UNC5B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UNC5B_MOUSE
• UniProt AC: Q8K1S3
• Protein Name: Netrin receptor UNC5B
• Gene Name: Unc5b
• Organism: Mus musculus (Mouse).
• Sequence Length: 945
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Membrane raft . Associated with lipid rafts.
• Protein Description: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. [PubMed: 15510105 Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin]
• Protein Sequence: MRARSGVRSALLLALLLCWDPTPSLAGVDSAGQVLPDSYPSAPAEQLPYFLLEPQDAYIVKNKPVELHCRAFPATQIYFKCNGEWVSQNDHVTQESLDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSSGTTKSRRAYIRIAYLRKNFDQEPLAKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPAQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTVCPVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCVLNQRTLNDPKSHPLETSGDVALYAGLVVAVFVVVAVLMAVGVIVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPNNPQLLHPSAPPDLTASAGIYRGPVYALQDSADKIPMTNSPLLDPLPSLKIKVYNSSTIGSGSGLADGADLLGVLPPGTYPGDFSRDTHFLHLRSASLGSQHLLGLPRDPSSSVSGTFGCLGGRLSLPGTGVSLLVPNGAIPQGKFYDLYLHINKAESTLPLSEGSQTVLSPSVTCGPTGLLLCRPVVLTVPHCAEVIAGDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEAKSCHILLDQLGTYVFMGESYSRSAVKRLQLAIFAPALCTSLEYSLRVYCLEDTPVALKEVLELERTLGGYLVEEPKPLLFKDSYHNLRLSLHDIPHAHWRSKLLAKYQEIPFYHVWNGSQRALHCTFTLERHSLASTEFTCKVCVRQVEGEGQIFQLHTTLAETPAGSLDALCSAPGNAITTQLGPYAFKIPLSIRQKICSSLDAPNSRGNDWRLLAQKLSMDRYLNYFATKASPTGVILDLWEARQQDDGDLNSLASALEEMGKSEMLVAMATDGDC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
222	N-linked_Glycosylation	ARLSDTANYTCVAKN CCCCCCCCCEEEEEE	34.44	-
347	N-linked_Glycosylation	GTLLDSKNCTDGLCV CCEECCCCCCCCEEE	37.56	-
403	S-palmitoylation	VIVYRRNCRDFDTDI HHHHCCCCCCCCCCC	4.13	-
418	O-linked_Glycosylation	TDSSAALTGGFHPVN CCCHHHHHCCCCCCC	30.45	55414533
457	Phosphorylation	GIYRGPVYALQDSAD CCCCCCEEEECCCCC	12.53	22817900
469	Phosphorylation	SADKIPMTNSPLLDP CCCCCCCCCCCCCCC	27.47	28066266
471	Phosphorylation	DKIPMTNSPLLDPLP CCCCCCCCCCCCCCC	14.04	28066266
479	Phosphorylation	PLLDPLPSLKIKVYN CCCCCCCCCEEEEEE	50.40	26824392
487	Phosphorylation	LKIKVYNSSTIGSGS CEEEEEECCCCCCCC	15.92	-
489	Phosphorylation	IKVYNSSTIGSGSGL EEEEECCCCCCCCCC	29.22	-
492	Phosphorylation	YNSSTIGSGSGLADG EECCCCCCCCCCCCC	26.40	-
510	Phosphorylation	LGVLPPGTYPGDFSR EECCCCCCCCCCCCC	32.11	-
511	Phosphorylation	GVLPPGTYPGDFSRD ECCCCCCCCCCCCCC	15.90	-
526	Phosphorylation	THFLHLRSASLGSQH CCEEEEEECCCCCHH	28.68	27087446
528	Phosphorylation	FLHLRSASLGSQHLL EEEEEECCCCCHHHC	34.21	27087446
531	Phosphorylation	LRSASLGSQHLLGLP EEECCCCCHHHCCCC	21.51	27087446
542	Phosphorylation	LGLPRDPSSSVSGTF CCCCCCCCCCCCCCC	39.26	28066266
543	Phosphorylation	GLPRDPSSSVSGTFG CCCCCCCCCCCCCCC	39.90	28066266
544	Phosphorylation	LPRDPSSSVSGTFGC CCCCCCCCCCCCCCC	25.33	28066266
546	Phosphorylation	RDPSSSVSGTFGCLG CCCCCCCCCCCCCCC	33.78	28066266
548	Phosphorylation	PSSSVSGTFGCLGGR CCCCCCCCCCCCCCC	14.89	28066266
581	Phosphorylation	QGKFYDLYLHINKAE CCCEEEEEEEEECCC	8.04	-
868	Phosphorylation	SIRQKICSSLDAPNS HHHHHHHHCCCCCCC	37.09	20495213

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UNC5B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UNC5B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UNC5B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2AAB_MOUSE	Ppp2r1b	physical	21172653
2AAA_MOUSE	Ppp2r1a	physical	21172653
DAPK1_MOUSE	Dapk1	physical	15729359

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.