BIRC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BIRC1_HUMAN
• UniProt AC: Q13075
• Protein Name: Baculoviral IAP repeat-containing protein 1
• Gene Name: NAIP
• Organism: Homo sapiens (Human).
• Sequence Length: 1403
• Protein Description: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.; Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila..
• Protein Sequence: MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
137	Ubiquitination	KDVGNIAKYDIRVKN CCCCCHHHHHHHHHC	39.39	21890473
165	Phosphorylation	EEEARLASFRNWPFY HHHHHHHHHCCCCCH	29.36	24719451
420	Phosphorylation	SASFRHMSLLDISSD HHHHHHHHHHCCCCC	21.47	-
531	Phosphorylation	LEKEGSVTEMCVRNI HHCCCCHHHHHHHHH	21.50	22468782
628	Phosphorylation	RLRKFMVYFGKNQSL HHHHHHHHHCCCCHH	8.53	-
675	Phosphorylation	KSYMERLSLRNKATA HHHHHHHHCCCHHHH	31.35	23532336
780	Phosphorylation	YHLKQINSPMMTVSA CCHHHCCCCCEEHHH	18.79	30576142
800	Phosphorylation	NYVSSLPSTKAGPKI HHHHCCCCCCCCHHH	48.08	30576142
932	Phosphorylation	TSPRAHFSVLETCFD CCCCCCCHHHHHHCC	18.87	28857561
982	Phosphorylation	MDMQRRASPDLSTGY HHHHHHCCCCCCCCC	19.69	28450419
987	Phosphorylation	RASPDLSTGYWKLSP HCCCCCCCCCCCCCH	41.40	-
989	Phosphorylation	SPDLSTGYWKLSPKQ CCCCCCCCCCCCHHH	10.23	-
1043	Phosphorylation	HSRGFIESIRPALEL CCCCHHHHHHHHHHH	21.05	-
1051	Phosphorylation	IRPALELSKASVTKC HHHHHHHHHCCCCEE	19.46	-
1056	Phosphorylation	ELSKASVTKCSISKL HHHHCCCCEECCHHH	24.68	29666759
1066	Phosphorylation	SISKLELSAAEQELL CCHHHCCCHHHHHHH	18.96	24043423
1075	Phosphorylation	AEQELLLTLPSLESL HHHHHHHHCCCCCCC	36.27	24043423
1078	Phosphorylation	ELLLTLPSLESLEVS HHHHHCCCCCCCEEC	48.13	24043423
1081	Phosphorylation	LTLPSLESLEVSGTI HHCCCCCCCEECCCC	34.81	24043423
1085	Phosphorylation	SLESLEVSGTIQSQD CCCCCEECCCCCCHH	22.35	24043423
1087	Phosphorylation	ESLEVSGTIQSQDQI CCCEECCCCCCHHHC	14.34	24043423
1090	Phosphorylation	EVSGTIQSQDQIFPN EECCCCCCHHHCCCC	31.69	24043423
1168	Phosphorylation	HLKCNFFSDFGSLMT EEECCCHHCHHHHHH	28.08	28509920
1172	Phosphorylation	NFFSDFGSLMTMLVS CCHHCHHHHHHHHHH	18.24	28509920
1175	Phosphorylation	SDFGSLMTMLVSCKK HCHHHHHHHHHHCCC	16.79	28634298
1179	Phosphorylation	SLMTMLVSCKKLTEI HHHHHHHHCCCCCCC	19.09	28509920
1273	Phosphorylation	RVLSFFKTLNDDSVV HHHHHHHCCCCCCHH	26.15	29083192
1278	Phosphorylation	FKTLNDDSVVEIAKV HHCCCCCCHHHHEEE	30.81	29083192
1398	Phosphorylation	QKWILPFSPIIQK-- HHHHCCCCCCCCC--	17.16	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BIRC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BIRC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BIRC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DBLOH_HUMAN	DIABLO	physical	15280366
XAF1_HUMAN	XAF1	physical	17613533
M3K7_HUMAN	MAP3K7	physical	11865055

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.