SLAP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLAP2_HUMAN
• UniProt AC: Q9H6Q3
• Protein Name: Src-like-adapter 2
• Gene Name: SLA2
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Cytoplasm.; Isoform 1: Cell membrane. Cytoplasmic vesicle. Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.; Isoform 2: Cytoplasm . May be cytoplasmic and is not localized to membranes.
• Protein Description: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins..
• Protein Sequence: MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEGLRESLSFYISLNDEAVSLDDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGSLPSRRK ------CCCCCCCCC	37.58	-
2	Myristoylation	------MGSLPSRRK ------CCCCCCCCC	37.58	11696592
6	Phosphorylation	--MGSLPSRRKSLPS --CCCCCCCCCCCCC	50.43	23532336
10	Phosphorylation	SLPSRRKSLPSPSLS CCCCCCCCCCCCCCC	43.64	23401153
13	Phosphorylation	SRRKSLPSPSLSSSV CCCCCCCCCCCCCCC	32.20	29978859
15	Phosphorylation	RKSLPSPSLSSSVQG CCCCCCCCCCCCCCC	45.26	29978859
17	Phosphorylation	SLPSPSLSSSVQGQG CCCCCCCCCCCCCCC	25.55	29978859
18	Phosphorylation	LPSPSLSSSVQGQGP CCCCCCCCCCCCCCC	39.56	29978859
19	Phosphorylation	PSPSLSSSVQGQGPV CCCCCCCCCCCCCCC	18.32	29978859
27	Phosphorylation	VQGQGPVTMEAERSK CCCCCCCCCEEEHHC	16.66	26074081
33	Phosphorylation	VTMEAERSKATAVAL CCCEEEHHCCEEEEE	20.39	26074081
34	Ubiquitination	TMEAERSKATAVALG CCEEEHHCCEEEEEC	56.85	29967540
52	Phosphorylation	AGGPAELSLRLGEPL CCCCCEEEEECCCCE	11.71	24719451
103	Ubiquitination	YEGLSREKAEELLLL HCCCCHHHHHHHEEC	61.05	-
129	Phosphorylation	ESQTRRGSYSLSVRL ECCCCCCEEEEEEEE	15.10	30108239
130	Phosphorylation	SQTRRGSYSLSVRLS CCCCCCEEEEEEEEC	19.22	30108239
131	Phosphorylation	QTRRGSYSLSVRLSR CCCCCEEEEEEEECC	18.83	30108239
133	Phosphorylation	RRGSYSLSVRLSRPA CCCEEEEEEEECCCC	10.15	24719451
159	Phosphorylation	CLDNGWLYISPRLTF ECCCCEEEECCCCCC	7.89	26074081
161	Phosphorylation	DNGWLYISPRLTFPS CCCEEEECCCCCCHH	7.15	26074081
202	Ubiquitination	RAGPLPGKDIPLPVT ECCCCCCCCCCCCEE	51.01	22505724

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLAP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLAP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLAP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD3Z_HUMAN	CD247	physical	11891219
ZAP70_HUMAN	ZAP70	physical	11891219
CBL_HUMAN	CBL	physical	11891219
CBL_HUMAN	CBL	physical	17353186
CSF1_HUMAN	CSF1	physical	17353186
CBL_HUMAN	CBL	physical	11696592
CBL_HUMAN	CBL	physical	16623714
CBL_HUMAN	CBL	physical	12527895

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Functional cloning of Src-like adapter protein-2 (SLAP-2), a novelinhibitor of antigen receptor signaling.";
Holland S.J., Liao X.C., Mendenhall M.K., Zhou X., Pardo J., Chu P.,Spencer C., Fu A.C., Sheng N., Yu P., Pali E., Nagin A., Shen M.,Yu S., Chan E., Wu X., Li C., Woisetschlager M., Aversa G.,Kolbinger F., Bennett M.K., Molineaux S., Luo Y., Payan D.G.,Mancebo H.S.Y., Wu J.;
J. Exp. Med. 194:1263-1276(2001).
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), CHARACTERIZATION, FUNCTION,MYRISTOYLATION AT GLY-2, INTERACTION WITH CBL, AND MUTAGENESIS OFGLY-2.
PubMed: 11696592