PZRN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PZRN4_HUMAN
• UniProt AC: Q6ZMN7
• Protein Name: PDZ domain-containing RING finger protein 4
• Gene Name: PDZRN4
• Organism: Homo sapiens (Human).
• Sequence Length: 1036
• Protein Sequence: MGFALERFAEAVDPALECKLCGQVLEEPLCTPCGHVFCASCLLPWAVRRRRCPLQCQPLAPGELYRVLPLRSLIQKLRVQCDYRARGCGHSVRLHELEAHVEHCDFGPARRLRSRGGCASGLGGGEVPARGGCGPTPRAGRGGGARGGPPGGRWGRGRGPGPRVLAWRRREKALLAQLWALQGEVQLTARRYQEKFTQYMAHVRNFVGDLGGGHRRDGEHKPFTIVLERENDTLGFNIIGGRPNQNNQEGTSTEGIYVSKILENGPADRADGLEIHDKIMEVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFLEELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESLRNDESSEQENAAEDPNSTSLKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDEDCERFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIELECQNIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHPEKSDKDSSSAYNTAESCRSTPLTVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKESTSTKAKTTEQGCSAESKEKVLEGSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQLIQQKSAVEYAQSQLSLVSMCKESQKCSEPKMEWKVKIRSDGTRYITKRPVRDRILKERALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFMMRSRLECLKESPQSGSEGKKEINIIELSHKKMMKKRNKKILDNWMTIQELMTHGAKSPDGTRVHNAFLSVTTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19 (in isoform 2)	Phosphorylation	-	37.12	-
114	Phosphorylation	GPARRLRSRGGCASG CHHHHHHHCCCCCCC	39.61	22210691
136	Phosphorylation	ARGGCGPTPRAGRGG CCCCCCCCCCCCCCC	15.64	22210691
233	Phosphorylation	VLERENDTLGFNIIG EEEECCCCCCEEEEC	40.12	23917254
314	Phosphorylation	VVQVLRRTPLSRPAY EEEEEECCCCCCCCC	23.34	26356563
317	Phosphorylation	VLRRTPLSRPAYGMA EEECCCCCCCCCCCC	37.10	26356563
321	Phosphorylation	TPLSRPAYGMASEVQ CCCCCCCCCCCCHHH	15.32	26356563
325	Phosphorylation	RPAYGMASEVQLMNA CCCCCCCCHHHHCCC	29.43	26356563
333	Phosphorylation	EVQLMNASTQTDITF HHHHCCCCCCCCCCH	18.95	26356563
334	Phosphorylation	VQLMNASTQTDITFE HHHCCCCCCCCCCHH	32.83	26356563
336	Phosphorylation	LMNASTQTDITFEHI HCCCCCCCCCCHHHH	29.47	26356563
339	Phosphorylation	ASTQTDITFEHIMAL CCCCCCCCHHHHHHH	26.27	26356563
567	Phosphorylation	ESLRNDESSEQENAA HHHCCCCCHHHHHHC	41.88	27251275
568	Phosphorylation	SLRNDESSEQENAAE HHCCCCCHHHHHHCC	41.05	27251275
712	Phosphorylation	GGFRNYNTSIDMQRG CCCCCCCCCEEECCC	19.39	29083192
713	Phosphorylation	GFRNYNTSIDMQRGK CCCCCCCCEEECCCC	16.98	29083192
744	Phosphorylation	SAYNTAESCRSTPLT HHHHCHHHHCCCCCC	16.62	22468782
748	Phosphorylation	TAESCRSTPLTVDRS CHHHHCCCCCCCCCC	11.72	22468782
751	Phosphorylation	SCRSTPLTVDRSPDS HHCCCCCCCCCCCCC	22.89	28348404
755	Phosphorylation	TPLTVDRSPDSSLPR CCCCCCCCCCCCCCC	28.70	24719451
758	Phosphorylation	TVDRSPDSSLPRVIN CCCCCCCCCCCCEEE	36.84	29262532
759	Phosphorylation	VDRSPDSSLPRVINL CCCCCCCCCCCEEEC	50.18	24719451
774	Phosphorylation	TNKKNLRSTMAATQS CCCCCHHHHHHHCCC	26.21	30576142
775	Phosphorylation	NKKNLRSTMAATQSS CCCCHHHHHHHCCCC	12.37	30576142
779	Phosphorylation	LRSTMAATQSSSGQS HHHHHHHCCCCCCCC	21.32	30576142
782	Phosphorylation	TMAATQSSSGQSSKE HHHHCCCCCCCCCCC	28.77	30576142
783	Phosphorylation	MAATQSSSGQSSKES HHHCCCCCCCCCCCC	46.21	30576142
786	Phosphorylation	TQSSSGQSSKESTST CCCCCCCCCCCCCCC	47.07	30576142
791	Phosphorylation	GQSSKESTSTKAKTT CCCCCCCCCCCCCCC	41.32	30576142
793	Phosphorylation	SSKESTSTKAKTTEQ CCCCCCCCCCCCCCC	34.80	30576142
807	Acetylation	QGCSAESKEKVLEGS CCCCHHHHHHHHCCC	53.73	11790827
831	Phosphorylation	SEHIPYLSPYHSSSY HHCCCCCCCCCCCCC	19.98	22210691
833	Phosphorylation	HIPYLSPYHSSSYRY CCCCCCCCCCCCCCC	15.80	22210691
838	Phosphorylation	SPYHSSSYRYANIPA CCCCCCCCCCCCCCH	15.02	22210691
923	Phosphorylation	LKIKEERSGMTTDDD HHHHHHHCCCCCCCC	35.87	29978859
926	Phosphorylation	KEERSGMTTDDDTMS HHHHCCCCCCCCHHH	30.51	29978859
927	Phosphorylation	EERSGMTTDDDTMSE HHHCCCCCCCCHHHH	28.65	30576142
931	Phosphorylation	GMTTDDDTMSEMKMG CCCCCCCHHHHHHHH	29.59	29978859
933	Phosphorylation	TTDDDTMSEMKMGRY CCCCCHHHHHHHHCC	36.31	30576142
940	Phosphorylation	SEMKMGRYWSKEERK HHHHHHCCCCHHHHH	14.33	22817900
993	Acetylation	NIIELSHKKMMKKRN CEEHHCHHHHHHHHC	38.70	21339330
994	Acetylation	IIELSHKKMMKKRNK EEHHCHHHHHHHHCH	38.51	21339330
997	Acetylation	LSHKKMMKKRNKKIL HCHHHHHHHHCHHHH	45.11	21339330
1020	Phosphorylation	LMTHGAKSPDGTRVH HHHCCCCCCCCCCCC	27.91	22210691
1024	Phosphorylation	GAKSPDGTRVHNAFL CCCCCCCCCCCCEEE	36.58	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PZRN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PZRN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PZRN4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PZRN4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.