S61A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S61A2_HUMAN
• UniProt AC: Q9H9S3
• Protein Name: Protein transport protein Sec61 subunit alpha isoform 2
• Gene Name: SEC61A2
• Organism: Homo sapiens (Human).
• Sequence Length: 476
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity)..
• Protein Sequence: MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MGIKFLEVIKP ----CCCCHHHHHHH	37.86	21890473
4	Ubiquitination	----MGIKFLEVIKP ----CCCCHHHHHHH	37.86	21890473
10	Ubiquitination	IKFLEVIKPFCAVLP CCHHHHHHHHHHHCH	36.90	-
21	Ubiquitination	AVLPEIQKPERKIQF HHCHHCCCCCHHHHH	55.28	-
55	Phosphorylation	IPLFGIMSSDSADPF CHHHCCCCCCCCCCC	29.13	-
75	Phosphorylation	ILASNRGTLMELGIS HHHCCCCCCHHCCCC	21.50	-
82	Phosphorylation	TLMELGISPIVTSGL CCHHCCCCHHHCHHH	13.53	-
86	Phosphorylation	LGISPIVTSGLIMQL CCCCHHHCHHHHHHH	20.14	-
87	Phosphorylation	GISPIVTSGLIMQLL CCCHHHCHHHHHHHH	22.25	-
105	Phosphorylation	KIIEVGDTPKDRALF EEEEECCCHHHHHHH	26.72	21815630
107 (in isoform 2)	Ubiquitination	-	63.04	21890473
107 (in isoform 1)	Ubiquitination	-	63.04	21890473
107	2-Hydroxyisobutyrylation	IEVGDTPKDRALFNG EEECCCHHHHHHHHH	63.04	-
107	Ubiquitination	IEVGDTPKDRALFNG EEECCCHHHHHHHHH	63.04	21906983
268 (in isoform 2)	Ubiquitination	-	35.80	21890473
268	Ubiquitination	FRVDLPIKSARYRGQ CCEECEECCCCCCCC	35.80	21906983
268 (in isoform 1)	Ubiquitination	-	35.80	21890473
366	Ubiquitination	VHVVVYIIFMLGSCA HHHHHHHHHHHHHHH	0.63	21890473
370	Ubiquitination	VYIIFMLGSCAFFSK HHHHHHHHHHHHHCC	14.64	21890473
373	Ubiquitination	IFMLGSCAFFSKTWI HHHHHHHHHHCCHHE	15.37	21890473
388 (in isoform 2)	Ubiquitination	-	55.47	21890473
388	Ubiquitination	EVSGSSAKDVAKQLK ECCCCCHHHHHHHHH	55.47	21890473
388 (in isoform 1)	Ubiquitination	-	55.47	21890473
392 (in isoform 2)	Ubiquitination	-	56.88	21890473
392	2-Hydroxyisobutyrylation	SSAKDVAKQLKEQQM CCHHHHHHHHHHHHH	56.88	-
392 (in isoform 1)	Ubiquitination	-	56.88	21890473
392	Ubiquitination	SSAKDVAKQLKEQQM CCHHHHHHHHHHHHH	56.88	21890473
395 (in isoform 1)	Ubiquitination	-	51.49	21890473
395	Ubiquitination	KDVAKQLKEQQMVMR HHHHHHHHHHHHHHC	51.49	21890473
395 (in isoform 2)	Ubiquitination	-	51.49	21890473
405	Methylation	QMVMRGHRDTSMVHE HHHHCCCCCHHHHHH	52.29	115493593

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S61A2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S61A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S61A2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S61A2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.