| UniProt ID | 2AAA_MOUSE | |
|---|---|---|
| UniProt AC | Q76MZ3 | |
| Protein Name | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | |
| Gene Name | Ppp2r1a | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 589 | |
| Subcellular Localization | Cytoplasm . Chromosome, centromere . Lateral cell membrane . Cell projection, dendrite . Centromeric localization requires the presence of BUB1. | |
| Protein Description | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. [PubMed: 10100624 Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity] | |
| Protein Sequence | MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAADGDDS ------CCCCCCCCC | 16.03 | - | |
| 9 | Phosphorylation | AAADGDDSLYPIAVL CCCCCCCCHHHHHHH | 34.25 | 26824392 | |
| 11 | Phosphorylation | ADGDDSLYPIAVLID CCCCCCHHHHHHHHH | 9.13 | 29233185 | |
| 34 | Ubiquitination | LRLNSIKKLSTIALA HHHHHHHHHHHHHHH | 46.10 | 22790023 | |
| 107 | Ubiquitination | EETVVRDKAVESLRA HHHHHHHHHHHHHHH | 43.71 | 22790023 | |
| 122 | Phosphorylation | ISHEHSPSDLEAHFV HCCCCCHHHHHHHHH | 58.82 | 29899451 | |
| 142 | Phosphorylation | LAGGDWFTSRTSACG HHCCCCCCCCCCCCC | 17.03 | 22006019 | |
| 159 | Phosphorylation | SVCYPRVSSAVKAEL HHHHHHHHHHHHHHH | 17.54 | 24719451 | |
| 163 | Acetylation | PRVSSAVKAELRQYF HHHHHHHHHHHHHHH | 35.54 | 22826441 | |
| 163 | Ubiquitination | PRVSSAVKAELRQYF HHHHHHHHHHHHHHH | 35.54 | 22790023 | |
| 174 | S-nitrosylation | RQYFRNLCSDDTPMV HHHHHHHCCCCCHHH | 4.84 | 21278135 | |
| 174 | S-nitrosocysteine | RQYFRNLCSDDTPMV HHHHHHHCCCCCHHH | 4.84 | - | |
| 188 | Ubiquitination | VRRAAASKLGEFAKV HHHHHHHHHHHHHHH | 56.64 | 22790023 | |
| 194 | Acetylation | SKLGEFAKVLELDNV HHHHHHHHHHCCCCC | 53.31 | 22826441 | |
| 255 | Ubiquitination | LRQAAEDKSWRVRYM HHHHHHCCCHHHHHH | 43.34 | 27667366 | |
| 266 | Ubiquitination | VRYMVADKFTELQKA HHHHHHHHHHHHHHH | 44.44 | 22790023 | |
| 272 | Acetylation | DKFTELQKAVGPEIT HHHHHHHHHHCCCCC | 58.63 | 22826441 | |
| 272 | Ubiquitination | DKFTELQKAVGPEIT HHHHHHHHHHCCCCC | 58.63 | 22790023 | |
| 280 | Ubiquitination | AVGPEITKTDLVPAF HHCCCCCHHHHHHHH | 45.78 | 22790023 | |
| 280 | Acetylation | AVGPEITKTDLVPAF HHCCCCCHHHHHHHH | 45.78 | 23806337 | |
| 307 | Ubiquitination | AAASHKVKEFCENLS HHHHHHHHHHHHHCC | 50.29 | 22790023 | |
| 329 | S-nitrosocysteine | IMTQILPCIKELVSD HHHHHHHHHHHHHHC | 6.60 | - | |
| 329 | S-palmitoylation | IMTQILPCIKELVSD HHHHHHHHHHHHHHC | 6.60 | 28526873 | |
| 329 | S-nitrosylation | IMTQILPCIKELVSD HHHHHHHHHHHHHHC | 6.60 | 20925432 | |
| 374 | Ubiquitination | PLFLAQLKDECPEVR HHHHHHHCCCCCHHH | 39.13 | - | |
| 377 | Glutathionylation | LAQLKDECPEVRLNI HHHHCCCCCHHHHHH | 5.09 | 24333276 | |
| 390 | S-palmitoylation | NIISNLDCVNEVIGI HHHHCCHHHHHHHHH | 3.89 | 28526873 | |
| 390 | S-nitrosylation | NIISNLDCVNEVIGI HHHHCCHHHHHHHHH | 3.89 | 19483679 | |
| 390 | Glutathionylation | NIISNLDCVNEVIGI HHHHCCHHHHHHHHH | 3.89 | 24333276 | |
| 390 | S-nitrosocysteine | NIISNLDCVNEVIGI HHHHCCHHHHHHHHH | 3.89 | - | |
| 416 | Ubiquitination | VELAEDAKWRVRLAI HHHHHHCCHHHHHHH | 48.10 | - | |
| 467 | Ubiquitination | EAATSNLKKLVEKFG HHHHHHHHHHHHHHC | 48.59 | 27667366 | |
| 542 | Ubiquitination | NVRFNVAKSLQKIGP HCHHHHHHHHHHHCC | 47.63 | 27667366 | |
| 546 | Ubiquitination | NVAKSLQKIGPILDN HHHHHHHHHCCCCCC | 55.73 | 22790023 | |
| 554 | Phosphorylation | IGPILDNSTLQSEVK HCCCCCCCCCHHHHH | 30.11 | 29899451 | |
| 555 | Phosphorylation | GPILDNSTLQSEVKP CCCCCCCCCHHHHHH | 34.76 | 20415495 | |
| 561 | Ubiquitination | STLQSEVKPILEKLT CCCHHHHHHHHHHHH | 23.45 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of 2AAA_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of 2AAA_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 2AAA_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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