NPHN_HUMAN - dbPTM
NPHN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NPHN_HUMAN
UniProt AC O60500
Protein Name Nephrin
Gene Name NPHS1
Organism Homo sapiens (Human).
Sequence Length 1241
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.
Protein Description Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity)..
Protein Sequence MALGTTLRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGISEKTEAGSEEDRVRNEYEESQWTGERDTQSSTVSTTEAEPYYRSLRDFSPQLPPTQEEVSYSRGFTGEDEDMAFPGHLYDEVERTYPPSGAWGPLYDEVQMGPWDLHWPEDTYQDPRGIYDQVAGDLDTLEPDSLPFELRGHLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationAQLAIPASVPRGFWA
HHHCCCCCCCCCEEC		27.5724719451
40N-linked_GlycosylationGFWALPENLTVVEGA
CEECCCCCEEEECCC		38.79UniProtKB CARBOHYD
291PhosphorylationPVSTAWGTEHTQAVA
CCCCCCCCHHHHHHH		17.5629978859
294PhosphorylationTAWGTEHTQAVARSV
CCCCCHHHHHHHEEE		16.4029978859
300PhosphorylationHTQAVARSVLVMTVR
HHHHHHEEEEEEEEC		15.2929978859
305PhosphorylationARSVLVMTVRPEDHG
HEEEEEEEECHHHCC		13.0929978859
356N-linked_GlycosylationASQTENKNVTLSCVS
CCCCCCCCEEEEEEC		43.52UniProtKB CARBOHYD
401N-linked_GlycosylationGGHISMSNLTFLARR
CCCEECCCEEEEEEE		34.16UniProtKB CARBOHYD
414PhosphorylationRREDNGLTLTCEAFS
EECCCCEEEEEHHHH		22.78-
416PhosphorylationEDNGLTLTCEAFSEA
CCCCEEEEEHHHHHH		11.76-
421PhosphorylationTLTCEAFSEAFTKET
EEEEHHHHHHHCHHH		34.75-
432PhosphorylationTKETFKKSLILNVKY
CHHHHHHHEEEEEEC		22.6422817900
439PhosphorylationSLILNVKYPAQKLWI
HEEEEEECCCCEEEE		10.26-
547N-linked_GlycosylationAVQFPPTNVTILANA
EECCCCCCEEEEECC		34.41UniProtKB CARBOHYD
553N-linked_GlycosylationTNVTILANASALRPG
CCEEEEECCCCCCCC		30.86UniProtKB CARBOHYD
564N-linked_GlycosylationLRPGDALNLTCVSVS
CCCCCCEEEEEEECC		34.72UniProtKB CARBOHYD
577N-linked_GlycosylationVSSNPPVNLSWDKEG
CCCCCCCCCCCCCCC		33.85UniProtKB CARBOHYD
633PhosphorylationHSAELRETVSSFYRL
ECHHHHHHHHHHHHC		21.1829083192
635PhosphorylationAELRETVSSFYRLNV
HHHHHHHHHHHHCCE		23.3429083192
636PhosphorylationELRETVSSFYRLNVL
HHHHHHHHHHHCCEE		23.2029083192
638PhosphorylationRETVSSFYRLNVLYR
HHHHHHHHHCCEEEC		19.0129083192
680N-linked_GlycosylationNPAPEAFNWTFRGYR
CCCCCCCCCEECEEC		43.88UniProtKB CARBOHYD
700PhosphorylationGPRHRILSSGALHLW
CCCEEEECCCCEEEE		25.10-
701PhosphorylationPRHRILSSGALHLWN
CCEEEECCCCEEEEE		25.33-
708N-linked_GlycosylationSGALHLWNVTRADDG
CCCEEEEEEEECCCC		31.48UniProtKB CARBOHYD
710PhosphorylationALHLWNVTRADDGLY
CEEEEEEEECCCCEE		19.54-
908N-linked_GlycosylationSSLLTIANVSAAQDY
HHHEEEECCCCCCCC		25.15UniProtKB CARBOHYD
939PhosphorylationNIQLVSISRPDPPSG
EEEEEEECCCCCCCC		30.1924719451
1029 (in isoform 2)Phosphorylation-32.4528634298
1034 (in isoform 2)Phosphorylation-25.6228634298
1035 (in isoform 2)Phosphorylation-18.9728634298
1042 (in isoform 2)Phosphorylation-49.5828634298
1051 (in isoform 2)Phosphorylation-70.4928634298
1055 (in isoform 2)Phosphorylation-74.2328634298
1058 (in isoform 2)Phosphorylation-57.3928634298
1098PhosphorylationRRLAEGISEKTEAGS
HHHHHHHHHHCCCCC		43.85-
1101PhosphorylationAEGISEKTEAGSEED
HHHHHHHCCCCCHHH		27.3228857561
1105PhosphorylationSEKTEAGSEEDRVRN
HHHCCCCCHHHHHHH		44.8828857561
1120PhosphorylationEYEESQWTGERDTQS
HHHHHHCCCCCCCCC		22.8721321125
1125PhosphorylationQWTGERDTQSSTVST
HCCCCCCCCCCEEEC		36.2521321125
1176PhosphorylationMAFPGHLYDEVERTY
CCCCCCHHHHHHHHC		12.3722718751
1193PhosphorylationSGAWGPLYDEVQMGP
CCCCCCCCCCCCCCC		17.1219882202
1217PhosphorylationYQDPRGIYDQVAGDL
CCCCCCHHHHHCCCC		11.8019882202
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1120TPhosphorylationKinasePRKCAP17252
GPS
1125TPhosphorylationKinasePRKCAP17252
GPS
1193YPhosphorylationKinaseFYNP06241
Uniprot
1193YPhosphorylationKinaseYESP07947
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NPHN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NPHN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FYN_HUMANFYNphysical
12846735
YES_HUMANYES1physical
12668668
FYN_HUMANFYNphysical
12668668
NPHN_HUMANNPHS1physical
12660326
PODO_MOUSENphs2physical
11562357
CDC42_MOUSECdc42genetic
11562357
RAC1_MOUSERac1genetic
11562357
RHOA_MOUSERhoagenetic
11562357
MP2K4_HUMANMAP2K4genetic
11562357
MP2K3_HUMANMAP2K3genetic
11562357
MP2K6_HUMANMAP2K6genetic
11562357
SH3K1_HUMANSH3KBP1physical
20457601
CD2AP_HUMANCD2APphysical
20457601
CALX_HUMANCANXphysical
24303155
IQGA1_HUMANIQGAP1physical
25652011
Drug and Disease Associations
Kegg Disease
H00626 Nephrotic syndrome and focal segmental glomerulosclerosis
OMIM Disease
256300Nephrotic syndrome 1 (NPHS1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NPHN_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, AND MASSSPECTROMETRY.

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