTPKPETHL CCCCCCCCCCCCCCC	27.74	25159151
457	Phosphorylation	HVTPKPETHLASPKP CCCCCCCCCCCCCCC	30.62	32142685
461	Phosphorylation	KPETHLASPKPTCMV CCCCCCCCCCCEEEC	39.55	23927012
465	Phosphorylation	HLASPKPTCMVPPMP CCCCCCCEEECCCCC	21.25	27732954
474	Phosphorylation	MVPPMPHSPVSGDSV ECCCCCCCCCCCCCC	22.56	25850435
477	Phosphorylation	PMPHSPVSGDSVEEE CCCCCCCCCCCCHHH	40.02	25850435
480	Phosphorylation	HSPVSGDSVEEEEEE CCCCCCCCCHHHHHH	34.65	25159151
494	Phosphorylation	EEKKVCLPGFTGLVN HHHCCCCCCCCCCEE	30.63	32142685
496	Phosphorylation	KKVCLPGFTGLVNLG HCCCCCCCCCCEECC	4.65	32142685
497	Phosphorylation	KVCLPGFTGLVNLGN CCCCCCCCCCEECCC	35.21	32142685
506	Phosphorylation	LVNLGNTCFMNSVIQ CEECCCCHHHHHHHH	3.36	32142685
507 (in isoform 1)	Phosphorylation	-	4.96	24719451
507	Phosphorylation	VNLGNTCFMNSVIQS EECCCCHHHHHHHHH	4.96	32142685
508 (in isoform 1)	Phosphorylation	-	3.88	27251275
508	Phosphorylation	NLGNTCFMNSVIQSL ECCCCHHHHHHHHHH	3.88	32142685
509	Phosphorylation	LGNTCFMNSVIQSLS CCCCHHHHHHHHHHC	16.93	32142685
547 (in isoform 1)	Phosphorylation	-	9.86	27251275
569	Ubiquitination	HHAFQPSKLKAIVAS CCCCCHHHHHHHHHH	61.77	29967540
571	Ubiquitination	AFQPSKLKAIVASKA CCCHHHHHHHHHHCC	39.54	29967540
575 (in isoform 1)	Phosphorylation	-	10.13	27251275
610	Ubiquitination	DLNRIQNKPYTETVD HHHHHHCCCCCCEEC	24.03	21906983
610 (in isoform 1)	Ubiquitination	-	24.03	21890473
610 (in isoform 3)	Ubiquitination	-	24.03	21890473
636	Ubiquitination	EAWQRHKMRNDSFIV HHHHHHHHCCCCEEH	3.85	21890473
638	Ubiquitination	WQRHKMRNDSFIVDL HHHHHHCCCCEEHHH	45.86	21890473
640	Ubiquitination	RHKMRNDSFIVDLFQ HHHHCCCCEEHHHHC	22.03	21890473
645	Ubiquitination	NDSFIVDLFQGQYKS CCCEEHHHHCCCCCC	2.09	23000965
651	Ubiquitination	DLFQGQYKSKLVCPV HHHCCCCCCCEECCC	32.97	21906983
651 (in isoform 1)	Ubiquitination	-	32.97	21890473
651 (in isoform 3)	Ubiquitination	-	32.97	21890473
653	Acetylation	FQGQYKSKLVCPVCA HCCCCCCCEECCCCE	40.56	25953088
653	Ubiquitination	FQGQYKSKLVCPVCA HCCCCCCCEECCCCE	40.56	21890473
655	Ubiquitination	GQYKSKLVCPVCAKV CCCCCCEECCCCEEE	3.89	21890473
660	Ubiquitination	KLVCPVCAKVSITFD CEECCCCEEEEEEEC	18.60	29967540
662	Ubiquitination	VCPVCAKVSITFDPF ECCCCEEEEEEECCC	2.38	29967540
670	Ubiquitination	SITFDPFLYLPVPLP EEEECCCEECCCCCC	5.37	29967540
672	Ubiquitination	TFDPFLYLPVPLPQK EECCCEECCCCCCCC	3.61	29967540
673	Ubiquitination	FDPFLYLPVPLPQKQ ECCCEECCCCCCCCC	16.48	21890473
674	Ubiquitination	DPFLYLPVPLPQKQK CCCEECCCCCCCCCC	7.59	29967540
689	Ubiquitination	VLPVFYFAREPHSKP EEEEEEECCCCCCCC	11.98	23000965
695	Ubiquitination	FAREPHSKPIKFLVS ECCCCCCCCEEEEEE	47.96	23000965
701	Ubiquitination	SKPIKFLVSVSKENS CCCEEEEEEECCCCC	6.30	29967540
702	Ubiquitination	KPIKFLVSVSKENST CCEEEEEEECCCCCC	23.87	21890473
704	Ubiquitination	IKFLVSVSKENSTAS EEEEEEECCCCCCHH	27.09	21890473
706	Ubiquitination	FLVSVSKENSTASEV EEEEECCCCCCHHHH	49.24	21890473
711	Ubiquitination	SKENSTASEVLDSLS CCCCCCHHHHHHHHH	28.46	29967540
713	Ubiquitination	ENSTASEVLDSLSQS CCCCHHHHHHHHHHC	7.15	29967540
724	Ubiquitination	LSQSVHVKPENLRLA HHHCCCCCHHHCHHH	31.56	29967540
735	Ubiquitination	LRLAEVIKNRFHRVF CHHHHHHHHCCCEEE	47.44	29967540
737	Ubiquitination	LAEVIKNRFHRVFLP HHHHHHHCCCEEECC	24.60	21890473
738	Ubiquitination	AEVIKNRFHRVFLPS HHHHHHCCCEEECCC	6.36	21890473
739	Ubiquitination	EVIKNRFHRVFLPSH HHHHHCCCEEECCCC	23.04	21890473
741	Ubiquitination	IKNRFHRVFLPSHSL HHHCCCEEECCCCCC	4.31	21890473
742	Ubiquitination	KNRFHRVFLPSHSLD HHCCCEEECCCCCCC	9.29	21890473
744	Ubiquitination	RFHRVFLPSHSLDTV CCCEEECCCCCCCCC	20.66	29967540
745	Phosphorylation	FHRVFLPSHSLDTVS CCEEECCCCCCCCCC	28.05	27251275
747	Phosphorylation	RVFLPSHSLDTVSPS EEECCCCCCCCCCHH	32.07	27251275
751	Ubiquitination	PSHSLDTVSPSDTLL CCCCCCCCCHHHHHH	8.71	21890473
752	Ubiquitination	SHSLDTVSPSDTLLC CCCCCCCCHHHHHHH	22.30	21890473
752	Ubiquitination	SHSLDTVSPSDTLLC CCCCCCCCHHHHHHH	22.30	21890473
753	Ubiquitination	HSLDTVSPSDTLLCF CCCCCCCHHHHHHHH	31.71	21890473
754	Ubiquitination	SLDTVSPSDTLLCFE CCCCCCHHHHHHHHH	35.40	21890473
755	Ubiquitination	LDTVSPSDTLLCFEL CCCCCHHHHHHHHHH	44.77	21890473
756	Ubiquitination	DTVSPSDTLLCFELL CCCCHHHHHHHHHHH	26.43	21890473
764	Phosphorylation	LLCFELLSSELAKER HHHHHHHCHHHHHCC	34.10	27251275
765	Phosphorylation	LCFELLSSELAKERV HHHHHHCHHHHHCCE	36.28	27251275
815	Ubiquitination	CTRCYRVGYCNQLCQ HHHHHHHHHHHHHHH	16.57	29967540
816	Phosphorylation	TRCYRVGYCNQLCQK HHHHHHHHHHHHHHH	5.83	28152594
823	Ubiquitination	YCNQLCQKTHWPDHK HHHHHHHHCCCCCCC	41.16	-
825	Ubiquitination	NQLCQKTHWPDHKGL HHHHHHCCCCCCCCC	40.90	29967540
826	Ubiquitination	QLCQKTHWPDHKGLC HHHHHCCCCCCCCCC	12.78	29967540
827	Ubiquitination	LCQKTHWPDHKGLCR HHHHCCCCCCCCCCC	26.65	29967540
836	Ubiquitination	HKGLCRPENIGYPFL CCCCCCHHHCCCCEE	41.97	29967540
838	Ubiquitination	GLCRPENIGYPFLVS CCCCHHHCCCCEEEE	5.51	29967540
846 (in isoform 1)	Phosphorylation	-	3.42	27251275
866 (in isoform 1)	Phosphorylation	-	12.78	27251275
886	Phosphorylation	RMALESQSPGCTTLL CCCCCCCCCCCEEEE	32.32	28348404
890	Phosphorylation	ESQSPGCTTLLSTGS CCCCCCCEEEEECCC	26.79	28348404
891	Phosphorylation	SQSPGCTTLLSTGSL CCCCCCEEEEECCCC	29.76	21815630
894	Phosphorylation	PGCTTLLSTGSLEAG CCCEEEEECCCCCCC	33.56	28348404
895	Phosphorylation	GCTTLLSTGSLEAGD CCEEEEECCCCCCCC	30.66	28348404
897	Phosphorylation	TTLLSTGSLEAGDSE EEEEECCCCCCCCCC	24.11	28348404
903	Phosphorylation	GSLEAGDSERDPIQP CCCCCCCCCCCCCCC	33.35	27251275
941	Phosphorylation	DRGPVPSTSGISSEM CCCCCCCCCCCCHHH	25.54	28985074
945	Phosphorylation	VPSTSGISSEMLASG CCCCCCCCHHHHHCC	24.62	28985074
946	Phosphorylation	PSTSGISSEMLASGP CCCCCCCHHHHHCCC	25.71	28985074
998 (in isoform 1)	Phosphorylation	-	56.30	27251275
1077	Ubiquitination	PEVLAPEEAWYCPQC CCCCCCHHHHCCCHH	43.36	23000965
1079	Ubiquitination	VLAPEEAWYCPQCKQ CCCCHHHHCCCHHHH	9.88	23000965
1081	Ubiquitination	APEEAWYCPQCKQHR CCHHHHCCCHHHHHH	0.99	23000965
1092	Ubiquitination	KQHREASKQLLLWRL HHHHHHHHHHHHHHC	52.60	23000965
1094	Ubiquitination	HREASKQLLLWRLPN HHHHHHHHHHHHCCC	4.95	23000965
1096	Ubiquitination	EASKQLLLWRLPNVL HHHHHHHHHHCCCEE	3.21	23000965
1105	Ubiquitination	RLPNVLIVQLKRFSF HCCCEEEEEECCCCC	4.82	21890473
1107	Ubiquitination	PNVLIVQLKRFSFRS CCEEEEEECCCCCHH	2.73	23000965
1109	Ubiquitination	VLIVQLKRFSFRSFI EEEEEECCCCCHHHH	40.82	23000965
1111	Phosphorylation	IVQLKRFSFRSFIWR EEEECCCCCHHHHHH	24.63	24719451
1120	Ubiquitination	RSFIWRDKINDLVEF HHHHHHHHCCHHEEC	34.53	23000965
1120 (in isoform 1)	Ubiquitination	-	34.53	21890473
1120 (in isoform 3)	Ubiquitination	-	34.53	21890473
1121	Ubiquitination	SFIWRDKINDLVEFP HHHHHHHCCHHEECC	5.93	23000965
1122	Ubiquitination	FIWRDKINDLVEFPV HHHHHHCCHHEECCC	42.16	23000965
1123	Ubiquitination	IWRDKINDLVEFPVR HHHHHCCHHEECCCC	56.41	23000965
1124	Ubiquitination	WRDKINDLVEFPVRN HHHHCCHHEECCCCC	3.25	23000965
1125	Ubiquitination	RDKINDLVEFPVRNL HHHCCHHEECCCCCC	8.75	23000965
1127	Ubiquitination	KINDLVEFPVRNLDL HCCHHEECCCCCCCH	5.44	23000965
1129	Ubiquitination	NDLVEFPVRNLDLSK CHHEECCCCCCCHHH	8.44	23000965
1131	Ubiquitination	LVEFPVRNLDLSKFC HEECCCCCCCHHHHH	37.83	23000965
1136	Ubiquitination	VRNLDLSKFCIGQKE CCCCCHHHHHCCCCC	52.10	23000965
1138	Ubiquitination	NLDLSKFCIGQKEEQ CCCHHHHHCCCCCCC	3.82	23000965
1140	Ubiquitination	DLSKFCIGQKEEQLP CHHHHHCCCCCCCCC	33.42	23000965
1142	Ubiquitination	SKFCIGQKEEQLPSY HHHHCCCCCCCCCCC	58.99	23000965
1143	Ubiquitination	KFCIGQKEEQLPSYD HHHCCCCCCCCCCCC	42.99	23000965
1144	Ubiquitination	FCIGQKEEQLPSYDL HHCCCCCCCCCCCCH	65.54	23000965
1145	Ubiquitination	CIGQKEEQLPSYDLY HCCCCCCCCCCCCHH	60.82	23000965
1146	Ubiquitination	IGQKEEQLPSYDLYA CCCCCCCCCCCCHHE	3.26	23000965
1147	Ubiquitination	GQKEEQLPSYDLYAV CCCCCCCCCCCHHEE	30.45	23000965
1148	Phosphorylation	QKEEQLPSYDLYAVI CCCCCCCCCCHHEEH	39.61	28674151
1167	Phosphorylation	GMIGGHYTACARLPN CCCCCEEEEEECCCC	15.02	28674151
1171	Ubiquitination	GHYTACARLPNDRSS CEEEEEECCCCCCCC	51.03	23000965
1173	Ubiquitination	YTACARLPNDRSSQR EEEEECCCCCCCCCC	34.81	21890473
1175	Ubiquitination	ACARLPNDRSSQRSD EEECCCCCCCCCCCC	50.31	21890473
1178	Ubiquitination	RLPNDRSSQRSDVGW CCCCCCCCCCCCCCE	30.43	23000965
1179	Ubiquitination	LPNDRSSQRSDVGWR CCCCCCCCCCCCCEE	50.58	23000965
1180	Ubiquitination	PNDRSSQRSDVGWRL CCCCCCCCCCCCEEE	36.45	23000965
1182	Ubiquitination	DRSSQRSDVGWRLFD CCCCCCCCCCEEECC	45.17	23000965
1183	Ubiquitination	RSSQRSDVGWRLFDD CCCCCCCCCEEECCC	9.27	23000965
1187	Ubiquitination	RSDVGWRLFDDSTVT CCCCCEEECCCCCEE	4.44	23000965
1189	Ubiquitination	DVGWRLFDDSTVTTV CCCEEECCCCCEEEE	54.25	23000965
1191	Ubiquitination	GWRLFDDSTVTTVDE CEEECCCCCEEEECH	26.99	23000965
1192	Ubiquitination	WRLFDDSTVTTVDES EEECCCCCEEEECHH	28.94	23000965
1193	Ubiquitination	RLFDDSTVTTVDESQ EECCCCCEEEECHHH	4.97	23000965
1194	Ubiquitination	LFDDSTVTTVDESQV ECCCCCEEEECHHHH	22.61	23000965
1195	Ubiquitination	FDDSTVTTVDESQVV CCCCCEEEECHHHHH	22.94	23000965
1196	Ubiquitination	DDSTVTTVDESQVVT CCCCEEEECHHHHHH	5.85	23000965
1197	Ubiquitination	DSTVTTVDESQVVTR CCCEEEECHHHHHHH	47.97	23000965
1205	Phosphorylation	ESQVVTRYAYVLFYR HHHHHHHEEEEEEEC	7.91	28152594
1206	Ubiquitination	SQVVTRYAYVLFYRR HHHHHHEEEEEEECC	5.67	21890473
1207	Phosphorylation	QVVTRYAYVLFYRRR HHHHHEEEEEEECCC	6.69	28152594
1207	Ubiquitination	QVVTRYAYVLFYRRR HHHHHEEEEEEECCC	6.69	21890473
1208	Ubiquitination	VVTRYAYVLFYRRRN HHHHEEEEEEECCCC	1.96	23000965
1210	Ubiquitination	TRYAYVLFYRRRNSP HHEEEEEEECCCCCC	2.96	23000965
1211	Ubiquitination	RYAYVLFYRRRNSPV HEEEEEEECCCCCCC	10.07	23000965
1212 (in isoform 1)	Phosphorylation	-	24.61	24719451
1220	Ubiquitination	RRNSPVERPPRAGHS CCCCCCCCCCCCCCC	46.92	23000965
1221	Ubiquitination	RNSPVERPPRAGHSE CCCCCCCCCCCCCCC	14.82	21890473
1221	Ubiquitination	RNSPVERPPRAGHSE CCCCCCCCCCCCCCC	14.82	23000965
1222	Ubiquitination	NSPVERPPRAGHSEH CCCCCCCCCCCCCCC	45.00	23000965
1223	Ubiquitination	SPVERPPRAGHSEHH CCCCCCCCCCCCCCC	56.75	23000965
1224	Ubiquitination	PVERPPRAGHSEHHP CCCCCCCCCCCCCCC	26.31	21890473
1225	Ubiquitination	VERPPRAGHSEHHPD CCCCCCCCCCCCCCC	26.57	21890473
1226	Ubiquitination	ERPPRAGHSEHHPDL CCCCCCCCCCCCCCH	29.09	23000965
1227	Ubiquitination	RPPRAGHSEHHPDLG CCCCCCCCCCCCCHH	37.39	23000965
1228	Ubiquitination	PPRAGHSEHHPDLGP CCCCCCCCCCCCHHH	40.31	23000965
1229	Ubiquitination	PRAGHSEHHPDLGPA CCCCCCCCCCCHHHH	40.57	23000965
1230	Ubiquitination	RAGHSEHHPDLGPAA CCCCCCCCCCHHHHH	17.33	23000965
1232	Ubiquitination	GHSEHHPDLGPAAEA CCCCCCCCHHHHHHH	60.96	23000965
1233	Ubiquitination	HSEHHPDLGPAAEAA CCCCCCCHHHHHHHH	11.88	23000965
1236	Ubiquitination	HHPDLGPAAEAAASQ CCCCHHHHHHHHHHH	19.01	23000965
1237	Ubiquitination	HPDLGPAAEAAASQA CCCHHHHHHHHHHHH	15.30	23000965
1238	Ubiquitination	PDLGPAAEAAASQAS CCHHHHHHHHHHHHH	40.73	23000965
1239	Ubiquitination	DLGPAAEAAASQASR CHHHHHHHHHHHHHH	12.00	23000965
1240	Ubiquitination	LGPAAEAAASQASRI HHHHHHHHHHHHHHH	10.11	23000965
1241	Ubiquitination	GPAAEAAASQASRIW HHHHHHHHHHHHHHH	14.82	23000965
1242	Phosphorylation	PAAEAAASQASRIWQ HHHHHHHHHHHHHHH	22.89	17525332
1242	Ubiquitination	PAAEAAASQASRIWQ HHHHHHHHHHHHHHH	22.89	23000965
1243	Ubiquitination	AAEAAASQASRIWQE HHHHHHHHHHHHHHH	38.33	23000965
1244	Ubiquitination	AEAAASQASRIWQEL HHHHHHHHHHHHHHH	9.78	23000965
1245	Phosphorylation	EAAASQASRIWQELE HHHHHHHHHHHHHHH	19.36	28555341
1245	Ubiquitination	EAAASQASRIWQELE HHHHHHHHHHHHHHH	19.36	23000965
1246	Ubiquitination	AAASQASRIWQELEA HHHHHHHHHHHHHHC	36.86	23000965
1247	Ubiquitination	AASQASRIWQELEAE HHHHHHHHHHHHHCC	4.05	23000965
1260 (in isoform 4)	Phosphorylation	-	67.25	28796482
1261 (in isoform 4)	Phosphorylation	-	31.65	28796482
1262 (in isoform 4)	Phosphorylation	-	35.26	28796482
1273 (in isoform 3)	Phosphorylation	-	7.54	28796482
1274 (in isoform 3)	Phosphorylation	-	8.34	28796482
1275 (in isoform 3)	Phosphorylation	-	17.48	28796482
1364 (in isoform 7)	Phosphorylation	-		28796482
1365 (in isoform 7)	Phosphorylation	-		28796482
1366 (in isoform 7)	Phosphorylation	-		28796482
1376 (in isoform 6)	Phosphorylation	-		28796482
1377 (in isoform 6)	Phosphorylation	-		28796482
1378 (in isoform 6)	Phosphorylation	-		28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACDSB_HUMAN	ACADSB	physical	19615732
KCC2G_HUMAN	CAMK2G	physical	19615732
CDK1_HUMAN	CDK1	physical	19615732
XPO2_HUMAN	CSE1L	physical	19615732
DMWD_HUMAN	DMWD	physical	19615732
HMOX2_HUMAN	HMOX2	physical	19615732
SYIC_HUMAN	IARS	physical	19615732
ODPA_HUMAN	PDHA1	physical	19615732
PYGL_HUMAN	PYGL	physical	19615732
AAAT_HUMAN	SLC1A5	physical	19615732
RO52_HUMAN	TRIM21	physical	19615732
SUCB2_HUMAN	SUCLG2	physical	19615732
HERC2_HUMAN	HERC2	physical	19615732
LPPRC_HUMAN	LRPPRC	physical	19615732
GCN1_HUMAN	GCN1L1	physical	19615732
PARK7_HUMAN	PARK7	physical	19615732
NU160_HUMAN	NUP160	physical	19615732
TNPO3_HUMAN	TNPO3	physical	19615732
FKBP8_HUMAN	FKBP8	physical	19615732
LAT_HUMAN	LAT	physical	19615732
S61A1_HUMAN	SEC61A1	physical	19615732
TMM33_HUMAN	TMEM33	physical	19615732
S61A2_HUMAN	SEC61A2	physical	19615732
UN45A_HUMAN	UNC45A	physical	19615732
SRPRB_HUMAN	SRPRB	physical	19615732
NEUL4_HUMAN	NEURL4	physical	19615732
ATAD1_HUMAN	ATAD1	physical	19615732
DOCK7_HUMAN	DOCK7	physical	19615732
SAAL1_HUMAN	SAAL1	physical	19615732
BIRC2_HUMAN	BIRC2	physical	21849505
BIRC3_HUMAN	BIRC3	physical	21849505
XIAP_HUMAN	XIAP	physical	21849505
HIF1A_HUMAN	HIF1A	physical	22128162
SIAH2_HUMAN	SIAH2	physical	22128162
SIAH1_HUMAN	SIAH1	physical	22128162
XRN2_HUMAN	XRN2	physical	22939629
SIAH1_HUMAN	SIAH1	physical	23500468
FLNA_HUMAN	FLNA	physical	23500468
SIAH2_HUMAN	SIAH2	physical	23500468
LTOR4_HUMAN	LAMTOR4	physical	23500468
CKAP5_HUMAN	CKAP5	physical	23500468
ECEL1_HUMAN	ECEL1	physical	23500468
RING2_HUMAN	RNF2	physical	23500468
U520_HUMAN	SNRNP200	physical	23500468
ROAA_HUMAN	HNRNPAB	physical	23500468
HS90A_HUMAN	HSP90AA1	physical	24356957
HSP74_HUMAN	HSPA4	physical	24356957
UBC_HUMAN	UBC	physical	24356957
SE1L1_HUMAN	SEL1L	physical	24356957
SYVN1_HUMAN	SYVN1	physical	24356957
FAF2_HUMAN	FAF2	physical	24356957
DERL1_HUMAN	DERL1	physical	24356957
CD2B2_HUMAN	CD2BP2	physical	25036637
HS90A_HUMAN	HSP90AA1	physical	26808260
CHIP_HUMAN	STUB1	physical	26808260
HDAC1_HUMAN	HDAC1	physical	27517492
HDAC2_HUMAN	HDAC2	physical	27517492

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.
PubMed: 19413330

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1242, AND MASSSPECTROMETRY.
PubMed: 17525332

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.
PubMed: 15302935