T176B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T176B_MOUSE
• UniProt AC: Q9R1Q6
• Protein Name: Transmembrane protein 176B
• Gene Name: Tmem176b
• Organism: Mus musculus (Mouse).
• Sequence Length: 263
• Subcellular Localization: Nucleus membrane; Multi-pass membrane protein.
• Protein Description: May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells..
• Protein Sequence: MVQSTVTVNGVKVASTHPQSAHISIHIHQKSALEQLLGAVGSLKKFLSWPQARIHYGQLSLGVTQILLGLVSCALGVCLYFGPWTELCAFGCAFWSGSVAILAGVGTIVHEKRQGKLSGQVSCLLLLACIATAAAATVLGVNSLIRQTSVPYYVEIFSTCNPLQSSMDPGYGTVRYSDDSDWKTERCREYLNMMMNLFLAFCIMLTVVCILEIVVSVASLGLSLRSMYGRSSQALNEEESERKLLDGHPAPASPAKEKIPAIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	QLLGAVGSLKKFLSW HHHHHHHHHHHHHCC	30.34	26643407
44	Ubiquitination	LGAVGSLKKFLSWPQ HHHHHHHHHHHCCCH	43.08	22790023
45	Ubiquitination	GAVGSLKKFLSWPQA HHHHHHHHHHCCCHH	57.75	22790023
231	Phosphorylation	LRSMYGRSSQALNEE HHHHHCCCCCCCCHH	23.57	-
240	Phosphorylation	QALNEEESERKLLDG CCCCHHHHHHHHHCC	46.08	-
243	Ubiquitination	NEEESERKLLDGHPA CHHHHHHHHHCCCCC	49.72	22790023
253	Phosphorylation	DGHPAPASPAKEKIP CCCCCCCCCHHHCCC	25.08	25521595
256	Ubiquitination	PAPASPAKEKIPAIL CCCCCCHHHCCCCCC	64.02	22790023
258	Ubiquitination	PASPAKEKIPAIL-- CCCCHHHCCCCCC--	53.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T176B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T176B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T176B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of T176B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-253, AND MASSSPECTROMETRY.
PubMed: 19144319