S20A1_MOUSE - dbPTM
S20A1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S20A1_MOUSE
UniProt AC Q61609
Protein Name Sodium-dependent phosphate transporter 1
Gene Name Slc20a1
Organism Mus musculus (Mouse).
Sequence Length 681
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification.; (Microbial infection) May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B)..
Protein Sequence MESTVATITSTLAAVTASAPPKYDNLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSALLGAKVSETIRNGLIDVELYNETQDLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVANGQKGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILRKADPVPNGLRALPIFYACTIGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREVKSSPSESPLMEKKSNLKEDHEETKMAPGDVEHRNPVSEVVCATGPLRAVVEERTVSFKLGDLEEAPERERLPMDLKEETSIDSTINGAVQLPNGNLVQFSQTVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGDEMETLTWPNADTKKRIRMDSYTSYCNAVSDLHSESEMDMSVKAEMGLGDRKGSSGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYKQEASTKAATPIWLLLYGGVGICMGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAVFKYIILPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MESTVATITST
----CCCHHHHHHHH		10.8021454597
18PhosphorylationTLAAVTASAPPKYDN
HHHHHHCCCCCCCCH		31.7621454597
49UbiquitinationSVGANDVANSFGTAV
HHCCHHHHHHHHCCC		14.6027667366
67UbiquitinationVVTLKQACILASIFE
CEEHHHHHHHHHHHH		2.1327667366
117UbiquitinationSVSAMFGSAVWQLVA
HHHHHHHHHHHHHHH		14.3727667366
135UbiquitinationKLPISGTHCIVGATI
CCCCCCCEEEEECEE		11.6627667366
268PhosphorylationKIEREVKSSPSESPL
HHHHHHHCCCCCCCH		53.2925521595
269PhosphorylationIEREVKSSPSESPLM
HHHHHHCCCCCCCHH		27.0825521595
271PhosphorylationREVKSSPSESPLMEK
HHHHCCCCCCCHHHC		53.2925521595
273PhosphorylationVKSSPSESPLMEKKS
HHCCCCCCCHHHCCC		27.8925521595
278AcetylationSESPLMEKKSNLKED
CCCCHHHCCCCCCCC		47.766567123
289PhosphorylationLKEDHEETKMAPGDV
CCCCHHHHCCCCCCC		24.1228418008
322PhosphorylationVVEERTVSFKLGDLE
HEEEEEEEEECCCHH		18.9525338131
324UbiquitinationEERTVSFKLGDLEEA
EEEEEEEECCCHHHC		44.0122790023
391PhosphorylationVHKDSGLYKELLHKL
EECCCCHHHHHHHHH		13.1225159016
392UbiquitinationHKDSGLYKELLHKLH
ECCCCHHHHHHHHHH		47.1022790023
420PhosphorylationKPLRRNNSYTSYTMA
CCCCCCCCCCCEEEE		33.0826824392
421PhosphorylationPLRRNNSYTSYTMAI
CCCCCCCCCCEEEEE		11.2226643407
422PhosphorylationLRRNNSYTSYTMAIC
CCCCCCCCCEEEEEC		18.3225266776
423PhosphorylationRRNNSYTSYTMAICG
CCCCCCCCEEEEECC		15.4623649490
424PhosphorylationRNNSYTSYTMAICGM
CCCCCCCEEEEECCC		7.8526643407
425PhosphorylationNNSYTSYTMAICGMP
CCCCCCEEEEECCCC		10.4123649490
466PhosphorylationKKRIRMDSYTSYCNA
CCEECHHHHHHHHHH		22.4423608596
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S20A1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S20A1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S20A1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBP7_MOUSEUsp7physical
27568561
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S20A1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268; SER-269 ANDSER-273, AND MASS SPECTROMETRY.
"Proteomic analysis of in vivo phosphorylated synaptic proteins.";
Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.;
J. Biol. Chem. 280:5972-5982(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269 AND SER-273, ANDMASS SPECTROMETRY.

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