CMC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CMC1_MOUSE
• UniProt AC: Q8BH59
• Protein Name: Calcium-binding mitochondrial carrier protein Aralar1
• Gene Name: Slc25a12
• Organism: Mus musculus (Mouse).
• Sequence Length: 677
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle..
• Protein Sequence: MAVKVHTTKRGDPHELRNIFLQYASTEVDGEHYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYVEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDVMVTIRSHMLTPFVEENLVSAAGGGTSHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDIEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGTGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTKRDGSIPLPAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLQDLGLFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGRVGGINLLTAGALAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVVDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPSGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVAQPKAAAAAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVKVHTTK ------CCEEEEECC	15.16	-
4	Malonylation	----MAVKVHTTKRG ----CCEEEEECCCC	20.82	26320211
55	Ubiquitination	NDPNSNPKIVQLLAG CCCCCCHHHHHHHHH	60.81	22790023
101	Phosphorylation	AFQLFDKSGNGEVTF EEEEECCCCCCCEEE	39.06	22210690
178	Phosphorylation	KSKSGMISGLDFSDV CCCCCCCCCCCHHHH	25.14	28285833
242	Phosphorylation	IYSTLAGTRKDIEVT HHHHHCCCCCCEEEC	29.01	28464351
278	Phosphorylation	LYQLADLYNASGRLT HHHHHHHHCCCCCEE	14.83	29899451
302	Nitration	LAEGALPYNLAELQR HCCCCCCCCHHHHHH	24.53	-
312	Phosphorylation	AELQRQQSPGLGRPI HHHHHHCCCCCCCCH	16.76	28464351
351	Succinylation	VYPIDLVKTRMQNQR EEEHHHHHHHHHCCC	37.40	24315375
351	Acetylation	VYPIDLVKTRMQNQR EEEHHHHHHHHHCCC	37.40	23576753
362	Phosphorylation	QNQRGTGSVVGELMY HCCCCCCCHHHHHHH	17.29	28464351
375	S-nitrosylation	MYKNSFDCFKKVLRY HHHCCHHHHHHHHHH	5.19	21278135
375	S-nitrosocysteine	MYKNSFDCFKKVLRY HHHCCHHHHHHHHHH	5.19	-
377	Succinylation	KNSFDCFKKVLRYEG HCCHHHHHHHHHHHC	48.59	24315375
377	Acetylation	KNSFDCFKKVLRYEG HCCHHHHHHHHHHHC	48.59	23864654
378	Acetylation	NSFDCFKKVLRYEGF CCHHHHHHHHHHHCC	26.67	23201123
382	Phosphorylation	CFKKVLRYEGFFGLY HHHHHHHHHCCHHHH	19.08	25195567
403	Acetylation	LIGVAPEKAIKLTVN HHCCCCHHHEEEEHH	55.12	23864654
406	Acetylation	VAPEKAIKLTVNDFV CCCHHHEEEEHHHHH	42.86	23576753
406	Malonylation	VAPEKAIKLTVNDFV CCCHHHEEEEHHHHH	42.86	26320211
406	Ubiquitination	VAPEKAIKLTVNDFV CCCHHHEEEEHHHHH	42.86	-
435	S-nitrosocysteine	AEILAGGCAGGSQVI HHHHCCCCCCCCEEE	2.88	-
435	S-nitrosylation	AEILAGGCAGGSQVI HHHHCCCCCCCCEEE	2.88	21278135
462	Phosphorylation	QVAGEITTGPRVSAL EECCCCCCCCCCCHH	51.34	28059163
482	Acetylation	LGLFGLYKGAKACFL HCCCCHHCCCCEEEC	58.39	23954790
485	Acetylation	FGLYKGAKACFLRDI CCHHCCCCEEECCCC	55.12	23201123
486	Ubiquitination	GLYKGAKACFLRDIP CHHCCCCEEECCCCC	6.69	27667366
487	S-nitrosylation	LYKGAKACFLRDIPF HHCCCCEEECCCCCC	3.04	21278135
487	S-nitrosocysteine	LYKGAKACFLRDIPF HHCCCCEEECCCCCC	3.04	-
543	Acetylation	VTPADVIKTRLQVAA CCHHHHHHHHHHHHH	27.69	23576753
563	S-nitrosylation	TYSGVVDCFRKILRE CHHHHHHHHHHHHHH	2.10	21278135
563	S-nitrosocysteine	TYSGVVDCFRKILRE CHHHHHHHHHHHHHH	2.10	-
572	Ubiquitination	RKILREEGPSAFWKG HHHHHHHCCCHHHCC	19.40	27667366
578	Acetylation	EGPSAFWKGTAARVF HCCCHHHCCHHHHHH	39.67	24062335
606	Phosphorylation	ELLQRWFYIDFGGLK HHHHHCCCCCCCCCC	7.82	-
661	Ubiquitination	GLYLPKFKSPSVAVA CEECCCCCCCCEEEC	68.53	27667366
662	Phosphorylation	LYLPKFKSPSVAVAQ EECCCCCCCCEEECC	26.07	28542873
664	Phosphorylation	LPKFKSPSVAVAQPK CCCCCCCCEEECCHH	29.78	28542873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CMC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CMC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CMC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CMC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.