2AAB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 2AAB_MOUSE
• UniProt AC: Q7TNP2
• Protein Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
• Gene Name: Ppp2r1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 601
• Protein Description: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit..
• Protein Sequence: MAGAAGPGSGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQHFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKTEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDLEALVMPTLRQAAEDKSWRVRYMVADKFSELQKAVGPKIALSDLIPAFQSLLRDCEAEVRAAAAHKVRELCENLPAEGRETVIMNQILPYIKELVSDTNQHVKSALASVIMGLSTVLGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGKEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLALA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGAAGPGS ------CCCCCCCCC	19.14	-
46	Ubiquitination	LRLNSIKKLSTIALA HHHHHHHHHHHHHHH	46.10	-
119	Ubiquitination	EETVVRDKAVESLRQ HHHHHHHHHHHHHHH	43.71	-
128	Phosphorylation	VESLRQISQEHTPVA HHHHHHHCCCCCCCC	22.60	26370283
200	Ubiquitination	VRRAAASKLGEFAKV HHHHHHHHHHHHHHH	56.64	-
284	Ubiquitination	DKFSELQKAVGPKIA HHHHHHHHHHCCCHH	58.63	-
428	Ubiquitination	VELAEDAKWRVRLAI HHHHHHCCHHHHHHH	48.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 2AAB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 2AAB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 2AAB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UNC5B_MOUSE	Unc5b	physical	21172653

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.