dbPTM

PODO_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PODO_MOUSE
UniProt AC	Q91X05
Protein Name	Podocin
Gene Name	Nphs2
Organism	Mus musculus (Mouse).
Sequence Length	385
Subcellular Localization	Membrane Single-pass membrane protein .
Protein Description	Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton..
Protein Sequence	MDSRARSSSREAHGRSSRSSSRDDKKAKAGRGSRGRARPDAGAERQSTGRTATRGEPRAPAATATVVDVDEVRGPGEEGTEVVALLESERPEEGIKPSGLGACEWLLVLASLIFIIMTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRSLTEILLERKSIAQDVKVALDAVTCIWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAAEGEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTEKPATVVLPLPFDMLSLLSSPGNRAQGSINYPSSSKPVEPLNPKKKDSPML

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	S-palmitoylation	KPSGLGACEWLLVLA CCCCCCHHHHHHHHH	3.51	-
301	Ubiquitination	VIAAEGEKAASESLR EEEECHHHHHHHHHH	61.17	-
362	Phosphorylation	PGNRAQGSINYPSSS CCCCCCCCCCCCCCC	8.79	21082442
370	Ubiquitination	INYPSSSKPVEPLNP CCCCCCCCCCCCCCC	55.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PODO_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PODO_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PODO_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPHN_HUMAN	NPHS1	genetic	11562357
NPHN_HUMAN	NPHS1	physical	11562357
TRPC6_MOUSE	Trpc6	physical	23657570
PODO_MOUSE	Nphs2	physical	26792178
TGFR2_MOUSE	Tgfbr2	physical	26792178
IFM3_MOUSE	Ifitm3	physical	26792178
EPHA2_MOUSE	Epha2	physical	26792178
NOTC2_MOUSE	Notch2	physical	26792178
PTPRF_MOUSE	Ptprf	physical	26792178
UFO_MOUSE	Axl	physical	26792178
IRGM1_MOUSE	Irgm1	physical	26792178
HA1B_MOUSE	H2-K1	physical	26792178
KIRR1_MOUSE	Kirrel	physical	26792178
STEA2_MOUSE	Steap2	physical	26792178
PLXB2_MOUSE	Plxnb2	physical	26792178
MYOF_MOUSE	Myof	physical	26792178
PTPRK_MOUSE	Ptprk	physical	26792178
TFR1_MOUSE	Tfrc	physical	26792178
AT2A2_MOUSE	Atp2a2	physical	26792178
UNC5B_MOUSE	Unc5b	physical	26792178
LBR_MOUSE	Lbr	physical	26792178
DNJB6_MOUSE	Dnajb6	physical	26792178
ADT1_MOUSE	Slc25a4	physical	26792178
IGF1R_MOUSE	Igf1r	physical	26792178
T176B_MOUSE	Tmem176b	physical	26792178
ARF4_MOUSE	Arf4	physical	26792178
ERBB2_MOUSE	Erbb2	physical	26792178
S20A1_MOUSE	Slc20a1	physical	26792178
BAG2_MOUSE	Bag2	physical	26792178
ATPG_MOUSE	Atp5c1	physical	26792178
UBR4_MOUSE	Ubr4	physical	26792178
ADT2_MOUSE	Slc25a5	physical	26792178
SCMC1_MOUSE	Slc25a24	physical	26792178
RS18_MOUSE	Rps18	physical	26792178
ERLN2_MOUSE	Erlin2	physical	26792178
RS3_MOUSE	Rps3	physical	26792178
VAPA_MOUSE	Vapa	physical	26792178
IPYR2_MOUSE	Ppa2	physical	26792178
SEPT9_MOUSE	Sept9	physical	26792178
DCTN2_MOUSE	Dctn2	physical	26792178
BICD2_MOUSE	Bicd2	physical	26792178
DCTN3_MOUSE	Dctn3	physical	26792178
NEK9_MOUSE	Nek9	physical	26792178
VAC14_MOUSE	Vac14	physical	26792178
PKD2_MOUSE	Pkd2	physical	26792178
MAAI_MOUSE	Gstz1	physical	26792178
IPYR_MOUSE	Ppa1	physical	26792178
ITM2B_MOUSE	Itm2b	physical	26792178
AKAP1_MOUSE	Akap1	physical	26792178
NPHN_MOUSE	Nphs1	physical	26792178
NDUA4_MOUSE	Ndufa4	physical	26792178
TBB2B_MOUSE	Tubb2b	physical	26792178
CMC1_MOUSE	Slc25a12	physical	26792178
EFTU_MOUSE	Tufm	physical	26792178
DIC_MOUSE	Slc25a10	physical	26792178
RHPN1_MOUSE	Rhpn1	physical	26792178
SEP11_MOUSE	Sept11	physical	26792178
DLDH_MOUSE	Dld	physical	26792178
ATPO_MOUSE	Atp5o	physical	26792178
KANK2_MOUSE	Kank2	physical	26792178
CMC2_MOUSE	Slc25a13	physical	26792178

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PODO_MOUSE

Related Literatures of Post-Translational Modification