UBP7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP7_MOUSE
• UniProt AC: Q6A4J8
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 7
• Gene Name: Usp7
• Organism: Mus musculus (Mouse).
• Sequence Length: 1103
• Subcellular Localization: Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucl
• Protein Description: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E and DAXX. [PubMed: 21268065]
• Protein Sequence: MNHQQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVTLSDGHSNAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDDKSFSRRISHLFFHEENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKDVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVRYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGDKASGRLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLITVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Phosphorylation	-	36.16	22006019
19	Phosphorylation	KAGEQQLSEPEDMEM HHHHHHCCCHHHCCC	46.93	25521595
31	Phosphorylation	MEMEAGDTDDPPRIT CCCCCCCCCCCCCCC	41.19	25619855
38	Phosphorylation	TDDPPRITQNPVING CCCCCCCCCCCEECC	24.47	25619855
48	Phosphorylation	PVINGNVTLSDGHSN CEECCEEEECCCCCC	25.25	25619855
50	Phosphorylation	INGNVTLSDGHSNAE ECCEEEECCCCCCCC	31.98	25619855
54	Phosphorylation	VTLSDGHSNAEEDME EEECCCCCCCCHHCC	43.17	25619855
64	Phosphorylation	EEDMEDDTSWRSEAT CHHCCCCCCCCCCEE	42.38	25619855
65	Phosphorylation	EDMEDDTSWRSEATF HHCCCCCCCCCCEEE	27.73	25619855
156	Phosphorylation	KSFSRRISHLFFHEE CCHHHHHHHHHCCCC	16.60	20139300
175	Phosphorylation	FSNFMAWSEVTDPEK CCCEECCCCCCCHHC	16.79	-
178	Phosphorylation	FMAWSEVTDPEKGFI EECCCCCCCHHCCCC	41.61	-
255	Ubiquitination	TEGDDSSKSVPLALQ CCCCCCCCCHHHHHH	60.47	-
256	Phosphorylation	EGDDSSKSVPLALQR CCCCCCCCHHHHHHH	30.80	28059163
315	Phosphorylation	VENKMKGTCVEGTIP CCHHCCCCCEECCCH	14.09	28542873
323	Ubiquitination	CVEGTIPKLFRGKMV CEECCCHHHHCCCEE	57.30	-
328	Malonylation	IPKLFRGKMVSYIQC CHHHHCCCEEEEEEE	31.69	26320211
356	Ubiquitination	YDIQLSIKGKKNIFE EEEEEEECCCCCHHH	62.39	-
398	Phosphorylation	EKGVKFLTLPPVLHL HHCCCEEECCCHHHH	40.11	20139300
421	Ubiquitination	PQTDQNIKINDRFEF CCCCCCCEECCCCCC	42.90	-
440	Ubiquitination	PLDEFLQKTDPKDPA CHHHHHHHCCCCCHH	57.98	-
512	Phosphorylation	DLSVRHCTNAYMLVY CCHHHHHCCEEEEEE	19.43	21183079
519	Phosphorylation	TNAYMLVYIRESKLS CCEEEEEEEEHHHHH	7.12	21183079
523	Phosphorylation	MLVYIRESKLSEVLQ EEEEEEHHHHHHHHH	29.11	21183079
753	Phosphorylation	RIQDYDVSLDKALDE HHHHCCCCHHHHHHH	28.14	29899451
825	Ubiquitination	MNYFQVAKTVAQRLN CCHHHHHHHHHHHHC	44.68	-
825	Acetylation	MNYFQVAKTVAQRLN CCHHHHHHHHHHHHC	44.68	22826441
843	Phosphorylation	MLLQFFKSQGYRDGP HHHHHHHHCCCCCCC	24.55	-
846	Phosphorylation	QFFKSQGYRDGPGNP HHHHHCCCCCCCCCC	9.63	-
870	Ubiquitination	RDLLQFFKPRQPKKL HHHHHHHCCCCCCCH	40.35	-
870	Acetylation	RDLLQFFKPRQPKKL HHHHHHHCCCCCCCH	40.35	22826441
878	Phosphorylation	PRQPKKLYYQQLKMK CCCCCCHHHHHHHHH	14.22	-
879	Phosphorylation	RQPKKLYYQQLKMKI CCCCCHHHHHHHHHC	10.54	-
883	Ubiquitination	KLYYQQLKMKITDFE CHHHHHHHHHCCCCC	33.53	-
894	Phosphorylation	TDFENRRSFKCIWLN CCCCCCCCEEEEEEC	26.31	25338131
962	Glutathionylation	QEDELLECLSPATSR CCCHHHHHCCCCCCC	4.62	24333276
964	Phosphorylation	DELLECLSPATSRTF CHHHHHCCCCCCCEE	24.93	26745281
967	Phosphorylation	LECLSPATSRTFRIE HHHCCCCCCCEEEEE	23.33	23984901
968	Phosphorylation	ECLSPATSRTFRIEE HHCCCCCCCEEEEEE	31.28	23984901
1027	Phosphorylation	EVMKRIQSLLDIQEK HHHHHHHHHHHHCHH	28.64	25521595
1085	Acetylation	LGLDHFNKAPKRSRY CCCCCCCCCCCCHHH	66.19	23806337
1093	Phosphorylation	APKRSRYTYLEKAIK CCCCHHHHHHHHHHH	22.11	29176673
1097	Acetylation	SRYTYLEKAIKIHN- HHHHHHHHHHHCCC-	53.46	-
1097	Ubiquitination	SRYTYLEKAIKIHN- HHHHHHHHHHHCCC-	53.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP7_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
870	K	ubiquitylation	Ubiquitinated at Lys-870 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM2_MOUSE	Mdm2	physical	20697359
MDM4_MOUSE	Mdm4	physical	20697359
IRS1_MOUSE	Irs1	physical	27568561
PTEN_MOUSE	Pten	physical	27568561

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND MASSSPECTROMETRY.
PubMed: 19144319