| UniProt ID | OCTC_HUMAN | |
|---|---|---|
| UniProt AC | Q9UKG9 | |
| Protein Name | Peroxisomal carnitine O-octanoyltransferase | |
| Gene Name | CROT | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 612 | |
| Subcellular Localization | Peroxisome . | |
| Protein Description | Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.. | |
| Protein Sequence | MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAALTSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFVLSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRFVVACSAWKSCPETDAEKLVQLTFCAFHDMIQLMNSTHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MENQLAKS -------CCCCCCCC | 11.15 | 22814378 | |
| 7 | Ubiquitination | -MENQLAKSTEERTF -CCCCCCCCCCCCEE | 67.51 | 24816145 | |
| 7 | Acetylation | -MENQLAKSTEERTF -CCCCCCCCCCCCEE | 67.51 | 25953088 | |
| 35 | Phosphorylation | LEESLKKYLESVKPF HHHHHHHHHHHCCCC | 17.70 | 22461510 | |
| 38 | Phosphorylation | SLKKYLESVKPFANQ HHHHHHHHCCCCCCH | 32.61 | 22461510 | |
| 40 | Succinylation | KKYLESVKPFANQEE HHHHHHCCCCCCHHH | 43.63 | - | |
| 40 | Succinylation | KKYLESVKPFANQEE HHHHHHCCCCCCHHH | 43.63 | - | |
| 40 | Ubiquitination | KKYLESVKPFANQEE HHHHHHCCCCCCHHH | 43.63 | 29967540 | |
| 57 | Succinylation | KTEEIVQKFQSGIGE HHHHHHHHHHHCHHH | 34.18 | - | |
| 57 | Succinylation | KTEEIVQKFQSGIGE HHHHHHHHHHHCHHH | 34.18 | - | |
| 57 | Ubiquitination | KTEEIVQKFQSGIGE HHHHHHHHHHHCHHH | 34.18 | 29967540 | |
| 65 | Ubiquitination | FQSGIGEKLHQKLLE HHHCHHHHHHHHHHH | 46.16 | 29967540 | |
| 69 | Ubiquitination | IGEKLHQKLLERAKG HHHHHHHHHHHHHCC | 44.27 | 29967540 | |
| 85 | Ubiquitination | RNWLEEWWLNVAYLD CCHHHHHHEEEEEEE | 4.95 | 29967540 | |
| 93 | Ubiquitination | LNVAYLDVRIPSQLN EEEEEEECCCCCCCC | 5.73 | 29967540 | |
| 97 | Ubiquitination | YLDVRIPSQLNVNFA EEECCCCCCCCCCEE | 44.95 | 29967540 | |
| 152 | Phosphorylation | PVHKVGNTPLDMNQF CCCCCCCCCCCHHHH | 21.21 | 30257219 | |
| 156 | Sulfoxidation | VGNTPLDMNQFRMLF CCCCCCCHHHHHHHH | 5.82 | 21406390 | |
| 167 | Ubiquitination | RMLFSTCKVPGITRD HHHHHHCCCCCCCHH | 52.10 | - | |
| 358 | Acetylation | GRWKGSEKVRDIPLP CCCCCCCCCCCCCCC | 44.24 | 23749302 | |
| 392 | Phosphorylation | AQYLREASDLQIAAY HHHHHHCCHHHHHHH | 33.82 | 28188228 | |
| 402 | Phosphorylation | QIAAYAFTSFGKKLT HHHHHHHHHHHHHCC | 18.25 | 28188228 | |
| 403 | Phosphorylation | IAAYAFTSFGKKLTK HHHHHHHHHHHHCCC | 26.08 | 28188228 | |
| 406 | Succinylation | YAFTSFGKKLTKNKM HHHHHHHHHCCCCCC | 42.47 | - | |
| 406 | Acetylation | YAFTSFGKKLTKNKM HHHHHHHHHCCCCCC | 42.47 | - | |
| 406 | Succinylation | YAFTSFGKKLTKNKM HHHHHHHHHCCCCCC | 42.47 | - | |
| 409 | Phosphorylation | TSFGKKLTKNKMLHP HHHHHHCCCCCCCCH | 41.26 | 21214269 | |
| 428 | Phosphorylation | QLALQLAYYRLHGHP HHHHHHHHHHHHCCC | 9.56 | 21214269 | |
| 429 | Phosphorylation | LALQLAYYRLHGHPG HHHHHHHHHHHCCCC | 10.90 | 21214269 | |
| 482 | Acetylation | NLRERQQKMLQAFAK CHHHHHHHHHHHHHH | 32.99 | 25953088 | |
| 495 | Acetylation | AKHNKMMKDCSAGKG HHHCHHHHHCCCCCC | 52.68 | 25953088 | |
| 531 | Phosphorylation | LFTDPLFSKSGGGGN HHCCCCCCCCCCCCC | 33.33 | 24719451 | |
| 533 | Phosphorylation | TDPLFSKSGGGGNFV CCCCCCCCCCCCCCE | 41.28 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OCTC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OCTC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OCTC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| INT14_HUMAN | VWA9 | physical | 26186194 | |
| E2AK4_HUMAN | EIF2AK4 | physical | 26186194 | |
| KLDC4_HUMAN | KLHDC4 | physical | 26186194 | |
| UBP25_HUMAN | USP25 | physical | 26186194 | |
| KLDC4_HUMAN | KLHDC4 | physical | 28514442 | |
| UBP25_HUMAN | USP25 | physical | 28514442 | |
| F16P1_HUMAN | FBP1 | physical | 28514442 | |
| E2AK4_HUMAN | EIF2AK4 | physical | 28514442 | |
| P66B_HUMAN | GATAD2B | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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