IPYR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IPYR2_MOUSE
• UniProt AC: Q91VM9
• Protein Name: Inorganic pyrophosphatase 2, mitochondrial
• Gene Name: Ppa2
• Organism: Mus musculus (Mouse).
• Sequence Length: 330
• Subcellular Localization: Mitochondrion .
• Protein Description: Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function..
• Protein Sequence: MRALLPLLSVGRGWRVGAAARPPRRVMSLYRTEELGHPRSQDYRLFFKHVAGHYISPFHDIPLKADCKEEHDIPRKKARNDEYENLFNMVVEIPRWTNAKMEIATEEPLNPIKQDIKNGKLRYTPNIFPHKGYIWNYGALPQTWEDPHLRDKSTDCCGDNDPIDVCEIGSKVLSRGDVVHVKILGTLALIDQSETDWKIIAINVNDPEAEKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENKFAFNGEFKNKAFALDVINSAHERWKEMVMKKCDKGAISCVNVHICDSPFHCTMEEARSLVESVPTPSMNKESNVEEEVWHFLRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Acetylation	PFHDIPLKADCKEEH CCCCCCCCCCCCCCC	36.50	23576753
67	S-nitrosylation	DIPLKADCKEEHDIP CCCCCCCCCCCCCCC	7.74	21278135
67	S-nitrosocysteine	DIPLKADCKEEHDIP CCCCCCCCCCCCCCC	7.74	-
68	Succinylation	IPLKADCKEEHDIPR CCCCCCCCCCCCCCC	67.68	23806337
68	Acetylation	IPLKADCKEEHDIPR CCCCCCCCCCCCCCC	67.68	23806337
100	Succinylation	IPRWTNAKMEIATEE CCCCCCCCCEECCCC	38.85	23806337
100	Acetylation	IPRWTNAKMEIATEE CCCCCCCCCEECCCC	38.85	23806337
152	Acetylation	EDPHLRDKSTDCCGD CCCCCCCCCCCCCCC	49.15	23864654
171	Acetylation	DVCEIGSKVLSRGDV CHHHCCCEECCCCCE	41.82	23864654
211	Acetylation	VNDPEAEKFHDIDDV CCCHHHHHCCCCCHH	55.86	23864654
211	Succinylation	VNDPEAEKFHDIDDV CCCHHHHHCCCCCHH	55.86	23806337
211	Succinylation	VNDPEAEKFHDIDDV CCCHHHHHCCCCCHH	55.86	-
219	Acetylation	FHDIDDVKKFKPGYL CCCCCHHHHCCCCHH	60.53	23576753
219	Succinylation	FHDIDDVKKFKPGYL CCCCCHHHHCCCCHH	60.53	23806337
220	Acetylation	HDIDDVKKFKPGYLE CCCCHHHHCCCCHHH	59.47	23806337
220	Succinylation	HDIDDVKKFKPGYLE CCCCHHHHCCCCHHH	59.47	23806337
222	Succinylation	IDDVKKFKPGYLEAT CCHHHHCCCCHHHEE	46.54	23806337
222	Acetylation	IDDVKKFKPGYLEAT CCHHHHCCCCHHHEE	46.54	23806337
236	Phosphorylation	TLNWFRLYKVPDGKP EEEEEEEEECCCCCC	12.99	-
237	Acetylation	LNWFRLYKVPDGKPE EEEEEEEECCCCCCC	52.46	23201123
242	Acetylation	LYKVPDGKPENKFAF EEECCCCCCCCCCCC	57.44	23806337
242	Succinylation	LYKVPDGKPENKFAF EEECCCCCCCCCCCC	57.44	23806337
246	Succinylation	PDGKPENKFAFNGEF CCCCCCCCCCCCCEE	36.09	23806337
246	Acetylation	PDGKPENKFAFNGEF CCCCCCCCCCCCCEE	36.09	23806337
254	Succinylation	FAFNGEFKNKAFALD CCCCCEECCHHHHHH	53.92	-
254	Succinylation	FAFNGEFKNKAFALD CCCCCEECCHHHHHH	53.92	23806337
254	Acetylation	FAFNGEFKNKAFALD CCCCCEECCHHHHHH	53.92	23806337
256	Acetylation	FNGEFKNKAFALDVI CCCEECCHHHHHHHH	45.53	23576753
256	Succinylation	FNGEFKNKAFALDVI CCCEECCHHHHHHHH	45.53	23806337
271	Succinylation	NSAHERWKEMVMKKC HHHHHHHHHHHHHHC	42.00	23954790
271	Acetylation	NSAHERWKEMVMKKC HHHHHHHHHHHHHHC	42.00	23864654
316	Succinylation	VPTPSMNKESNVEEE CCCCCCCCCCCHHHH	54.61	23806337
316	Acetylation	VPTPSMNKESNVEEE CCCCCCCCCCCHHHH	54.61	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IPYR2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IPYR2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IPYR2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IPYR2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.