dbPTM

IRS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IRS1_MOUSE
UniProt AC	P35569
Protein Name	Insulin receptor substrate 1
Gene Name	Irs1
Organism	Mus musculus (Mouse).
Sequence Length	1233
Subcellular Localization
Protein Description	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity)..
Protein Sequence	MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSLTHPHHHVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCPPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRIGPAPPGSATVCRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKASLPRPTGAAPPPSSTASSSASVTPQGATAEQATHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAGNTVPFGAGAAVGGSGGGGGGGSEDVKRHSSASFENVWLRPGDLGGVSKESAPVCGAAGGLEKSLNYIDLDLAKEHSQDCPSQQQSLPPPPPHQPLGSNEGNSPRRSSEDLSNYASISFQKQPEDRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASPPDTDGF -----CCCCCCCCCC	49.15	26824392
7	Phosphorylation	-MASPPDTDGFSDVR -CCCCCCCCCCCCCC	43.74	25619855
11	Phosphorylation	PPDTDGFSDVRKVGY CCCCCCCCCCCCCCE	40.50	25619855
46	Phosphorylation	GGPARLEYYENEKKW CCCCCCEEECCCCCC	22.22	22817900
47	Phosphorylation	GPARLEYYENEKKWR CCCCCEEECCCCCCC	11.69	-
99	Phosphorylation	HFAIAADSEAEQDSW CEEEECCCHHHHCHH	33.70	-
131	Phosphorylation	AGGGCGGSCSGSSGV CCCCCCCCCCCCCCC	7.15	-
147	Phosphorylation	EAGEDLSYDTGPGPA CCCCCCCCCCCCCHH	25.48	-
263	Phosphorylation	SDEFRPRSKSQSSSS CCCCCCCCCCCCCCC	39.06	25619855
265	Phosphorylation	EFRPRSKSQSSSSCS CCCCCCCCCCCCCCC	36.22	25521595
267	Phosphorylation	RPRSKSQSSSSCSNP CCCCCCCCCCCCCCC	39.00	25168779
268	Phosphorylation	PRSKSQSSSSCSNPI CCCCCCCCCCCCCCC	20.73	25619855
269	Phosphorylation	RSKSQSSSSCSNPIS CCCCCCCCCCCCCCC	40.38	25619855
270	Phosphorylation	SKSQSSSSCSNPISV CCCCCCCCCCCCCCC	24.42	25619855
272	Phosphorylation	SQSSSSCSNPISVPL CCCCCCCCCCCCCCC	47.81	25619855
290	Phosphorylation	HLNNPPPSQVGLTRR HCCCCCHHHCCCCCC	43.18	29514104
298	Phosphorylation	QVGLTRRSRTESITA HCCCCCCCCCCCEEE	40.02	26160508
300	Phosphorylation	GLTRRSRTESITATS CCCCCCCCCCEEECC	35.02	26160508
302	Phosphorylation	TRRSRTESITATSPA CCCCCCCCEEECCCH	25.32	17050683
304	Phosphorylation	RSRTESITATSPASM CCCCCCEEECCCHHH	32.91	24453211
306	Phosphorylation	RTESITATSPASMVG CCCCEEECCCHHHHC	26.96	24453211
307	Phosphorylation	TESITATSPASMVGG CCCEEECCCHHHHCC	18.92	14556646
310	Phosphorylation	ITATSPASMVGGKPG EEECCCHHHHCCCCC	19.86	26160508
315	Acetylation	PASMVGGKPGSFRVR CHHHHCCCCCEEEEE	40.03	22826441
318	Phosphorylation	MVGGKPGSFRVRASS HHCCCCCEEEEEECC	20.57	23684622
324	Phosphorylation	GSFRVRASSDGEGTM CEEEEEECCCCCCCC	20.56	25521595
325	Phosphorylation	SFRVRASSDGEGTMS EEEEEECCCCCCCCC	48.96	27087446
330	Phosphorylation	ASSDGEGTMSRPASV ECCCCCCCCCCCCCC	13.99	25619855
331	Oxidation	SSDGEGTMSRPASVD CCCCCCCCCCCCCCC	4.74	17242355
332	Phosphorylation	SDGEGTMSRPASVDG CCCCCCCCCCCCCCC	34.64	25619855
336	Phosphorylation	GTMSRPASVDGSPVS CCCCCCCCCCCCCCC	24.35	25619855
340	Phosphorylation	RPASVDGSPVSPSTN CCCCCCCCCCCCCCC	20.05	27742792
343	Phosphorylation	SVDGSPVSPSTNRTH CCCCCCCCCCCCCCC	19.27	25521595
345	Phosphorylation	DGSPVSPSTNRTHAH CCCCCCCCCCCCCCC	30.70	27087446
346	Phosphorylation	GSPVSPSTNRTHAHR CCCCCCCCCCCCCCC	31.91	27087446
367	Phosphorylation	LHPPLNHSRSIPMPS CCCCCCCCCCCCCCC	27.01	26643407
369	Phosphorylation	PPLNHSRSIPMPSSR CCCCCCCCCCCCCCC	33.77	26824392
374	Phosphorylation	SRSIPMPSSRCSPSA CCCCCCCCCCCCCCC	24.94	23737553
375	Phosphorylation	RSIPMPSSRCSPSAT CCCCCCCCCCCCCCC	31.28	23737553
378	Phosphorylation	PMPSSRCSPSATSPV CCCCCCCCCCCCCCC	22.30	25619855
380	Phosphorylation	PSSRCSPSATSPVSL CCCCCCCCCCCCCCC	28.08	25619855
382	Phosphorylation	SRCSPSATSPVSLSS CCCCCCCCCCCCCCC	37.59	25619855
383	Phosphorylation	RCSPSATSPVSLSSS CCCCCCCCCCCCCCC	24.03	25619855
386	Phosphorylation	PSATSPVSLSSSSTS CCCCCCCCCCCCCCC	26.39	25619855
388	Phosphorylation	ATSPVSLSSSSTSGH CCCCCCCCCCCCCCC	22.22	25619855
389	Phosphorylation	TSPVSLSSSSTSGHG CCCCCCCCCCCCCCC	33.33	25619855
390	Phosphorylation	SPVSLSSSSTSGHGS CCCCCCCCCCCCCCC	33.97	25619855
391	Phosphorylation	PVSLSSSSTSGHGST CCCCCCCCCCCCCCC	28.65	25619855
392	Phosphorylation	VSLSSSSTSGHGSTS CCCCCCCCCCCCCCC	40.45	25619855
393	Phosphorylation	SLSSSSTSGHGSTSD CCCCCCCCCCCCCCC	30.64	25619855
397	Phosphorylation	SSTSGHGSTSDCLFP CCCCCCCCCCCCCCC	21.04	25619855
398	Phosphorylation	STSGHGSTSDCLFPR CCCCCCCCCCCCCCC	32.93	25619855
399	Phosphorylation	TSGHGSTSDCLFPRR CCCCCCCCCCCCCCC	28.20	25619855
407	Phosphorylation	DCLFPRRSSASVSGS CCCCCCCCCCCCCCC	31.38	26160508
408	Phosphorylation	CLFPRRSSASVSGSP CCCCCCCCCCCCCCC	23.81	23684622
410	Phosphorylation	FPRRSSASVSGSPSD CCCCCCCCCCCCCCC	20.82	26525534
412	Phosphorylation	RRSSASVSGSPSDGG CCCCCCCCCCCCCCC	30.93	26160508
414	Phosphorylation	SSASVSGSPSDGGFI CCCCCCCCCCCCCCC	17.45	23684622
416	Phosphorylation	ASVSGSPSDGGFISS CCCCCCCCCCCCCCC	51.05	26160508
422	Phosphorylation	PSDGGFISSDEYGSS CCCCCCCCCCCCCCC	29.49	26525534
423	Phosphorylation	SDGGFISSDEYGSSP CCCCCCCCCCCCCCC	29.64	26525534
426	Phosphorylation	GFISSDEYGSSPCDF CCCCCCCCCCCCCCC	27.57	26525534
428	Phosphorylation	ISSDEYGSSPCDFRS CCCCCCCCCCCCCHH	30.15	26160508
429	Phosphorylation	SSDEYGSSPCDFRSS CCCCCCCCCCCCHHH	25.78	26160508
439	Phosphorylation	DFRSSFRSVTPDSLG CCHHHHHCCCHHHCC	28.47	25619855
441	Phosphorylation	RSSFRSVTPDSLGHT HHHHHCCCHHHCCCC	23.71	27742792
444	Phosphorylation	FRSVTPDSLGHTPPA HHCCCHHHCCCCCCC	37.14	25168779
448	Phosphorylation	TPDSLGHTPPARGEE CHHHCCCCCCCCCCH	29.21	27742792
458	Phosphorylation	ARGEEELSNYICMGG CCCCHHHHCCEECCC	30.76	24453211
460	Phosphorylation	GEEELSNYICMGGKG CCHHHHCCEECCCCC	7.66	26160508
478	Phosphorylation	LAAPNGHYILSRGGN CCCCCCEEEECCCCC	12.64	29514104
489	Phosphorylation	RGGNGHRYIPGANLG CCCCCCCCCCCCCCC	13.04	25619855
497	Phosphorylation	IPGANLGTSPALPGD CCCCCCCCCCCCCCC	34.40	25619855
498	Phosphorylation	PGANLGTSPALPGDE CCCCCCCCCCCCCCH	13.33	25619855
520	Phosphorylation	DNRFRKRTHSAGTSP CHHHHHHHHCCCCCC	24.18	23684622
522	Phosphorylation	RFRKRTHSAGTSPTI HHHHHHHCCCCCCCC	27.99	25521595
525	Phosphorylation	KRTHSAGTSPTISHQ HHHHCCCCCCCCCCC	31.11	26824392
526	Phosphorylation	RTHSAGTSPTISHQK HHHCCCCCCCCCCCC	21.09	25521595
528	Phosphorylation	HSAGTSPTISHQKTP HCCCCCCCCCCCCCC	34.57	27087446
530	Phosphorylation	AGTSPTISHQKTPSQ CCCCCCCCCCCCCCC	23.50	29472430
534	Phosphorylation	PTISHQKTPSQSSVA CCCCCCCCCCCCCCC	22.92	25338131
536	Phosphorylation	ISHQKTPSQSSVASI CCCCCCCCCCCCCCH	48.18	25338131
542	Phosphorylation	PSQSSVASIEEYTEM CCCCCCCCHHHHHHH	28.51	25338131
570	Phosphorylation	RLPGYRHSAFVPTHS CCCCCCCCCCCCCCC	17.88	26370283
575	Phosphorylation	RHSAFVPTHSYPEEG CCCCCCCCCCCCCCC	20.39	25338131
577	Phosphorylation	SAFVPTHSYPEEGLE CCCCCCCCCCCCCCC	44.88	25338131
578	Phosphorylation	AFVPTHSYPEEGLEM CCCCCCCCCCCCCCH	13.68	26060331
599	Phosphorylation	GGHHRPDTSNLHTDD CCCCCCCCCCCCCCC	23.38	22499769
600	Phosphorylation	GHHRPDTSNLHTDDG CCCCCCCCCCCCCCC	44.78	22499769
604	Phosphorylation	PDTSNLHTDDGYMPM CCCCCCCCCCCCCCC	38.66	22499769
608	Phosphorylation	NLHTDDGYMPMSPGV CCCCCCCCCCCCCCE	12.68	20116462
609	Oxidation	LHTDDGYMPMSPGVA CCCCCCCCCCCCCEE	2.48	17242355
612	Phosphorylation	DDGYMPMSPGVAPVP CCCCCCCCCCEECCC	16.78	16269459
620	Phosphorylation	PGVAPVPSNRKGNGD CCEECCCCCCCCCCC	49.88	22499769
628	Phosphorylation	NRKGNGDYMPMSPKS CCCCCCCCCCCCHHC	12.43	15143153
629	Oxidation	RKGNGDYMPMSPKSV CCCCCCCCCCCHHCC	2.40	17242355
631	Oxidation	GNGDYMPMSPKSVSA CCCCCCCCCHHCCCC	6.45	17242355
632	Phosphorylation	NGDYMPMSPKSVSAP CCCCCCCCHHCCCCC	24.25	27087446
635	Phosphorylation	YMPMSPKSVSAPQQI CCCCCHHCCCCCHHH	25.37	11287630
637	Phosphorylation	PMSPKSVSAPQQIIN CCCHHCCCCCHHHCC	41.12	23684622
658	Phosphorylation	QRVDPNGYMMMSPSG CCCCCCCCEEECCCC	6.62	25777480
662	Phosphorylation	PNGYMMMSPSGSCSP CCCCEEECCCCCCCC	9.68	22817900
664	Phosphorylation	GYMMMSPSGSCSPDI CCEEECCCCCCCCCC	35.71	25777480
666	Phosphorylation	MMMSPSGSCSPDIGG EEECCCCCCCCCCCC	18.76	25777480
668	Phosphorylation	MSPSGSCSPDIGGGS ECCCCCCCCCCCCCC	27.57	25777480
686	Phosphorylation	SSISAAPSGSSYGKP CCCCCCCCCCCCCCC	46.73	25777480
688	Phosphorylation	ISAAPSGSSYGKPWT CCCCCCCCCCCCCCC	25.40	25777480
689	Phosphorylation	SAAPSGSSYGKPWTN CCCCCCCCCCCCCCC	41.24	25777480
690	Phosphorylation	AAPSGSSYGKPWTNG CCCCCCCCCCCCCCC	30.76	25777480
731	Phosphorylation	TGDYMNMSPVGDSNT CCCCCCCCCCCCCCC	16.07	22817900
758	Phosphorylation	PQHKPVLSYYSLPRS CCCCCCEEEEECCCC	23.43	28066266
759	Phosphorylation	QHKPVLSYYSLPRSF CCCCCEEEEECCCCC	7.91	28066266
760	Phosphorylation	HKPVLSYYSLPRSFK CCCCEEEEECCCCCC	10.60	28066266
761	Phosphorylation	KPVLSYYSLPRSFKH CCCEEEEECCCCCCC	24.54	22324799
765	Phosphorylation	SYYSLPRSFKHTQRP EEEECCCCCCCCCCC	36.39	27149854
787	Phosphorylation	RHQHLRLSSSSGRLR CCCEEEEECCCCCEE	23.03	22324799
788	Phosphorylation	HQHLRLSSSSGRLRY CCEEEEECCCCCEEE	32.87	27149854
789	Phosphorylation	QHLRLSSSSGRLRYT CEEEEECCCCCEEEE	33.17	22817900
790	Phosphorylation	HLRLSSSSGRLRYTA EEEEECCCCCEEEEE	29.85	22324799
854	Phosphorylation	NSRLARPTRLSLGDP CCCCCCCCCCCCCCC	38.39	21454597
857	Phosphorylation	LARPTRLSLGDPKAS CCCCCCCCCCCCCHH	27.32	26824392
878	Phosphorylation	EQQQQQQSSLHPPEP HHHHHHHHCCCCCCC	30.45	25338131
887	Phosphorylation	LHPPEPKSPGEYVNI CCCCCCCCCCCEEEE	49.18	25521595
891	Phosphorylation	EPKSPGEYVNIEFGS CCCCCCCEEEEECCC	12.52	25619855
898	Phosphorylation	YVNIEFGSGQPGYLA EEEEECCCCCCCEEC	39.31	25619855
903	Phosphorylation	FGSGQPGYLAGPATS CCCCCCCEECCCCCC	10.48	25619855
909	Phosphorylation	GYLAGPATSRSSPSV CEECCCCCCCCCCCC	28.01	25619855
910	Phosphorylation	YLAGPATSRSSPSVR EECCCCCCCCCCCCC	32.07	25619855
932	Phosphorylation	APREETGSEEYMNMD CCCCCCCCHHHCCCC	34.37	25338131
935	Phosphorylation	EETGSEEYMNMDLGP CCCCCHHHCCCCCCC	6.96	22817900
966	Phosphorylation	IGPAPPGSATVCRPT ECCCCCCCCEEECCC	26.92	29514104
970	S-palmitoylation	PPGSATVCRPTRSVP CCCCCEEECCCCCCC	3.61	26165157
983	Phosphorylation	VPNSRGDYMTMQIGC CCCCCCCEEEEEEEC	9.41	22817900
985	Phosphorylation	NSRGDYMTMQIGCPR CCCCCEEEEEEECCC	10.33	28066266
994	Phosphorylation	QIGCPRQSYVDTSPV EEECCCCCCCCCCCC	28.53	18846507
995	Phosphorylation	IGCPRQSYVDTSPVA EECCCCCCCCCCCCC	8.26	25777480
998	Phosphorylation	PRQSYVDTSPVAPVS CCCCCCCCCCCCCCC	25.53	21743459
999	Phosphorylation	RQSYVDTSPVAPVSY CCCCCCCCCCCCCCH	16.95	26824392
1005	Phosphorylation	TSPVAPVSYADMRTG CCCCCCCCHHHHCCC	17.34	25777480
1006	Phosphorylation	SPVAPVSYADMRTGI CCCCCCCHHHHCCCC	13.57	25777480
1074	Phosphorylation	AFTRVNLSPNHNQSA CCEEEECCCCCCCCC	20.60	27087446
1080	Phosphorylation	LSPNHNQSAKVIRAD CCCCCCCCCCEEEEC	35.06	23984901
1096	Phosphorylation	QGCRRRHSSETFSAP CCHHHHCCCCCCCCC	28.23	25521595
1097	Phosphorylation	GCRRRHSSETFSAPT CHHHHCCCCCCCCCC	34.23	25521595
1099	Phosphorylation	RRRHSSETFSAPTRA HHHCCCCCCCCCCCC	25.49	27742792
1101	Phosphorylation	RHSSETFSAPTRAGN HCCCCCCCCCCCCCC	40.53	25619855
1104	Phosphorylation	SETFSAPTRAGNTVP CCCCCCCCCCCCCCC	32.63	25619855
1121	Phosphorylation	AGAAVGGSGGGGGGG CCEECCCCCCCCCCC	28.47	28285833
1129	Phosphorylation	GGGGGGGSEDVKRHS CCCCCCCCHHHHHHC	33.62	28285833
1136	Phosphorylation	SEDVKRHSSASFENV CHHHHHHCCCCCEEE	31.47	26824392
1137	Phosphorylation	EDVKRHSSASFENVW HHHHHHCCCCCEEEE	23.08	26160508
1139	Phosphorylation	VKRHSSASFENVWLR HHHHCCCCCEEEEEC	34.73	25168779
1170	Phosphorylation	AAGGLEKSLNYIDLD CCCCHHHHHHHCCHH	16.69	21743459
1173	Phosphorylation	GLEKSLNYIDLDLAK CHHHHHHHCCHHHHH	10.91	18515860
1204	Phosphorylation	PPHQPLGSNEGNSPR CCCCCCCCCCCCCCC	39.12	26160508
1209	Phosphorylation	LGSNEGNSPRRSSED CCCCCCCCCCCCHHH	30.55	26160508
1213	Phosphorylation	EGNSPRRSSEDLSNY CCCCCCCCHHHHHHH	39.08	21082442
1214	Phosphorylation	GNSPRRSSEDLSNYA CCCCCCCHHHHHHHH	33.06	25521595
1218	Phosphorylation	RRSSEDLSNYASISF CCCHHHHHHHHCEEE	39.87	25619855
1220	Phosphorylation	SSEDLSNYASISFQK CHHHHHHHHCEEECC	9.80	25619855
1222	Phosphorylation	EDLSNYASISFQKQP HHHHHHHCEEECCCC	14.38	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
99	S	Phosphorylation	Kinase	CK2	-	Uniprot
265	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	Uniprot
265	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
302	S	Phosphorylation	Kinase	ROCK1	Q63644	PSP
302	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
302	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	Uniprot
302	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
302	S	Phosphorylation	Kinase	MTOR	P42345	PSP
302	S	Phosphorylation	Kinase	ATPK1	-	GPS
307	S	Phosphorylation	Kinase	JNK1	Q91Y86	PSP
307	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	Uniprot
307	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
307	S	Phosphorylation	Kinase	JNK1	P49185	PSP
307	S	Phosphorylation	Kinase	IKKB	O88351	Uniprot
307	S	Phosphorylation	Kinase	CHUK	Q60680	GPS
307	S	Phosphorylation	Kinase	EIF2AK2	Q03963	GPS
307	S	Phosphorylation	Kinase	PKR	P19525	PSP
318	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
318	S	Phosphorylation	Kinase	PRKCZ	Q02956	GPS
318	S	Phosphorylation	Kinase	PRKCQ	Q04759	GPS
318	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
318	S	Phosphorylation	Kinase	PRKCD	P28867	GPS
318	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
318	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
318	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
325	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
358	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
460	Y	Phosphorylation	Kinase	INSR	P15208	Uniprot
522	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	Uniprot
608	Y	Phosphorylation	Kinase	INSR	P15208	Uniprot
612	S	Phosphorylation	Kinase	GRK2	Q99MK8	PSP
612	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
612	S	Phosphorylation	Kinase	MAPK3	Q63844	GPS
628	Y	Phosphorylation	Kinase	INSR	P15208	Uniprot
632	S	Phosphorylation	Kinase	MTOR	P42345	PSP
632	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
632	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	Uniprot
632	S	Phosphorylation	Kinase	ROCK1	Q63644	PSP
632	S	Phosphorylation	Kinase	ROCK2	P70336	Uniprot
635	S	Phosphorylation	Kinase	ROCK1	Q63644	PSP
635	S	Phosphorylation	Kinase	GRK2	Q99MK8	PSP
635	S	Phosphorylation	Kinase	ROCK2	P70336	PSP
635	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
635	S	Phosphorylation	Kinase	MTOR	P42345	PSP
789	S	Phosphorylation	Kinase	AMPK_GROUP	-	PhosphoELM
789	S	Phosphorylation	Kinase	PRKAA1	P54645	GPS
789	S	Phosphorylation	Kinase	AMPK	-	Uniprot
789	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
789	S	Phosphorylation	Kinase	SIK2	Q8CFH6	Uniprot
891	Y	Phosphorylation	Kinase	INSR	P15208	Uniprot
935	Y	Phosphorylation	Kinase	INSR	P15208	Uniprot
983	Y	Phosphorylation	Kinase	INSR	P15208	Uniprot
1097	S	Phosphorylation	Kinase	PRKCQ	Q02111	GPS
1097	S	Phosphorylation	Kinase	RPS6KB1	P23443	GPS
1173	Y	Phosphorylation	Kinase	INSR	P15208	Uniprot
1220	Y	Phosphorylation	Kinase	INSR	P15208	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Socs1	O35716	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Socs3	O35718	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
265	S	Phosphorylation	25586176
Phosphorylated at Ser-265, Ser-302, Ser-632 and Ser-1097 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1 (By similarity).
302	S	Phosphorylation	25586176
Phosphorylated at Ser-265, Ser-302, Ser-632 and Ser-1097 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1 (By similarity).
307	S	Phosphorylation	25586176
Ser-307 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity).
632	S	Phosphorylation	16098829
Phosphorylated at Ser-265, Ser-302, Ser-632 and Ser-1097 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1 (By similarity).
1097	S	Phosphorylation	17242355
Phosphorylated at Ser-265, Ser-302, Ser-632 and Ser-1097 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1 (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IRS1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC2_MOUSE	Hdac2	physical	15522123
P85A_MOUSE	Pik3r1	physical	12783867
P85A_MOUSE	Pik3r1	physical	14684612
P85A_MOUSE	Pik3r1	physical	15169905
P85A_MOUSE	Pik3r1	physical	16455755
P85A_MOUSE	Pik3r1	physical	15249583
INSR_MOUSE	Insr	physical	15249583
P85A_MOUSE	Pik3r1	physical	15183122
IRS2_MOUSE	Irs2	physical	9729467
RBX1_MOUSE	Rbx1	physical	22033112
PK3CA_MOUSE	Pik3ca	physical	27708159
P85A_MOUSE	Pik3r1	physical	27708159
UBP7_MOUSE	Usp7	physical	27568561
PTEN_MOUSE	Pten	physical	27568561

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IRS1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-324; SER-340;SER-1139 AND SER-1214, AND MASS SPECTROMETRY.	17242355 [Abstract]
"5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 inmouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamideriboside."; Jakobsen S.N., Hardie D.G., Morrice N., Tornqvist H.E.; J. Biol. Chem. 276:46912-46916(2001). Cited for: PHOSPHORYLATION AT SER-789.	11598104 [Abstract]

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